Results 61 to 70 of about 12,287 (215)
Advanced Science, EarlyView.This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang +11 more
wiley +1 more source
The evolutionary history of mitochondrial porins [PDF]
BMC Evolutionary Biology, 2007 Abstract Background Mitochondrial porins, or voltage-dependent anion-selective channels (VDAC) allow the passage of small molecules across the mitochondrial outer membrane, and are involved in complex interactions regulating organellar and cellular metabolism.
Hausner Georg +3 more
openaire +3 more sources
Advanced NanoBiomed Research, EarlyView.Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi +6 more
wiley +1 more source
The Complexities of Porin Genetic Regulation
Microbial Physiology, 2010 Our understanding of porin regulation has revealed not only increasing complexity in the regulatory mechanisms, but also that the porin repertoire is more extensive than previously conceived. Initially, the OmpR response regulator was described as the master regulator of porin genes, but many more regulators are involved such as CpxR, PhoB, Lrp, Rob ...
Miguel Angel, De la Cruz, Edmundo, Calva
openaire +2 more sources
The Binding of Antibiotics in OmpF Porin [PDF]
Structure, 2013 The structure of OmpF porin in complex with three common antibiotics (zwitterionic ampicillin, anionic ertapenem, and di-anionic carbenicillin) was determined using X-ray crystallography. The three antibiotics are found to bind within the extracellular and periplasmic pore vestibules, away from the narrow OmpF constriction zone.
Ziervogel, Brigitte K., Roux, Benoît
openaire +2 more sources
Molecular dynamics simulations of carbon nanotube porins in lipid bilayers.
Faraday discussions, 2018 Artificial channels made of carbon nanotube (CNT) porins are promising candidates for applications in filtration and molecular delivery devices. Their symmetric shape and high mechanical, chemical, and thermal stability ensure well-defined transport ...
Martin Vögele, J. Köfinger, G. Hummer
semanticscholar +1 more source
Porin fromThiobacillus versutus [PDF]
FEMS Microbiology Letters, 1989 The porin of Thiobacillus versutus IFO 14567 was isolated by extraction of cell-envelopes with sodium dodecyl sulfate. It exhibited strong porin-activity after reconstitution into artificial lipid bilayer membranes. The diameter of the pore was determined as 1.6 nm, with a weak selectivity for cations being observed. The porin migrated as a single band
D, Woitzik +3 more
openaire +2 more sources
Spectroscopic investigation of stability, unfolding and refolding of outer membrane protein porin from Paracoccus denitrificans [PDF]
, 2004 Stability, unfolding and refolding of the outer membrane protein porin from Paracoccus denitrificans was investigated using genetic and spectroscopic methods.
Sukumaran, Suja
core
Angewandte Chemie, EarlyView.Anti‐Glykan‐Antikörper spielen sowohl bei Gesundheit als auch bei Krankheit eine wesentliche Rolle. Der Zugang zu neuartigen Glykanstrukturen ermöglicht Fortschritte bei der Antikörpercharakterisierung für die Entdeckung von Biomarkern, die Antikörperentwicklung und das Impfstoffdesign.
Fabienne Weber +4 more
wiley +1 more source
mBio, 2018 Antibodies acquired after vaccination or natural infection with Gram-negative bacteria, such as invasive Salmonella enterica serovar Typhimurium, can protect against disease.
Anna E. Schager +18 more
semanticscholar +1 more source