Results 81 to 90 of about 28,145 (267)

Molecular Basis of Filtering Carbapenems by Porins from β-Lactam-resistant Clinical Strains of Escherichia coli [PDF]

, 2016
Integral membrane proteins known as porins are the major pathway by which hydrophilic antibiotics cross the outer mem- brane of Gram-negative bacteria. Single point mutations in porins can decrease the permeability of an antibiotic, either by reduction ...
Bajaj, A, Ceccarelli M, Moynie L, Naismith JH, Page MGP, Scorciapino MA, Winterhalter M   +6 more
core   +1 more source

Imipenem Induced Transcriptional Modulation of Multidrug Efflux Pumps and Porin Genes in Carbapenem Resistant Escherichia coli Isolates of Animal Origin [PDF]

, 2022
U. Jaiswal, A. Arun, Ashish Pratap Singh, Soumen Choudhury, Shyama N. Prabhu, Neeraj Kumar Gangwar   +5 more
openalex   +1 more source

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, EarlyView.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

Expression of Genes Associated with Efflux Pump and Porins in Acinetobacter baumannii Isolates Recovered from Different Clinical Specimens

Biomedical and Biotechnology Research Journal
Background: Efflux pumps are crucial bacterial defense mechanisms that reduce antibiotic susceptibility by expelling antibiotics from cells. In Acinetobacter baumannii, this significantly contributes to multidrug resistance.
Alya Amer Rahi, Huda Hadi Al-Hasnawy
doaj   +1 more source

Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food

Veterinary Sciences, 2018
Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial ...
Javier Fernández, Beatriz Guerra, M. Rosario Rodicio   +2 more
doaj   +1 more source

Antibiotic Transport through Porins [PDF]

Biophysical Journal, 2014
The emergence and dissemination of coordinated resistance mechanism (MDR) underline the importance to understand the rate limiting steps in antibiotic action. Here OmpF porin from E. coli is used as an example to demonstrate what limits the penetration of carbapenems.
Bajaj Harsha, CECCARELLI, MATTEO, Mahendran Kozhinjampara Radhakrishnan, James Chloe E., Pages Jean Marie, Winterhalter Mathias   +5 more
openaire   +2 more sources

Phage Therapy as an Alternative Strategy Against Pseudomonas aeruginosa: A Narrative Review of Preclinical and Clinical Evidence

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Phage therapy shows promising efficacy against MDR, XDR, and PDR Pseudomonas aeruginosa infections across different models and administration routes. Evidence highlights reduced mortality, bacterial clearance, and synergy with antibiotics, while emphasizing the need for standardized protocols and advanced delivery systems to support clinical ...
Gustavo Aparecido da Cunha, Raine Piva Amaral, Ana Luisa Cauvila dos Santos, Bárbara Rafaela Ferreira Aio, Maria Fernanda Romboli Durante, Luiz Cosme Cotta Malaquias, Gabriel Magno de Freitas Almeida, Luiz Felipe Leomil Coelho   +7 more
wiley   +1 more source

Reconstruction and modeling protein translocation and compartmentalization in Escherichia coli at the genome-scale [PDF]

, 2014
BackgroundMembranes play a crucial role in cellular functions. Membranes provide a physical barrier, control the trafficking of substances entering and leaving the cell, and are a major determinant of cellular ultra-structure.
Feist, Adam, Lerman, Joshua A., Liu, Joanne K., O’Brien, Edward J., Palsson, Bernhard, Zengler, Karsten   +5 more
core   +3 more sources

Glanders: Past, Present and Future of a Neglected Zoonosis as a Threat in Veterinary and Human Health

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This review displays a comprehensive overview of glanders, including aetiology, epidemiology, pathogenesis, diagnosis, control strategies and ongoing eradication programs. It has also reviewed differential diagnosis and treatment both in animals and humans as well as organism's antimicrobial properties.
Yahya Kanani, Ahmad Oryan, Abdollah Derakhshandeh   +2 more
wiley   +1 more source