Results 91 to 100 of about 1,798,677 (269)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Study on switching from position to stiffness control for musculoskeletal-inspired robot arm based on direct sum decomposition

open access: yesSICE Journal of Control, Measurement, and System Integration
This paper presents a method of switching from position to stiffness control for a two-degree-of-freedom robot arm driven by three pairs of antagonistic actuators by applying the position and stiffness controller with the aim of developing a robot arm ...
Toshimi Shimizu
doaj   +1 more source

FPGA-based embedded system for wind tunnel variable-geometry nozzle positioning [PDF]

open access: yesScientific Technical Review, 2019
Over the last few decades, the accuracy requirements for wind tunnel testing have become much more stringent as aircraft industry strives to achieve the best performance of their products. Investments in advanced capabilities are necessary to obtain more
Ilić Biljana, Milosavljević Mirko
doaj  

Precise Position Control of Holonomic Inchworm Robot Using Four Optical Encoders. [PDF]

open access: yesMicromachines (Basel), 2023
Tanabe K   +9 more
europepmc   +1 more source

Positive control.

open access: yesJournal of Biological Chemistry, 1990
S, Adhya, S, Garges
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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