Results 41 to 50 of about 6,258,452 (248)

A Study of Post-transcriptional m6A Modification. Tang et al.

Here, we develop 4sU-m6A-level and isoform-characterization sequencing (4sU-m6A-LAIC-seq) and 4sU-GLORI, designed to quantify the m6A levels for both newly synthesized and steady-state RNAs at transcript and single-base-resolution levels, respectively ...
Zhou, Y (via Mendeley Data)
core   +2 more sources

ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification

, 2023
Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-angiotensin system, provides protection against several chronic diseases. Besides chronic diseases, ACE2 is the host receptor for SARS-CoV or SARS-CoV-2 virus, mediating the first ...
Tse-Hua Tan, Chia-Wen Wang, Huai-Chia Chuang   +2 more
core   +2 more sources

Genome-wide alternative splicing profile in the posterior kidney of brown trout (Salmo trutta) during proliferative kidney disease

BMC Genomics, 2022
Background The cnidarian myxozoan parasite Tetracapsuloides bryosalmonae causes chronic proliferative kidney disease (PKD) in salmonids. This parasite is a serious threat to wild and cultured salmonids. T.
Arun Sudhagar, Mansour El-Matbouli, Gokhlesh Kumar   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice

Nature Communications, 2021
Post-transcriptional modification of RNA can contribute to regulating behavior. Here, the authors show that modulating the expression of Fto results in epitranscriptomic changes in the mouse hippocampus associated with depression-like behavior.
Shu Liu, Jianbo Xiu, Caiyun Zhu, Kexin Meng, Chen Li, Rongrong Han, Tingfu Du, Lanlan Li, Lingdan Xu, Renjie Liu, Wanwan Zhu, Yan Shen, Qi Xu   +12 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Regulated post-transcriptional RNA cleavage diversifies the eukaryotic transcriptome. [PDF]

, 2010
The complexity of the eukaryotic transcriptome is generated by the interplay of transcription initiation, termination, alternative splicing, and other forms of post-transcriptional modification. It was recently shown that RNA transcripts may also undergo
Bracken, CP, Cameron P. Bracken, Marjan E. Askarian-Amiri, Gregory J. Goodall, Kolle, Gabriel, Korbie, D., Gardiner, B., Gardiner, Brooke B., Grimmond, SM, Marcel E. Dinger, Tim R. Mercer, Mattick, J., Goodall, GJ, Askarian-Amiri, M., Sean M. Grimmond, John S. Mattick, Mercer, TR, Jan M. Szubert, Szubert, J., Dinger, Marcel E., Bracken, C., Brooke B. Gardiner, Korbie, DJ, Kolle, G., Mattick, JS, Szubert, Jan M., Kolle, G, Goodall, Gregory J., Bracken, Cameron P., Askarian-Amiri, Marjan E., Gabriel Kolle, Darren J. Korbie, Goodall, G., Gardiner, BB, Dinger, M., Grimmond, S., Grimmond, Sean M., Mattick, John S., Korbie, Darren J., Dinger, ME, Mercer, Tim R., Szubert, JM, Mercer, T., Askarian-Amiri, ME   +43 more
core   +1 more source

Deciphering the pseudouridine nucleobase modification in human diseases: From molecular mechanisms to clinical perspectives

Clinical and Translational Medicine
RNA pseudouridylation, a dynamic and reversible post‐transcriptional modification found in diverse RNA species, is crucial for various biological processes, including tRNA homeostasis, tRNA transport, translation initiation regulation, pre‐mRNA splicing,
Shiheng Jia, Xue Yu, Na Deng, Chen Zheng, Mingguang Ju, Fanglin Wang, Yixiao Zhang, Ziming Gao, Yanshu Li, Heng Zhou, Kai Li   +10 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis

Cell Reports, 2019
Summary: The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master transcriptional regulator involved in histone H3 lysine 27 trimethylation.
Yi Zeng, Rongfang Qiu, Yang Yang, Tianyang Gao, Yu Zheng, Wei Huang, Jie Gao, Kai Zhang, Ruiqiong Liu, Shuang Wang, Yongqiang Hou, Wenqian Yu, Shuai Leng, Dandan Feng, Wei Liu, Xi Zhang, Yan Wang   +16 more
doaj   +1 more source