The Role of Post-Translational Modifications in Necroptosis [PDF]
BiomoleculesNecroptosis, a distinct form of regulated necrosis implicated in various human pathologies, is orchestrated through sophisticated signaling pathways. During this process, cells undergoing necroptosis exhibit characteristic necrotic morphology and provoke
Hao Xiao +7 more
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Post‐Translational Modifications in Cilia and Ciliopathies [PDF]
Advanced ScienceCilia are microtubule‐based organelles that extend from the surface of most vertebrate cells, and they play important roles in diverse cellular processes during embryonic development and tissue homeostasis.
Jie Ran, Jun Zhou
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Sirtuin Oxidative Post-translational Modifications [PDF]
Frontiers in Physiology, 2021 Increased sirtuin deacylase activity is correlated with increased lifespan and healthspan in eukaryotes. Conversely, decreased sirtuin deacylase activity is correlated with increased susceptibility to aging-related diseases.
Kelsey S. Kalous +2 more
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Post-Translational Modifications of Extracellular Proteasome [PDF]
Molecules, 2020 The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways in eukaryotic cells. Abnormal functioning of this system has been observed in cancer and neurological diseases.
Anna S. Tsimokha +4 more
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HDACs and Their Inhibitors on Post-Translational Modifications: The Regulation of Cardiovascular Disease [PDF]
CellsCardiovascular diseases (CVD), such as myocardial hypertrophy, heart failure, atherosclerosis, and myocardial ischemia/reperfusion (I/R) injury, are among the major threats to human health worldwide. Post-translational modifications alter the function of
Siyi Yang, Yidong Sun, Wei Yu
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Post-translational modifications and bronchopulmonary dysplasia [PDF]
Frontiers in PediatricsBronchopulmonary dysplasia is a prevalent respiratory disorder posing a significant threat to the quality of life in premature infants. Its pathogenesis is intricate, and therapeutic options are limited. Besides genetic coding, protein post-translational
Kun Yang, Ting He, Xue Sun, Wenbin Dong
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Post-translational modifications in heat stress-related diseases [PDF]
Frontiers in Molecular BiosciencesPost-translational modifications (PTMs) act as pivotal molecular hubs integrating heat stress signals into cellular responses driving heat-related diseases like heatstroke.
Qi Cui +5 more
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Implication of protein post translational modifications in gastric cancer [PDF]
Frontiers in Cell and Developmental BiologyGastric cancer (GC) is one of the most common and highly lethal malignant tumors worldwide, and its occurrence and development are regulated by multiple molecular mechanisms.
Houji Song +6 more
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Post-Translational Modifications That Drive Prostate Cancer Progression
Biomolecules, 2021 While a protein primary structure is determined by genetic code, its specific functional form is mostly achieved in a dynamic interplay that includes actions of many enzymes involved in post-translational modifications.
Ivana Samaržija
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Connexins: synthesis, post-translational modifications, and trafficking in health and disease [PDF]
, 2018 Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs.
Aasen, Trond +5 more
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