Post‐Translational Modifications in Cilia and Ciliopathies [PDF]
Advanced ScienceCilia are microtubule‐based organelles that extend from the surface of most vertebrate cells, and they play important roles in diverse cellular processes during embryonic development and tissue homeostasis.
Jie Ran, Jun Zhou
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Histone post-translational modifications of Leishmania braziliensis [PDF]
Scientific DataHistone post-translational modifications (hPTMs) constitute an epigenetic mechanism that plays a fundamental role in the regulation of gene expression in eukaryotic cells. In trypanosomatid parasites, such as Trypanosoma brucei, T.
Rafael Fogaça de Almeida +3 more
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Control of protein stability by post-translational modifications [PDF]
Nature Communications, 2023 Here the authors summarize current knowledge of the regulation of protein stability by various post-translational modifications (PTMs) including methylation and phosphorylation.
Ji Min Lee +3 more
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Post-translational modifications of protein and lung cancer [PDF]
Frontiers in OncologyPost-translational modifications (PTMs) represent a pivotal regulatory mechanism in cellular processes, wherein the addition or removal of specific functional groups to amino acid residues dynamically modulates protein activity, subcellular localization,
Ying Zhao +10 more
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Regulation of the microprocessor by post-translational modifications [PDF]
Frontiers in Cell and Developmental BiologyThe Microprocessor is an essential protein complex that is responsible for the first processing step in the biogenesis of canonical microRNAs. The core of this complex is composed of two proteins, the ribonuclease III enzyme DROSHA and its double ...
Ka Weng Leong +3 more
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Post-translational modifications in heat stress-related diseases [PDF]
Frontiers in Molecular BiosciencesPost-translational modifications (PTMs) act as pivotal molecular hubs integrating heat stress signals into cellular responses driving heat-related diseases like heatstroke.
Qi Cui +4 more
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Mass spectrometry-based profiling of single-cell histone post-translational modifications to dissect chromatin heterogeneity [PDF]
Nature CommunicationsSingle-cell proteomics confidently quantifies cellular heterogeneity, however quantification of post-translational modifications, such as those deposited on histone proteins, remains elusive.
Ronald Cutler +11 more
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HDACs and Their Inhibitors on Post-Translational Modifications: The Regulation of Cardiovascular Disease [PDF]
CellsCardiovascular diseases (CVD), such as myocardial hypertrophy, heart failure, atherosclerosis, and myocardial ischemia/reperfusion (I/R) injury, are among the major threats to human health worldwide. Post-translational modifications alter the function of
Siyi Yang, Yidong Sun, Wei Yu
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Post‐Translational Modifications of TOE3 Regulate Antiviral Defense in Tobacco [PDF]
Advanced SciencePost‐translational modifications (PTMs) affect the function of transcription factors and regulate plant immune responses. APETALA2 (AP2) transcription factor TARGET OF EAT3 (TOE3) plays a pivotal role in plant antiviral immunity. However, little is known
Bolei Jiao +3 more
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The Role of Post-Translational Modifications in Necroptosis [PDF]
BiomoleculesNecroptosis, a distinct form of regulated necrosis implicated in various human pathologies, is orchestrated through sophisticated signaling pathways. During this process, cells undergoing necroptosis exhibit characteristic necrotic morphology and provoke
Hao Xiao +7 more
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