Results 111 to 120 of about 450,881 (322)

Bioprocess Development for Lantibiotic Ruminococcin-A Production in Escherichia coli and Kinetic Insights Into LanM Enzymes Catalysis [PDF]

, 2019
Ruminococcin-A (RumA) is a peptide antibiotic with post-translational modifications including thioether cross-links formed from non-canonical amino acids, called lanthionines, synthesized by a dedicated lanthionine-generating enzyme RumM.
Adrian, Lorenz, Neubauer, Peter, Ongey, Elvis L., Riedel, Sebastian L., Santolin, Lara, Waldburger, Saskia   +5 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Targeting epigenetic and post-translational modifications regulating pyroptosis for the treatment of inflammatory diseases

Pharmacological Research
Inflammatory diseases, including infectious diseases, diabetes-related diseases, arthritis-related diseases, neurological diseases, digestive diseases, and tumor, continue to threaten human health and impose a significant financial burden despite ...
Ri-Wen, Yu-Hang Yang, Tie-Ning Zhang, Chun-Feng Liu, Ni Yang   +4 more
doaj   +1 more source

Roles of Post-translational Modifications in Spinocerebellar Ataxias

Frontiers in Cellular Neuroscience, 2018
Post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, SUMOylation, etc., of proteins can modulate protein properties such as intracellular distribution, activity, stability, aggregation, and interactions ...
Linlin Wan, Keqin Xu, Zhao Chen, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang   +14 more
doaj   +1 more source

Analysis of the extreme diversity of salivary alpha-amylase isoforms generated by physiological proteolysis using liquid chromatography-tandem mass spectrometry [PDF]

, 2012
Saliva is a crucial biofluid for oral health and is also of increasing importance as a non-invasive source of disease biomarkers. Salivary alpha-amylase is an abundant protein in saliva, and changes in amylase expression have been previously associated ...
Baldini, Benjamin L. Schulz, Bruno, Chamindie Punyadeera, Choi, da Costa, Dowling, Dsamou, Fleissig, Gumucio, Hara, Hirtz, Iontcheva, Jamaluddin, Justin J. Cooper-White, Karn, Lamy, Mandel, Merritt, Pfaffe, Punyadeera, Ragunath, Ramachandran, Ramasubbu, Schulz, Siqueira, Topkas, Ulla-Maja Bailey, Wu, Zajacz   +29 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Multiple mechanisms of growth hormone-regulated gene transcription [PDF]

, 2007
Diverse physiological actions of growth hormone (GH) are mediated by changes in gene transcription. Transcription can be regulated at several levels, including post-translational modification of transcription factors, and formation of multiprotein ...
Calinescu, Anda Alexandra, Ceseña, Teresa I., Cui, Tracy Xiao, Huo, Jeffrey S., Iñiguez Lluhí, Jorge A., Kaplani, Julianne, Kwok, Roland, Piwien Pilipuk, Graciela, Schwartz, Jessica   +8 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Fats and function:protein lipid modifications in plant cell signalling [PDF]

, 2017
The post-translational lipid modifications N-myristoylation, prenylation and S-acylation are traditionally associated with increasing protein membrane affinity.
Adjobo-Hermans, Alassimone, Assmann, Batistic, Batistic, Bischoff, Boisson, Bücherl, Couto, de Vries, Dionne Turnbull, Goldberg, Grison, Hemsley, Hemsley, Hemsley, Heo, Kapos, Koh, Konrad, Kumar, Kummel, Lai, Lavy, Li, Liu, Malinsky, Matsui, Meng, Morozova, Nimchuk, Noland, Pierre, Piers A Hemsley, Qi, Qi, Qi, Ranf, Renna, Resh, Running, Running, Ryan, Schiefelbein, Sorek, Sorek, Sorek, Srivastava, Stangl, Takahashi, Thole, Traverso, Zeng, Zhang, Zhou   +54 more
core   +2 more sources