Results 131 to 140 of about 541,798 (360)

Post-translational modifications in mammary gland development and mammary tumor progression [PDF]

, 2015
Breast cancer is one of the most common cancers in women. Estrogen receptor α (ERα) signaling and p53 signaling have important roles in breast cancer progression.
Zhuang, Ting
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases

Frontiers in Neuroscience, 2019
Parkinson’s disease is the second most common neurodegenerative disorder. Although the pathogenesis of Parkinson’s disease is not entirely clear, the aberrant aggregation of α-synuclein has long been considered as an important risk factor.
Jiaming Zhang, Xiaoping Li, Jia-Da Li
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins

International Journal of Molecular Sciences, 2019
Advances in genomics and proteomics have revealed eukaryotic proteomes to be highly abundant in intrinsically disordered proteins that are susceptible to diverse post-translational modifications.
Izzy Owen, F. Shewmaker
semanticscholar   +1 more source

Post-translational modifications and mass spectrometry detection [PDF]

, 2013
In this review, we provide a comprehensive bibliographic overview of the role of mass spectrometry and the recent technical developments in the detection of post-translational modifications (PTMs).
Abbott, Abello, Aebersold, Afjehi-Sadat, Altelaar, Altelaar, Amado, Anderson, Andersson, André M.N. Silva, Annesley, Ball, Bartlett, Beck, Bedair, Beltran, Beltran, Biemann, Bigelow, Blom, Bodenmiller, Bodnar, Boersema, Bollineni, Brandes, Bravo, Bridgewater, Buhrman, Carbone, Carbone, Cech, Chauhan, Choudhary, Consortium, Corinne M. Spickett, Couto, Cox, Cutillas, Dai, Dalle-Donne, Danielsen, Deng, Dephoure, Domingues, Domon, Doonan, Drake, Dreisewerd, Drogaris, Edwards, El-Aneed, Eng, Engholm-Keller, Engholm-Keller, Evans, Fenaille, Fenaille, Ferrando, Ferreira, Fields, Fila, Finch, Fonseca, Forbes, Forman, Frese, Frese, Fridriksson, Gan, García-Santamarina, Garrels, Gaskell, Gates, Ge, Gevaert, Giorgianni, Giulivi, Good, Gould, Gronborg, Grune, Grune, Guan, Guedes, Guedes, Gueraud, Gupta, Gupta, Guthals, Hardman, Hawkins, Hebert, Henzel, Hjerrild, Hunt, Ikonomou, Inoue, Isom, Jaffrey, James, Jennings, Jensen, Jensen, Jessome, Julenius, Karas, Kato, Kebarle, Kelleher, Kelleher, Khoury, Kim, Kim, Klose, Knochenmuss, Kolarich, Konopka, Krause, Kullolli, Kumar, Kurahashi, Kuzyk, Lai, Lebedev, Lee, Leichert, Leonard, Leonard, Lin, Little, Liu, Liu, Loo, M.Rosário M. Domingues, Macek, Macek, Madera, Madian, Madian, Madian, Mann, Mann, McAlister, McLafferty, McLafferty, Melo-Braga, Mendez, Merrick, Messana, Meucci, Meyer, Michalski, Mirgorodskaya, Mirzaei, Molina, Monzo, Morand, Mouls, Nahnsen, Narasimhan, Nelson, Nemeth-Cawley, Nemeth-Cawley, Niu, Niwa, O'Donovan, O'Farrell, Olsen, Olsen, Ong, Ongay, Palmisano, Patterson, Pedro Domingues, Peng, Perdivara, Perkins, Perkins, Petersen, Pichler, Pierce, Plewczynski, Potgieter, Rabilloud, Ramachandran, Rauniyar, Reinders, Reis, Renauer, Rietschel, Roe, Rosenqvist, Rui Vitorino, Ryan, Sadineni, Sano, Saurin, Sayre, Scheele, Schey, Schilling, Shacter, Sharp, Shelton, Shetty, Shi, Shilov, Shirran, Shringarpure, Sibbald, Sigrist, Silva, Silva, Smith, Spicket, Spickett, Spickett, Spickett, Stadtman, Stapels, Summerfield, Syka, Sylvestersen, Takanishi, Tan, Tanaka, Tang, Thakur, Thamsen, Thelen, Thingholm, Thompson, Tian, Tinette, Todorovski, Tran, Van Damme, Vandenbogaert, Vitorino, Vosseller, Wagner, Wang, Washburn, Wiesner, Wilkins, Winterbourn, Witze, Wuhrer, Xia, Xu, Xu, Xu, Xue, Yamashita, Yang, Yates, Yates, Yates, Young, Yount, Zhang, Zhang, Zhao, Zhou, Zhu, Zubarev, Zubarev   +266 more
core   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Lysine post-translational modifications of collagen

Essays in Biochemistry, 2012
Type I collagen is the most abundant structural protein in vertebrates. It is a heterotrimeric molecule composed of two α1 chains and one α2 chain, forming a long uninterrupted triple helical structure with short non-triple helical telopeptides at both the N- and C-termini.
Mitsuo Yamauchi, Marnisa Sricholpech
openaire   +3 more sources

Friend or foe—Post-translational modifications as regulators of phase separation and RNP granule dynamics

Journal of Biological Chemistry, 2018
Ribonucleoprotein (RNP) granules are membrane-less organelles consisting of RNA-binding proteins (RBPs) and RNA. RNA granules form through liquid–liquid phase separation (LLPS), whereby weak promiscuous interactions among RBPs and/or RNAs create a dense ...
Mario Hofweber, D. Dormann
semanticscholar   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source