Results 141 to 150 of about 541,798 (360)
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Foxp3 Post-translational Modifications and Treg Suppressive Activity
Frontiers in Immunology, 2019 Regulatory T cells (Tregs) are engaged in maintaining immune homeostasis and preventing autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which can suppress the immune response via multiple distinct mechanisms.
Guoping Deng +6 more
doaj +1 more source
Motifs tree: a new method for predicting post-translational modifications [PDF]
, 2017 Motivation: Post-translational modifications (PTMs) are important steps in the maturation of proteins. Several models exist to predict specific PTMs, from manually detected patterns to machine learning methods.
Charpilloz, Christophe +3 more
core
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Pathological implication of protein post-translational modifications in cancer.
Molecular Aspects of Medicine, 2022 Sheng Pan, Ru Chen
semanticscholar +1 more source
Post-translational modifications and p21ras function [PDF]
, 1994 The ras gene family consists of three members that encode highly similar proteins of 21Kd (p21ras/Ras). This protein is plasma membrane associated, binds guanine nucleotides and has intrinsic GTPase activity.
Cadwallader, Karen Anne
core
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
T cells specific for post-translational modifications escape intrathymic tolerance induction
Nature Communications, 2018 Post-translational modifications are associated with autoimmune diseases but definitive evidence of their contribution to escape from central tolerance mechanisms is needed.
Bruno Raposo +11 more
doaj +1 more source