Results 11 to 20 of about 447,325 (322)

Post-translational modifications of exosomal proteins

Frontiers in Immunology, 2014
Exosomes mediate intercellular communication and participate in many cell processes such as cancer progression, immune activation or evasion, and the spread of infection.
Olga eMoreno-Gonzalo, Carolina eVillaroya-Beltri, Francisco eSánchez-Madrid   +2 more
doaj   +6 more sources

Post-Translational Modifications and Diabetes

Biomolecules
Diabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for type 2 diabetes (T2D).
Chiranjeev Sharma, Abu Hamza, Emily Boyle, Dickson Donu, Yana Cen   +4 more
doaj   +3 more sources

Post-translational modifications in neurodegeneration

AIMS Biophysics, 2015
Post-translational modifications increase proteome functionality for managing all aspects of normal cell biology. They are based on the covalent attachment of functional groups, leading to phosphorylation, acetylation, glycosylation, acylation ...
Federico Benetti, Alessandro Didonna
doaj   +3 more sources

Post-translational Modifications of the Protein Termini [PDF]

Frontiers in Cell and Developmental Biology, 2021
Post-translational modifications (PTM) involve enzyme-mediated covalent addition of functional groups to proteins during or after synthesis. These modifications greatly increase biological complexity and are responsible for orders of magnitude change ...
Li Chen, Anna Kashina
doaj   +4 more sources

Post-Translational Modifications of TRP Channels [PDF]

Cells, 2014
Transient receptor potential (TRP) channels constitute an ancient family of cation channels that have been found in many eukaryotic organisms from yeast to human.
Olaf Voolstra, Armin Huber
doaj   +4 more sources

Post-translational modifications and their implications in cancer

Frontiers in Oncology, 2023
Post-translational modifications (PTMs) are crucial regulatory mechanisms that alter the properties of a protein by covalently attaching a modified chemical group to some of its amino acid residues. PTMs modulate essential physiological processes such as
Hashnu Dutta, Hashnu Dutta, Nishant Jain, Nishant Jain   +3 more
doaj   +3 more sources

Post-translational modifications in prion diseases

Frontiers in Molecular Neuroscience
More than 650 reversible and irreversible post-translational modifications (PTMs) of proteins have been listed so far. Canonical PTMs of proteins consist of the covalent addition of functional or chemical groups on target backbone amino-acids or the ...
Chloé Bizingre, Chloé Bizingre, Clara Bianchi, Clara Bianchi, Anne Baudry, Anne Baudry, Aurélie Alleaume-Butaux, Aurélie Alleaume-Butaux, Benoit Schneider, Benoit Schneider, Benoit Schneider, Mathéa Pietri, Mathéa Pietri   +12 more
doaj   +5 more sources

Post-translational modifications of EZH2 in cancer [PDF]

Cell & Bioscience, 2020
Enhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 upregulation results in cancer development and poor prognosis of cancer patients.
Zhongwei Li, Minle Li, Diandian Wang, Pingfu Hou, Xintian Chen, Sufang Chu, Dafei Chai, Junnian Zheng, Jin Bai   +8 more
doaj   +4 more sources

Post-translational modifications on the retinoblastoma protein

Journal of Biomedical Science, 2022
The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour suppression. It is frequently inactivated in various tumours.
Linbin Zhou, Danny Siu-Chun Ng, Jason C. Yam, Li Jia Chen, Clement C. Tham, Chi Pui Pang, Wai Kit Chu   +6 more
doaj   +3 more sources

Editorial: Bacterial Post-translational Modifications

Frontiers in Microbiology, 2022
International ...
Valerie J. Carabetta, Julie Hardouin, Julie Hardouin   +2 more
doaj   +5 more sources