Results 21 to 30 of about 256,188 (239)
Post-translational modifications of exosomal proteins
Frontiers in Immunology, 2014 Exosomes mediate intercellular communication and participate in many cell processes such as cancer progression, immune activation or evasion, and the spread of infection.
Olga eMoreno-Gonzalo +2 more
doaj +1 more source
Post-translational modifications on the retinoblastoma protein
Journal of Biomedical Science, 2022 The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour suppression. It is frequently inactivated in various tumours.
Linbin Zhou +6 more
doaj +1 more source
Potential protein post-translational modification in ERp57: A phenotype marker for male fertility
Journal of Human Reproductive Sciences, 2010 Background : In protein expression, post-translational modification is an important process. It is also an important process in human reproductive science. ERp57 is a molecule that is mentioned for post-translational modification. ERp57 is a component of
Viroj Wiwanitkit
doaj +1 more source
Post-Translational Modifications and Diabetes
BiomoleculesDiabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for type 2 diabetes (T2D).
Chiranjeev Sharma +4 more
doaj +1 more source
Post-translational modifications of EZH2 in cancer
Cell & Bioscience, 2020 Enhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 upregulation results in cancer development and poor prognosis of cancer patients.
Zhongwei Li +8 more
doaj +1 more source
Regulation of Lignin Biosynthesis by Post-translational Protein Modifications
Frontiers in Plant Science, 2020 Post-translational modification of proteins exerts essential roles in many biological processes in plants. The function of these chemical modifications has been extensively characterized in many physiological processes, but how these modifications ...
Daniel B. Sulis, Jack P. Wang
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Post-translational modifications and their implications in cancer
Frontiers in Oncology, 2023 Post-translational modifications (PTMs) are crucial regulatory mechanisms that alter the properties of a protein by covalently attaching a modified chemical group to some of its amino acid residues. PTMs modulate essential physiological processes such as
Hashnu Dutta +3 more
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A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Nature Communications, 2020 The mechanisms by which deubiquitinases modulate tumour progression are not fully understood. Here, the authors perform an RNAi screen and identify that the deubiquitinase OTUD5 suppresses cancer growth in a TRIM25 dependent manner, which in turn ...
Fangzhou Li +15 more
doaj +1 more source