Results 21 to 30 of about 541,748 (328)
Cell Death and Disease, 2021 Neurodegenerative diseases, a subset of age-driven diseases, have been known to exhibit increased oxidative stress. The resultant increase in reactive oxygen species (ROS) has long been viewed as a detrimental byproduct of many cellular processes ...
Y. Lee, Weifeng He, Y. Liou
semanticscholar +1 more source
Connexins: synthesis, post-translational modifications, and trafficking in health and disease [PDF]
, 2018 Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs.
Aasen, Trond +5 more
core +7 more sources
Post-Translational Modifications Aid Archaeal Survival
Biomolecules, 2020 Since the pioneering work of Carl Woese, Archaea have fascinated biologists of almost all areas given their unique evolutionary status, wide distribution, high diversity, and ability to grow in special environments.
Ping Gong +4 more
doaj +1 more source
Phosphorylation of Kindlins and the Control of Integrin Function
Cells, 2021 Integrins serve as conduits for the transmission of information between cells and their extracellular environment. Signaling across integrins is bidirectional, transducing both inside-out and outside-signaling.
Katarzyna Bialkowska +2 more
doaj +1 more source
Role of Histone Post-Translational Modifications in Inflammatory Diseases
Frontiers in Immunology, 2022 Inflammation is a defensive reaction for external stimuli to the human body and generally accompanied by immune responses, which is associated with multiple diseases such as atherosclerosis, type 2 diabetes, Alzheimer’s disease, psoriasis, asthma ...
Yingying Lin +7 more
semanticscholar +1 more source
Post-Translational Modifications of Extracellular Proteasome
Molecules, 2020 The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways in eukaryotic cells. Abnormal functioning of this system has been observed in cancer and neurological diseases.
Anna S. Tsimokha +4 more
doaj +1 more source
Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]
, 2012 Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone +2 more
core +2 more sources
Protein modification and maintenance systems as biomarkers of ageing [PDF]
, 2015 Changes in the abundance and post-translational modification of proteins and accumulation of some covalently modified proteins have been proposed to represent hallmarks of biological ageing.
Friguet, Bertrand +7 more
core +3 more sources
Post-Translational Modifications Control Phase Transitions of Tau [PDF]
ACS Central ScienceWyatt C. Powell +10 more
doaj +2 more sources
An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]
, 2015 Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro +1 more
core +1 more source