Results 201 to 210 of about 76,851 (293)

Integrated analysis to study the interplay between post-translational modifications (PTM) in hepatitis C virus proteins and hepatocellular carcinoma (HCC) development [PDF]

, 2022
Aqsa Ikram, Bisma Rauff, Badr Alzahrani, Faryal Mehwish Awan, Ayesha Obaid, Anam Naz, Salik Javed Kakar, Hussnain Ahmed Janjua   +7 more
openalex   +1 more source

The Flagellin‐Specific Chaperone FliS of Borrelia burgdorferi Controls the Cytoplasmic Pool of Flagellins at the Level of Translation Initiation, Secretion, and Proteolysis

Molecular Microbiology, EarlyView.
FliS, a flagellin protein chaperon of the Lyme disease pathogen Borrelia burgdorferi, controls the cytoplasmic pool of flagellins (FlaB) at the level of translation initiation, secretion, and proteolysis. Deletion of fliS blocks FlaB secretion and translation initiation through a pattern‐switching mechanism of FliS‐FlaB‐FliW/CsrA. Therefore, the mutant
Ching Wooen Sze, Kai Zhang, Michael J. Lynch, Wangbiao Guo, Jun Liu, Brian R. Crane, Chunhao Li   +6 more
wiley   +1 more source

B4 Raf‐like MAPKKK RAF24 regulates Arabidopsis thaliana flowering time through HISTONE MONO‐UBIQUITINATION 2

New Phytologist, EarlyView.
Summary The timing of flowering is a critical agronomic trait governed by an extensive and sophisticated regulatory network. To date, limited understanding of how posttranslational modifications regulate flowering time exists. Here, using Arabidopsis, we resolve a role for the B4 Raf‐like MAPKKK protein kinase RAF24 in regulating flowering time.
Qiaomu Li, Le Wang, Lauren E. Grubb, Mohana Talasila, Maria Camila Rodriguez Gallo, Devang Mehta, Sabine Scandola, Richard Glen Uhrig   +7 more
wiley   +1 more source

Systematic analysis of the effects of splicing on the diversity of post-translational modifications in protein isoforms using PTM-POSE

AbstractPost-translational modifications (PTMs) and splicing are important regulatory processes for controlling protein function and activity. Despite examples of interplay between alternative splicing and cell signaling in literature, there have been few detailed analyses of the impacts of alternative splicing on PTMs, partly due to difficulties in ...
Sam Crowl, Maeve Bella Coleman, Andrew Chaphiv, Ben T. Jordan, Kristen M. Naegle   +4 more
openaire   +1 more source

Mass spectrometry reveals age‐dependent collagen decline in murine atria

Annals of the New York Academy of Sciences, EarlyView.
Using mass spectrometry, we analyzed the atrial ECM of young (12 weeks) and old (77 weeks) C57BL/6J mice. Results showed a marked decrease in collagen content with age, alongside increases in specific ECM‐related proteins (e.g., MMP9, S100A9, VWA3A).
Nathalie Ringström, Charlotte Edling, Giovanna Nalesso, Javier Barallobre‐Barreiro, Kamalan Jeevaratnam   +4 more
wiley   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

ERF.D2 negatively controls drought tolerance through synergistic regulation of abscisic acid and jasmonic acid in tomato

Plant Biotechnology Journal, EarlyView.
Summary Plants inevitably encounter a diverse array of constantly changing environmental stresses, and drought stands out as one of the most severe threats to plants. Abscisic acid (ABA) and jasmonic acid (JA) work synergistically to increase plant drought tolerance, but their interplay during drought response remains elusive.
Changan Zhu, Xinyan Li, Min Zhang, Shuwen Wang, Beiyu Jing, Chaoyi Hu, Hannah Rae Thomas, Yanhong Zhou, Jingquan Yu, Zhangjian Hu   +9 more
wiley   +1 more source

Targeting epigenetic and post-translational modifications regulating pyroptosis for the treatment of inflammatory diseases

Pharmacological Research
Inflammatory diseases, including infectious diseases, diabetes-related diseases, arthritis-related diseases, neurological diseases, digestive diseases, and tumor, continue to threaten human health and impose a significant financial burden despite ...
Ri-Wen, Yu-Hang Yang, Tie-Ning Zhang, Chun-Feng Liu, Ni Yang   +4 more
doaj  

The SCARECROW‐LIKE transcription factor from Populus davidiana × P. bolleana simultaneously improved drought tolerance and plant growth through acetylation‐dependent mechanisms

Plant Biotechnology Journal, EarlyView.
Summary The GAI‐RGA‐and‐SCR (GRAS) family of plant‐specific transcription factors (TFs) is essential for development and stress tolerance, but their role in drought resistance and growth remains unclear. Here, we characterized the SCARECROW‐LIKE (SCL) TF PdbSCL1 from Populus davidiana × P.
Pengyu Wang, Xue Yang, Shilin Sun, Jingxin Wang, Jingwen Wang, Xiaofu Li, Dandan Li, Yucheng Wang   +7 more
wiley   +1 more source

Chronic and acute mediators of passive viscoelasticity in human skeletal muscle fibres

Experimental Physiology, EarlyView.
Abstract The cellular viscoelastic modulus in skeletal muscle tissue responds dynamically to chronic stressors, such as age and exercise. Passive tissue mechanics can also be sensitive to acute stimuli, such as mechanical loading and/or activation‐induced muscle fatigue.
Grace E. Privett, Austin W. Ricci, Karen Wiedenfeld Needham, Damien M. Callahan   +3 more
wiley   +1 more source