Results 211 to 220 of about 85,477 (330)

Towards an Analytical Procedure Control Strategy for the Capillary Zone Electrophoresis Method for Monoclonal Antibodies: Alternatives for ε‐Aminocaproic Acid and Triethylenetetramine

ELECTROPHORESIS, EarlyView.
ABSTRACT The ICH guideline Q14 on analytical procedure development underlines the importance of science and risk‐based methods for the evaluation of the quality of medicines. Ultimately, a pharmaceutical company, the sponsor, is responsible that the analytical method is fit‐for‐purpose during routine use throughout its lifecycle. Part of the analytical
Joanne Baxter, Lori Fitton, Cari E. Sänger ‐ van de Griend   +2 more
wiley   +1 more source

PubMed-Scale Event Extraction for Post-Translational Modifications, Epigenetics and Protein Structural Relations [PDF]

, 2012
Ananiadou, S, Björne, J, Ginter, F, Ohta, T, Pyysalo, S, Salakoski, T, Van de Peer, Y, Van Landeghem, S   +7 more
core  

Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis

Exploration, EarlyView.
NaCr promotes KCr to impede the inflammatory progression of ulcerative colitis. KCr induces mitophagy by activating the PINK1/PARKIN pathway to restrict NLRP3 inflammasome activation, thereby decreasing the production and release of various inflammatory cytokines, such as IL‐1β and TNF‐α. KCr induces mitophagy and inhibits NLRP3 inflammasome activation
Tongtong Liu, Binyan Lin, Ying Zhang, Jiayu Su, Xiaochao Hu, Xuan Wang, E‐Hu Liu, Shijia Liu   +7 more
wiley   +1 more source

Metabolite‐Guided Acetylation Therapy: Astragaloside IV Reverses Diabetic Nephropathy via Gna13‐Driven Purine Metabolic Reprogramming

Food Frontiers, EarlyView.
This study unveils how ASIV reverses diabetic nephropathy by restoring Gna13‐K363 acetylation and reprogramming purine metabolism. Using spatial metabolomics and acetylproteomics, we identified zonation‐specific purine dysregulation in diabetic kidneys, with ASIV normalizing metabolite distribution (hypoxanthine, cAMP, guanine) and targeting Gna13 ...
Shi Qiu, Sifan Guo, Dandan Xie, Zhibo Wang, Ying Cai, Xian Wang, Qiang Yang, Chunsheng Lin, Hong Yao, Qiqi Zhao, Yu Guan, Songqi Tang, Yiqiang Xie, Aihua Zhang   +13 more
wiley   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, EarlyView.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, EarlyView.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source

Large Scale Purification and Characterization of A21 Deamidated Variant-Most Prominent Post Translational Modification (PTM) for Insulins Which Is Widely Observed in Insulins Pharmaceutical Manufacturing [PDF]

, 2020
Vibhava Shukla, Koduru Sriva, Madhu Kumar M S, Navratna Vajpai, Neha Agarwal, S. Nethra, Baggavalli P Somesh, Abhishek Kulshrestha, Partha Hazra   +8 more
openalex   +1 more source

Human Breast Milk‐Derived Exosomal FP671120.4 Inhibits Macrophage M1 Polarization via Modulating the ELAVL1/Nrf2 Axis in Sepsis‐Associated Liver Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐associated liver injury (SALI) plays a major role in aggravating disease progression and worsening prognosis in patients with sepsis. Macrophage polarization is a key factor in the modulation of SALI progression. Recent studies have shown that human breast milk‐derived exosomes (HBM‐Exos) regulate processes involved in macrophage ...
Zhao‐Bin Yang, Yi‐Bin Gao, Xiao‐Mei Cheng, Lu‐Zhen Qiu   +3 more
wiley   +1 more source