Results 211 to 220 of about 41,962 (282)

The multifaceted role of post-translational modifications in macrophage polarization: from mechanisms to therapeutic targets. [PDF]

Front Immunol
Guo R, Qi F.
europepmc   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

The role and mechanism of post-translational modifications (PTMs) in immune-related eye diseases

Yanru Wang, Xianyang Liu, Shuhao Zeng, Wenxian Yang, Fan Cao, Shengping Hou   +5 more
openalex   +1 more source

Systematic analysis of the effects of splicing on the diversity of post-translational modifications in protein isoforms using PTM-POSE [PDF]

Sam Crowl, Maeve Bella Coleman, Andrew Chaphiv, Ben T. Jordan, Kristen M. Naegle   +4 more
openalex   +1 more source

Large language models for bioinformatics

Quantitative Biology, Volume 14, Issue 1, March 2026.
Abstract With the rapid advancements in large language model technology and the emergence of bioinformatics‐specific language models (BioLMs), there is a growing need for a comprehensive analysis of the current landscape, computational characteristics, and diverse applications.
Wei Ruan, Yanjun Lyu, Jing Zhang, Jiazhang Cai, Peng Shu, Yang Ge, Yao Lu, Shang Gao, Yue Wang, Peilong Wang, Lin Zhao, Tao Wang, Yufang Liu, Luyang Fang, Ziyu Liu, Zhengliang Liu, Yiwei Li, Zihao Wu, Junhao Chen, Hanqi Jiang, Yi Pan, Zhenyuan Yang, Jingyuan Chen, Shizhe Liang, Wei Zhang, Terry Ma, Yuan Dou, Jianli Zhang, Xinyu Gong, Qi Gan, Yusong Zou, Zebang Chen, Yuanxin Qian, Shuo Yu, Jin Lu, Kenan Song, Xianqiao Wang, Andrea Sikora, Gang Li, Xiang Li, Quanzheng Li, Yingfeng Wang, Lu Zhang, Yohannes Abate, Lifang He, Wenxuan Zhong, Rongjie Liu, Chao Huang, Wei Liu, Ye Shen, Ping Ma, Hongtu Zhu, Yajun Yan, Dajiang Zhu, Tianming Liu   +54 more
wiley   +1 more source

Deep learning model of post-translational modification regulating liquid-liquid phase separation. [PDF]

Commun Chem
Hong X, Lv J, Li Z, Zhu J, Li J, Rahman MU, Wei T, Mu J, Chen HF.   +8 more
europepmc   +1 more source

Elucidation of Proteoforms of Chinese Hamster Ovary (CHO) Phospholipase B‐Like 2 (PLBL2) Captured From a Monoclonal Antibody

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 406-419, February 2026.
A platform approach to the affinity capture and enrichment of host cell proteins to enable their subsequent deep characterization and elucidation of variants or proteoforms (e.g., molecular size variants, charge variants, glycoforms, etc.). ABSTRACT Removing host cell proteins (HCPs) during biotherapeutic manufacturing is essential to ensure patient ...
Michael E. Dolan, Lei (Leo) Wang, Alexander Tedeschi, Yan Wang, Christopher Barton, Sheldon F. Oppenheim, Zhaohui Sunny Zhou   +6 more
wiley   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source

Intact Proteoform Analysis by Capillary Electrophoresis–Mass Spectrometry. Are We There Yet?

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Mass spectrometry (MS) and top–down proteomics (TDP) have emerged as powerful tools to decipher proteoform‐level information, advancing biological insight and translational research. This study unites leaders in capillary electrophoresis (CE) and MS from multiple institutions across the globe to showcase the reproducibility, unique information, and ...
Noah Gould, Qianjie Wang, Jeffrey N. Agar, Jennifer S. Brodbelt, Daoyang Chen, Kellye A. Cupp‐Sutton, Elena Domínguez‐Vega, Fei Fang, Marianne Fillet, Matthew S Fischer, Attila Gaspar, Ying Ge, Marie‐Jia Gou, Michal Greguš, Christoph Gstöttner, Narmin Hamidli, Amanda Helms, Md Amin Hossain, Kyle J. Juetten, Neil L. Kelleher, Tobias Kraus, Eli J. Larson, J. Scott Mellors, Cynthia Nagy, Christian Neusüß, Erin A. Redman, Jasmin Schairer, Si Wu, Tian Xu, Zhitao Zhao, Guijie Zhu, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +33 more
wiley   +2 more sources

Missense3D-PTMdb an interactive web resource to explore and visualize genetic variants and post-translational modifications sites (PTMs) using AlphaFold 3D models [PDF]

Haotian Zhao, Ryan Pye, Grace Walker, Wendy Tran, Olivia Simmonds, Ifigenia Tsitsa, Suhail A. Islam, Gordon Hanna, Alessia David   +8 more
openalex   +1 more source