Results 211 to 220 of about 76,851 (293)
Large Scale Purification and Characterization of A21 Deamidated Variant-Most Prominent Post Translational Modification (PTM) for Insulins Which Is Widely Observed in Insulins Pharmaceutical Manufacturing [PDF]
, 2020 Vibhava Shukla +8 more
openalex +1 more source
Revolutionizing multi‐omics analysis with artificial intelligence and data processing
Quantitative Biology, Volume 13, Issue 3, September 2025.Abstract Our understanding of intricate biological systems has been completely transformed by the development of multi‐omics approaches, which entail the simultaneous study of several different molecular data types. However, there are many obstacles to overcome when analyzing multi‐omics data, including the requirement for sophisticated data processing
Ali Yetgin
wiley +1 more source
A Method for Constructing Nucleosome Arrays with Spatially Defined Histone PTMs and DNA Damage
Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.This work advances methodology by addressing challenges in mimicking the complex in vivo spatial relationships of histone acetylation and DNA damage. The combination of an abiotic/enzymatic hybrid catalyst system (ABEHCS) and the plug‐and‐play method has constituted a versatile platform to construct nucleosome arrays with precise histone acetylation ...
Ziyun Liu +6 more
wiley +2 more sources
, 2020 Matrix metalloproteinases (MMPs) are a family of extracellular endopeptidases, functionally implicated in regulating physiological and pathological processes. Subsequently, MMPs are regulated by transcriptional and post-transcriptional control of their gene expression, zymogen activation, and extracellular inhibition.
openaire +1 more source
Mass Spectrometry Reviews, Volume 44, Issue 4, Page 599-629, July/August 2025.Abstract Immunopeptidomics is becoming an increasingly important field of study. The capability to identify immunopeptides with pivotal roles in the human immune system is essential to shift the current curative medicine towards personalized medicine. Throughout the years, the field has matured, giving insight into the current pitfalls. Nowadays, it is
Daniel Flender +5 more
wiley +1 more source
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
Plant, Cell &Environment, Volume 48, Issue 7, Page 5498-5513, July 2025.ABSTRACT The ubiquitin‐proteasome pathway modulates protein stability, which impacts plant responses to abiotic stresses, such as drought. Our previous study reported that the pepper GRAS‐type transcription factor CaGRAS1 plays a positive role in drought resistance.
Woonhee Baek +3 more
wiley +1 more source
MicroRNA‐100‐5p Exacerbates Myocardial Ischemia–Reperfusion Injury Through Downregulation of PRMT5
The FASEB Journal, Volume 39, Issue 11, 15 June 2025.MiR‐100‐5p overexpression downregulates PRMT5, leading to increased PTEN activity and reduced AKT signaling. This molecular cascade promotes cardiomyocyte apoptosis, enhances fibrotic remodeling, and exacerbates cardiac dysfunction following myocardial ischemia–reperfusion injury.
Zhenya Wang +9 more
wiley +1 more source
PubMed-Scale Event Extraction for Post-Translational Modifications, Epigenetics and Protein Structural Relations [PDF]
, 2012 Ananiadou, S +7 more
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