Results 231 to 240 of about 76,851 (293)

Post-Translational Modifications in Multiple Myeloma: Mechanisms of Drug Resistance and Therapeutic Opportunities. [PDF]

Biomolecules
Hu S, Xu J, Cui W, Jin H, Wang X, Maimaitiyiming Y.   +5 more
europepmc   +1 more source

High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study finds that KAT2A mediates the lactylation modification of the non‐histone protein RCC2 at K124, facilitating the recruitment of free SERBP1 and aiding in the formation of the initial SERBP1‐MAD2L1 complex. SERBP1 enhances the stability of MAD2L1 mRNA and promotes cellular proliferation.
Bowen Zheng, Yunhao Pan, Fengyuan Qian, Diya Liu, Danrong Ye, Bolin Yu, Seng Zhong, Wenfang Zheng, Xuehui Wang, Baian Zhou, Yuying Wang, Lin Fang   +11 more
wiley   +1 more source

α-Synuclein Pathology in Synucleinopathies: Mechanisms, Biomarkers, and Therapeutic Challenges. [PDF]

Int J Mol Sci
Arias-Carrión O, Guerra-Crespo M, Padilla-Godínez FJ, Soto-Rojas LO, Manjarrez E.   +4 more
europepmc   +1 more source

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun, Yangyang Shi, Chen Yan, Shunmin Wang, Linhui Han, Fudong Li, Ximing Xu, Yuan Wang, Jingchuan Sun, Zijian Kang, Jiangang Shi   +10 more
wiley   +1 more source

Proteomic Analysis of Marine Bacteriophages: Structural Conservation, Post-Translational Modifications, and Phage-Host Interactions. [PDF]

Environ Microbiol
Wei S, Wang A, Cai L, Ma R, Lu L, Li J, Zhang R.   +6 more
europepmc   +1 more source

In‐Tip Nanoreactors for Simultaneous Proteolysis and Enrichment of Phosphorylated Peptides

Analytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT Protein phosphorylation introduces negative charges on the hydroxyl groups of serine, threonine, and tyrosine residues, reducing the ionization efficiency of phosphorylated peptides. The low abundance of phosphorylated peptides often diminishes their detection using mass spectrometry. To enhance the identification of the low‐abundance peptides,
Ling Yan
wiley   +1 more source

A Systematic Study of Lysine Succinylation in the Pathogenic Bacterium <i>Vibrio harveyi</i> in Aquatic Animals. [PDF]

Molecules
Yang S, Zhou P, Zhang W, Zhang Y, Guo H, Wei Y, Wen X, Jian J, Wang N, Pang H.   +9 more
europepmc   +1 more source

Current PAT Landscape in the Downstream Processing of Biopharmaceuticals

Analytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT Protein‐based therapeutics have revolutionized modern medicine, addressing complex diseases with unprecedented specificity and efficacy. The rising demand for biologics has driven the evolution of biomanufacturing practices to ensure consistent quality and operational efficiency.
Pavithra Sathiyapriyan, Shatanik Mukherjee, Thomas Vogel, Lars‐Oliver Essen, David Boerema, Martin Vey, Uwe Kalina   +6 more
wiley   +1 more source

Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy. [PDF]

Drug Des Devel Ther
Chen Y, Yue S, Yu L, Cao J, Liu Y, Deng A, Lu Y, Yang J, Li H, Du J, Xia J, Li Y, Xia Y.   +12 more
europepmc   +1 more source

Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies

MedComm, Volume 6, Issue 6, June 2025.
Lactylation, a novel post‐translational modification derived from lactate metabolism, plays a critical role in cellular homeostasis and disease pathogenesis. Under physiological conditions, lactylation regulates gene expression, immune responses, and metabolic adaptation. However, dysregulated lactylation is implicated in various pathological processes,
Xi Chen, Yixiao Yuan, Fan Zhou, Lihua Li, Jun Pu, Yong Zeng, Xiulin Jiang   +6 more
wiley   +1 more source