Results 51 to 60 of about 85,477 (330)

The Role of Post-Translational Modifications in Regulation of NLRP3 Inflammasome Activation

International Journal of Molecular Sciences, 2023
Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) induce NLRP3 inflammasome activation, and subsequent formation of active caspase-1 as well as the maturation of interleukin-1β (IL-1β) and gasdermin D (GSDMD),
Jing Xia, Songhong Jiang, Shiqi Dong, Yonghong Liao, Yang Zhou   +4 more
semanticscholar   +1 more source

Mechanisms of SOD1 regulation by post-translational modifications

Redox Biology, 2019
SOD1 is commonly known for its ROS scavenging activity, but recent work has uncovered additional roles in modulating metabolism, maintaining redox balance, and regulating transcription.
C.J. Banks, J.L. Andersen
doaj   +1 more source

Evolutionary Signals in Coronaviral Structural Proteins Suggest Possible Complex Mechanisms of Post-Translational Regulation in SARS-CoV-2 Virus

Viruses, 2022
Post-translational regulation of proteins has emerged as a central topic of research in the field of functional proteomics. Post-translational modifications (PTMs) dynamically control the activities of proteins and are involved in a wide range of ...
Ramiro Garza-Domínguez, Francisco Torres-Quiroz   +1 more
doaj   +1 more source

Functional analysis of protein post‐translational modifications using genetic codon expansion

Protein Science, 2023
Post‐translational modifications (PTMs) of proteins not only exponentially increase the diversity of proteoforms, but also contribute to dynamically modulating the localization, stability, activity, and interaction of proteins.
Tao Peng, Tandrila Das, Ke Ding, H. Hang
semanticscholar   +1 more source

How many human proteoforms are there? [PDF]

, 2018
Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which
Aebersold, Ruedi, Agar, Jeffrey N, Amster, I Jonathan, Baker, Mark S, Bertozzi, Carolyn R, Boja, Emily S, Costello, Catherine E, Cravatt, Benjamin F, Fenselau, Catherine, Garcia, Benjamin A, Ge, Ying, Gunawardena, Jeremy, Hendrickson, Ronald C, Hergenrother, Paul J, Huber, Christian G, Ivanov, Alexander R, Jensen, Ole N, Jewett, Michael C, Kelleher, Neil L, Kiessling, Laura L, Krogan, Nevan J, Larsen, Martin R, Loo, Joseph A, Lundberg, Emma, MacCoss, Michael J, Mallick, Parag, Mootha, Vamsi K, Mrksich, Milan, Muir, Tom W, Ogorzalek Loo, Rachel R, Patrie, Steven M, Pesavento, James J, Pitteri, Sharon J, Rodriguez, Henry, Saghatelian, Alan, Sandoval, Wendy, Schlüter, Hartmut, Sechi, Salvatore, Slavoff, Sarah A, Smith, Lloyd M, Snyder, Michael P, Thomas, Paul M, Uhlén, Mathias, Van Eyk, Jennifer E, Vidal, Marc, Walt, David R, White, Forest M, Williams, Evan R, Wohlschlager, Therese, Wysocki, Vicki H, Yates, Nathan A, Young, Nicolas L, Zhang, Bing   +52 more
core   +2 more sources

Advances in post-translational modifications of proteins and cancer immunotherapy

Frontiers in Immunology, 2023
Protein post-translational modification (PTM) is a regulatory mechanism for protein activity modulation, localization, expression, and interactions with other cellular molecules.
Yanqing Li, Runfang Zhang, H. Hei
semanticscholar   +1 more source

Proteome-wide profiling and mapping of post translational modifications in human hearts

Scientific Reports, 2021
Post translational modifications (PTMs) are covalent modifications of proteins that can range from small chemical modifications to addition of entire proteins.
Navratan Bagwan, Henrik H. El Ali, Alicia Lundby   +2 more
doaj   +1 more source

Epigenomes in Cardiovascular Disease. [PDF]

, 2018
If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA, Morimoto T, Poller W, Turner BM, Wang Y   +4 more
core   +1 more source

Novel Sarcopenia-related Alterations in Sarcomeric Protein Post-translational Modifications (PTMs) in Skeletal Muscles Identified by Top-down Proteomics*

Molecular & Cellular Proteomics, 2017
Sarcopenia, the age-related loss of skeletal muscle mass and strength, is a significant cause of morbidity in the elderly and is a major burden on health care systems.
Liming Wei, Zachery R. Gregorich, Ziqing Lin, Wenxuan Cai, Yutong Jin, S. McKiernan, S. McIlwain, J. Aiken, R. Moss, G. Diffee, Ying Ge   +10 more
semanticscholar   +1 more source

Protein Modifications as Potential Biomarkers in Breast Cancer

Biomarker Insights, 2009
A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry
Hongjun Jin, Richard C. Zangar
doaj   +2 more sources