Results 51 to 60 of about 76,851 (293)
PTM-ssMP: A Web Server for Predicting Different Types of Post-translational Modification Sites Using Novel Site-specific Modification Profile [PDF]
International Journal of Biological Sciences, 2018 Protein post-translational modifications (PTMs) are chemical modifications of a protein after its translation. Owing to its play an important role in deep understanding of various biological processes and the development of effective drugs, PTM site prediction have become a hot topic in bioinformatics.
Yu Liu +4 more
openalex +4 more sources
Frontiers in Molecular Neuroscience, 2021 Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic ...
Melanie J. Grubisha +3 more
doaj +1 more source
Investigation of the impact of PTMs on the protein backbone conformation [PDF]
Amino Acids, Springer Verlag, 2019, 51 (7), pp.1065-1079, 2019 Post-Translational Modifications (PTMs) are known to play a critical role in the regulation of the protein functions. Their impact on protein structures, and their link to disorder regions have already been spotted on the past decade. Nonetheless, the high diversity of PTMs types, and the multiple schemes of protein modifications (multiple PTMs, of ...
arxiv +1 more source
Development and optimization of a miniaturized western blot-based screening platform to identify regulators of post-translational modifications [PDF]
, 2019 Post-translational modifications (PTMs) are fundamental traits of protein functionality and their study has been addressed using several approaches over the past years.
Gottifredi, Vanesa +2 more
core +1 more source
Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. [PDF]
, 2011 Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs.
Arteaga-Salas, Jose M. +6 more
core +10 more sources
Proteome-wide profiling and mapping of post translational modifications in human hearts
Scientific Reports, 2021 Post translational modifications (PTMs) are covalent modifications of proteins that can range from small chemical modifications to addition of entire proteins.
Navratan Bagwan +2 more
doaj +1 more source
An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]
, 2015 Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro +1 more
core +1 more source
Roles of Post-translational Modifications in Spinocerebellar Ataxias
Frontiers in Cellular Neuroscience, 2018 Post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, SUMOylation, etc., of proteins can modulate protein properties such as intracellular distribution, activity, stability, aggregation, and interactions ...
Linlin Wan +14 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2022 In heart valve biology, organization of the extracellular matrix structure is directly correlated to valve function. This is especially true in cases of pediatric congenital aortic valve stenosis (pCAVS), in which extracellular matrix (ECM) dysregulation
Cassandra L. Clift +4 more
doaj +1 more source
Redox Biology, 2021 Thiol-based post-translational modifications (PTMs) play a key role in redox-dependent regulation and signaling. Functional cysteine (Cys) sites serve as redox switches, regulated through multiple types of PTMs.
Xiaolu Li +10 more
doaj