Nature Communications, 2016 Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and ...
Yang Yang +5 more
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Identifying Protein Interactions with Histone Peptides Using Bio-layer Interferometry
Bio-Protocol, 2018 Histone post-translational modifications (PTMs) regulate numerous cellular processes, including gene transcription, cell division, and DNA damage repair. Most histone PTMs affect the recruitment or exclusion of reader proteins from chromatin.
Bingbing Ren +4 more
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Turning the Knobs: The Impact of Post-translational Modifications on Carbon Metabolism
Frontiers in Plant Science, 2022 Plants rely on the carbon fixed by photosynthesis into sugars to grow and reproduce. However, plants often face non-ideal conditions caused by biotic and abiotic stresses.
Cleverson C. Matiolli +3 more
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PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data [PDF]
, 2014 Interactions among transcriptional factors (TFs), cofactors and other proteins or enzymes can affect transcriptional regulatory capabilities of eukaryotic organisms. Post-translational modifications (PTMs) cooperate with TFs and epigenetic alterations to
Boheler, KR +8 more
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The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma
Frontiers in Oncology, 2022 Merkel Cell Carcinoma (MCC) is a rare but highly aggressive form of non–melanoma skin cancer whose 5-year survival rate is 63%. Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, is the etiological agent of MCC.
C. Mazziotta +6 more
semanticscholar +1 more source
Fast and efficient digestion of adeno associated virus (AAV) capsid proteins for liquid chromatography mass spectrometry (LC-MS) based peptide mapping and post translational modification analysis (PTMs) [PDF]
, 2021 Felipe Guapo +4 more
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Post-Translational modifications and the effects on protein identification through mass spectrometry [PDF]
, 2005 only availableMass Spectrometry is an effective tool for protein identification. A typical process for protein identification is to break down a protein into smaller peptides and to determine the mass of each of these peptides.
Song, Zhao, 1978- +2 more
core
Post-Translational Modifications of STING: A Potential Therapeutic Target
Frontiers in Immunology, 2022 Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing essential roles in immune responses against microbial infections.
Jiaqi Kang +5 more
semanticscholar +1 more source
CellsAndrogen receptor (AR) transcriptional activity significantly influences prostate cancer (PCa) progression. In addition to ligand stimulation, AR transcriptional activity is also influenced by a variety of post-translational modifications (PTMs).
Lance Edward V. Lumahan +3 more
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Post-translational modifications of EZH2 in cancer
Cell & Bioscience, 2020 Enhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 upregulation results in cancer development and poor prognosis of cancer patients.
Zhongwei Li +8 more
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