Molecular model of postsynaptic potential. [PDF]
Proceedings of the National Academy of Sciences, 1975 A molecular model of the excitatory postsynaptic membrane is given in terms of two biochemical cycles intimately associated: an acetylcholine cycle and a calcium cycle. The acetylcholine controls the Na ionophores while calcium ions control the tk ionophore.
D. Dubois, E. Schoffeniels
semanticscholar +4 more sources
Imperfect space clamp permits electrotonic interactions between inhibitory and excitatory synaptic conductances, distorting voltage clamp recordings. [PDF]
PLoS ONE, 2011 The voltage clamp technique is frequently used to examine the strength and composition of synaptic input to neurons. Even accounting for imperfect voltage control of the entire cell membrane ("space clamp"), it is often assumed that currents measured at ...
Alon Poleg-Polsky, Jeffrey S Diamond
doaj +1 more source
Inference on the effect of non homogeneous inputs in Ornstein-Uhlenbeck neuronal modeling
Mathematical Biosciences and Engineering, 2020 A non-homogeneous Ornstein-Uhlembeck (OU) diffusion process is considered as a model for the membrane potential activity of a single neuron. We assume that, in the absence of stimuli, the neuron activity is described via a time-homogeneous process with ...
Giuseppina Albano , Virginia Giorno
doaj +1 more source
AMPA Receptor Trafficking for Postsynaptic Potentiation [PDF]
Frontiers in Cellular Neuroscience, 2018 Long-term potentiation (LTP) of excitatory synaptic strength, which has long been considered a synaptic correlate for learning and memory, requires a fast recruitment of additional α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors (AMPARs) to the postsynaptic sites.
Mikyoung Park, Mikyoung Park
openaire +4 more sources
Postsynaptic neuronal activity promotes regeneration of retinal axons
Cell Reports, 2023 Summary: The wiring of visual circuits requires that retinal neurons functionally connect to specific brain targets, a process that involves activity-dependent signaling between retinal axons and their postsynaptic targets.
Supraja G. Varadarajan +5 more
doaj +1 more source
Pre & postsynaptic tuning of action potential timing by spontaneous GABAergic activity. [PDF]
PLoS ONE, 2011 Frequency and timing of action potential discharge are key elements for coding and transfer of information between neurons. The nature and location of the synaptic contacts, the biophysical parameters of the receptor-operated channels and their kinetics ...
Olivier Caillard
doaj +1 more source
NMDA Currents Modulate the Synaptic Input–Output Functions of Neurons in the Dorsal Nucleus of the Lateral Lemniscus in Mongolian Gerbils [PDF]
, 2011 Neurons in the dorsal nucleus of the lateral lemniscus (DNLL) receive excitatory and inhibitory inputs from the superior olivary complex (SOC) and convey GABAergic inhibition to the contralateral DNLL and the inferior colliculi.
Felmy, Felix +3 more
core +1 more source
Distribution of densin in neurons. [PDF]
PLoS ONE, 2018 Densin is a scaffold protein known to associate with key elements of neuronal signaling. The present study examines the distribution of densin at the ultrastructural level in order to reveal potential sites that can support specific interactions of ...
Ayse Dosemeci +3 more
doaj +1 more source
Transcranial focused ultrasound induces sustained synaptic plasticity in rat hippocampus
Brain Stimulation, 2022 Transcranial focused ultrasound (tFUS) neuromodulation provides a promising emerging non-invasive therapy for the treatment of neurological disorders.
Xiaodan Niu, Kai Yu, Bin He
doaj +1 more source
Facilitatory actions of guanidine on synaptic transmission in mammalian brain slices [PDF]
, 1979 Guanidine administration may be beneficial in the treatment of amyotrophic lateral sclerosis and related diseases; however, the actions of guanidine on the mammalian central nervous system have not been investigated.
Galvan, Martin +2 more
core +1 more source