Results 11 to 20 of about 365,257 (120)

Distribution of densin in neurons. [PDF]

open access: yesPLoS ONE, 2018
Densin is a scaffold protein known to associate with key elements of neuronal signaling. The present study examines the distribution of densin at the ultrastructural level in order to reveal potential sites that can support specific interactions of ...
Ayse Dosemeci   +3 more
doaj   +1 more source

Influence of Mpv17 on Hair-Cell Mitochondrial Homeostasis, Synapse Integrity, and Vulnerability to Damage in the Zebrafish Lateral Line

open access: yesFrontiers in Cellular Neuroscience, 2021
Noise exposure is particularly stressful to hair-cell mitochondria, which must produce enough energy to meet high metabolic demands as well as regulate local intracellular Ca2+ concentrations.
Melanie Holmgren   +2 more
doaj   +1 more source

Functional maps of neocortical local circuitry

open access: yesFrontiers in Neuroscience, 2007
This review aims to summarize data obtained with different techniques to provide a functional map of the local circuit connections made by neocortical neurones, a reference for those interested in cortical circuitry and the numerical information required
Alex M Thomson, Christophe Lamy
doaj   +1 more source

Modeling Calcium Dynamics and Inhibition Based Synaptic Plasticity in Dendritic Spines

open access: yesMathematical Modelling and Analysis, 2014
Inhibitory synapses through GABAergic channels not only change spine's calcium dynamics but also modulate postsynaptic current mediated through glutamate receptors.
Muhammad Dur-e-Ahmad
doaj   +1 more source

Brain Dystrophin in Duchenne Dystrophy

open access: yesPediatric Neurology Briefs, 1995
To define the potential pathogenic role of dystrophin deficiency in the cognitive impairment characteristic of Duchenne muscular dystrophy (DMD), the protein in brain cortical synapses of an 8-year-old patient examined at autopsy and an age-matched ...
J Gordon Millichap
doaj   +1 more source

Retrograde Synaptic Signaling Mediated by K+ Efflux through Postsynaptic NMDA Receptors

open access: yesCell Reports, 2013
Synaptic NMDA receptors (NMDARs) carry inward Ca2+ current responsible for postsynaptic signaling and plasticity in dendritic spines. Whether the concurrent K+ efflux through the same receptors into the synaptic cleft has a physiological role is not ...
Pei-Yu Shih   +7 more
doaj   +1 more source

Impairment Mechanisms and Intervention Approaches for Aged Human Neuromuscular Junctions

open access: yesFrontiers in Molecular Neuroscience, 2020
The neuromuscular junction (NMJ) is a chemical synapse formed between a presynaptic motor neuron and a postsynaptic muscle cell. NMJs in most vertebrate species share many essential features; however, some differences distinguish human NMJs from others ...
Yomna Badawi   +2 more
doaj   +1 more source

Occurrence of Ordered and Disordered Structural Elements in Postsynaptic Proteins Supports Optimization for Interaction Diversity

open access: yesEntropy, 2019
The human postsynaptic density is an elaborate network comprising thousands of proteins, playing a vital role in the molecular events of learning and the formation of memory.
Annamária Kiss-Tóth   +6 more
doaj   +1 more source

Differential Effects of D-Cycloserine and ACBC at NMDA Receptors in the Rat Entorhinal Cortex Are Related to Efficacy at the Co-Agonist Binding Site. [PDF]

open access: yesPLoS ONE, 2015
Partial agonists at the NMDA receptor co-agonist binding site may have potential therapeutic efficacy in a number of cognitive and neurological conditions. The entorhinal cortex is a key brain area in spatial memory and cognitive processing.
Alex M Lench   +2 more
doaj   +1 more source

GABAergic synaptic transmission regulates calcium influx during spike-timing dependent plasticity

open access: yesFrontiers in Synaptic Neuroscience, 2010
Coincident pre- and postsynaptic activity of hippocampal neurons alters the strength of gamma-aminobutyric acid (GABAA)-mediated inhibition through a Ca2+-dependent regulation of cation-chloride cotransporters.
Trevor Balena   +2 more
doaj   +1 more source

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