Results 31 to 40 of about 10,517,225 (330)

Rethinking the Role of Normalization and Residual Blocks for Spiking Neural Networks

Sensors, 2022
Biologically inspired spiking neural networks (SNNs) are widely used to realize ultralow-power energy consumption. However, deep SNNs are not easy to train due to the excessive firing of spiking neurons in the hidden layers.
Shin-ichi Ikegawa, Ryuji Saiin, Yoshihide Sawada, Naotake Natori   +3 more
doaj   +1 more source

Preparation of Pre- and Post-synaptic Density Fraction from Mouse Cortex

Bio-Protocol, 2013
The understanding of the organization of postsynaptic signaling systems at excitatory synapses has been aided by the identification of proteins in the postsynaptic density (PSD) fraction, a subcellular fraction enriched in structures with the morphology ...
Chengyong Shen, Yong-Jun Chen
doaj   +1 more source

Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins

Cell Reports, 2022
Summary: Neurexins (NRXNs) are key presynaptic cell adhesion molecules that regulate synapse formation and function via trans-synaptic interaction with postsynaptic ligands.
Takeshi Uemura, Emi Suzuki-Kouyama, Shiori Kawase, Taiga Kurihara, Misato Yasumura, Tomoyuki Yoshida, Shuya Fukai, Maya Yamazaki, Peng Fei, Manabu Abe, Masahiko Watanabe, Kenji Sakimura, Masayoshi Mishina, Katsuhiko Tabuchi   +13 more
doaj   +1 more source

Data compression of excitatory postsynaptic potentials

Electronics Letters, 2015
Reducing the size of biosignal data is important because a huge amount of data is made by various experiments. In this reported work excitatory postsynaptic potentials (EPSPs) which are one of the biosignal types are efficiently compressed. To the best of authors’ knowledge, EPSPs compression has not been studied yet. The EPSP signal has a feature that
Hyejin An, Hyun-Chool Shin, Se-Young Choi, Kab-Mun Cha   +3 more
openaire   +2 more sources

Nitric oxide signalling modulates synaptic inhibition in the superior paraolivary nucleus (SPN) via cGMP-dependent suppression of KCC2

Frontiers in Neural Circuits, 2014
Glycinergic inhibition plays a central role in the auditory brainstem circuitries involved in sound localization and in the encoding of temporal action potential firing patterns.
Lina eYassin, Susanne eRadtke-Schuller, Hila eAsraf, Benedikt eGrothe, Michal eHershfinkel, Ian D Forsythe, Conny eKopp-Scheinpflug   +6 more
doaj   +1 more source

Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex

eLife, 2020
In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the cerebellum.
Andreas Hoehne, Maureen H McFadden, David A DiGregorio   +2 more
doaj   +1 more source

Targeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease

Communications Biology, 2023
Individuals with Alzheimer Disease who develop psychotic symptoms (AD + P) experience more rapid cognitive decline and have reduced indices of synaptic integrity relative to those without psychosis (AD-P).
J. M. Krivinko, M. R. DeChellis-Marks, L. Zeng, P. Fan, O. L. Lopez, Y. Ding, L. Wang, J. Kofler, M. L. MacDonald, R. A. Sweet   +9 more
doaj   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

A Novel Optical Quantal Analysis of Miniature Events Reveals Enhanced Frequency Following Amyloid β Exposure

Frontiers in Cellular Neuroscience, 2020
Non-evoked miniature release of neurotransmitters is increasingly recognized as playing an important role in neural function and is implicated in synaptic plasticity, metaplasticity, and homeostasis.
Henry B. C. Taylor, Rudi Tong, Rudi Tong, Alexander F. Jeans, Nigel J. Emptage   +4 more
doaj   +1 more source

Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice

Molecular Brain, 2021
The SH3 and multiple ankyrin repeat domains 3 (Shank3) protein is a core organizer of the macromolecular complex in excitatory postsynapses, and its defects cause numerous synaptopathies, including autism spectrum disorders.
Chunmei Jin, Yeunkum Lee, Hyojin Kang, Kwon Jeong, Joori Park, Yinhua Zhang, Hyae Rim Kang, Ruiying Ma, Hyunyoung Seong, Yoonhee Kim, Hosung Jung, Jin Young Kim, Yoon Ki Kim, Kihoon Han   +13 more
doaj   +1 more source