Impairment Mechanisms and Intervention Approaches for Aged Human Neuromuscular Junctions
Frontiers in Molecular Neuroscience, 2020 The neuromuscular junction (NMJ) is a chemical synapse formed between a presynaptic motor neuron and a postsynaptic muscle cell. NMJs in most vertebrate species share many essential features; however, some differences distinguish human NMJs from others ...
Yomna Badawi +2 more
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Proceedings of the National Academy of Sciences of the United States of America, 1991 The original proposal that substance P is involved in the regulation of nociceptive information at the first sensory synapse in the spinal cord has been substantiated by a wide range of evidence, but definitive support has been lacking, due primarily to ...
Y. de Koninck, J. Henry
semanticscholar +1 more source
Entropy, 2019 The human postsynaptic density is an elaborate network comprising thousands of proteins, playing a vital role in the molecular events of learning and the formation of memory.
Annamária Kiss-Tóth +6 more
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Differential Effects of D-Cycloserine and ACBC at NMDA Receptors in the Rat Entorhinal Cortex Are Related to Efficacy at the Co-Agonist Binding Site. [PDF]
PLoS ONE, 2015 Partial agonists at the NMDA receptor co-agonist binding site may have potential therapeutic efficacy in a number of cognitive and neurological conditions. The entorhinal cortex is a key brain area in spatial memory and cognitive processing.
Alex M Lench +2 more
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Electrogenesis of the slow inhibitory postsynaptic potential in bullfrog sympathetic ganglia.
The Japanese Journal of Physiology, 1983 The ionic mechanisms of the slow surface positive (P)-potential and the slow inhibitory postsynaptic potential (IPSP), an intracellularly recorded P-potential in sympathetic ganglia, were analysed by means of sucrose-gap, intracellular microelectrode ...
T. Akasu, K. Koketsu
semanticscholar +1 more source
Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]
, 1993 Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer +60 more
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GABAergic synaptic transmission regulates calcium influx during spike-timing dependent plasticity
Frontiers in Synaptic Neuroscience, 2010 Coincident pre- and postsynaptic activity of hippocampal neurons alters the strength of gamma-aminobutyric acid (GABAA)-mediated inhibition through a Ca2+-dependent regulation of cation-chloride cotransporters.
Trevor Balena +2 more
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Regulation of Irregular Neuronal Firing by Autaptic Transmission [PDF]
, 2016 The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the ...
Chen, Mingming +9 more
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Human synapses show a wide temporal window for spike-timing-dependent plasticity
Frontiers in Synaptic Neuroscience, 2010 Throughout our lifetime, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience.
Guilherme T Silva +7 more
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Neuromodulation of Chemical Synaptic Transmission Driven by THz Photons
Research, 2022 Postsynaptic currents of chemical synapse are modulated by multitudinous neurotransmitters, such as acetylcholine, dopamine, glutamate, and γ-aminobutyric acid, many of which have been used in the treatment of neurological diseases.
Xiaoxuan Tan +3 more
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