Results 211 to 220 of about 2,645 (252)
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Acrylamides as potassium channel openers
Expert Opinion on Therapeutic Patents, 2007The acrylamide moiety is widely employed in medicinal chemistry for the design of bioactive molecule and, notably, it has served as a scaffold for a number of potassium channel modulators in recent...
Antonio Nardi, Søren-Peter Olesen
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Effects of potassium channel openers on single potassium channels in mouse skeletal muscle
Naunyn-Schmiedeberg's Archives of Pharmacology, 1990The patch-clamp technique was used to study the effects of the potassium channel openers cromakalim, pinacidil, RP 49356 and diazoxide on single potassium channels in mouse skeletal muscle. In excised patches in the inside-out configuration, one type of potassium channel, the ATP-sensitive potassium channel, could be activated by internally applied RP ...
R, Weik, B, Neumcke
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Is there a Therapeutic Future for ‘Potassium Channel Openers’?
Clinical Science, 19961. Potassium channels, which control cell electrical activity, are among the most regulated of all ion channels in biology. Promotion of activity in K+ channels by a wide range of physiological factors tends to stabilize cell function. 2. The discovery of synthetic molecules (e.g.
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The Potassium Channel Openers: A New Class of Vasorelaxants
Blood Vessels, 2008Cromakalim, pinacidil, nicorandil, diazoxide and RP- 49356 belong to the class of drugs termed potassium channel openers. In rat portal vein diazoxide, like cromakalim, abolished spontaneous mechanical and electrical activity and in rat aorta caused an increase in 86Rb efflux and inhibited KCl (20 mM)-induced contractions.
A H, Weston +5 more
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Endothelin Opens Potassium Channels in Glial Cells
European Journal of Neuroscience, 1991AbstractEndothelin‐1 (ET‐1), an autocrine hormone synthesized by astrocytes, and endothelin‐3 (ET‐3), a highly homologous peptide produced by neurons, have both been shown previously to cause proliferation of these astrocytes in culture [Supattapone et al. (1989) Biochem. Biophys. Res. Commun., 165, 1115–1122; MacCumber et al. (1990) Proc. Natl.
Surachai, Supattapone +1 more
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Recent progress in potassium channel opener pharmacology
Biochemical Pharmacology, 1992Potassium (K) channel openers comprise a diverse group of molecules capable of opening K channels in excitable cells. These agents exhibit their greatest potency in the smooth muscle system but K channels in cardiac muscle, neurones and in secretory cells are also affected.
A H, Weston, G, Edwards
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Opening the gate in potassium channels
Nature Structural & Molecular Biology, 2004Structural studies of potassium channels suggest that opening of the gate involves large changes in the intracellular pore aperture, leaving a pore diameter >12 A. A recent mechanistic study on eukaryotic voltage-activated potassium channels points to an alternative picture of opening, including a smaller open pore and possibly a unique hinge or swivel
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Peripheral channelopathies as targets for potassium channel openers
Expert Opinion on Investigational Drugs, 2001Potassium channel openers (KCOs) are important tools that are often used to gain a greater understanding of K(+) channels. Agents that can induce or maintain the opening of K(+) channels also offer a therapeutic approach to controlling of cell excitability and offer a means of producing stability in biological systems. The pathogenesis of a broad range
Lawson, K., Dunne, M. J.
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Recent Developments on KCNQ Potassium Channel Openers
Current Medicinal Chemistry, 2005During the past five years, several members of the KCNQ potassium channel gene family have been identified with a high degree of CNS specificity. Within the KCNQ family, the combination of the KCNQ2/KCNQ3 proteins, and the KCNQ5/KCNQ3 arrangement has been identified as the molecular correlates of the different M-currents.
Yong-Jin, Wua, Steven I, Dworetzky
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Potassium channel openers depolarize hippocampal mitochondria
Brain Research, 2001We investigated the effect of the potassium channel openers diazoxide and RP66471 on mitochondrial membrane potential and mitochondrial respiration in digitonin-treated rat hippocampal homogenates. Both diazoxide and RP66471 induced a dose-dependent decrease of mitochondrial membrane potential.
G, Debska +5 more
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