Results 211 to 220 of about 1,524,654 (239)

Antigen‐Detected NMR for Minimal Epitope Engineering and Structure‐Guided Selection of a NaV1.7‐Selective Nanobody

Advanced Science, EarlyView.
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Junyu Liu, Wanlin Chen, Ben Cristofori‐Armstrong, Theo Crawford, Kai‐En Chen, Peng Xie, Rainbow Wing Bo Chan, Yifei Zhu, Mimi Golder, Anneka Pereira Schmidt, Jennifer D. Naughton, Nicholas D. Condon, Åsa Andersson, Farhad Dehkhoda, Kirsten L. McMahon, Tabea Klasfauseweh, Ashvriya Thapa, Hue Tran, Poanna Tran, Sina Jami, Lotten Ragnarsson, Sebastian G. B. Furness, Jennifer R. Deuis, Brett M. Collins, Wai‐Hong Tham, Indira Prasadam, Irina Vetter, Mehdi Mobli   +27 more
wiley   +1 more source

Nonsteroidal Anti-Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies. [PDF]

ChemMedChem
Laghetti P, Altamura C, Dell'Atti S, Desaphy JF, Saltarella I.   +4 more
europepmc   +1 more source

Hybrid Metal–Organic Framework‐Derived Dual Active Site Catalysts Enabling Surface‐Enriched Cathode and Modified Zinc Anode for Long‐Life Zinc–Air Batteries

Advanced Science, EarlyView.
This work demonstrates the implementation of MOF‐assisted anode and cathode materials for prolonged cycling of zinc‐air batteries with strong redox capability and structural stability. ABSTRACT The surface modification of zinc anodes and the development of effective cathode dual‐functional oxygen electrocatalysts remain of paramount interest for ...
Ramasamy Santhosh Kumar, Duraisami Kaviyarasu, Dilmurod Sayfiddinov, Murugavel Kathiresan, Pandian Mannu, Chung‐Li Dong, Arul Manuel Stephan, Dong Jin Yoo   +7 more
wiley   +1 more source

Treatment updates in myotonic disorders. [PDF]

J Neurol
Matthews E, Specterman MJ, Mul K.
europepmc   +1 more source

K_V3.1 channel modulation: a systematic review of pharmacological intervention strategies. [PDF]

Front Pharmacol
Nuñez E, Muguruza-Montero A, Arrizabalaga-Iriondo A, Zayas-Arrabal J, M-Alicante S, Urrutia J, Revuelta M.   +6 more
europepmc   +1 more source

Mechanisms Underlying the Biphasic Effects of Hydrogen Sulfide in Rat Intrapulmonary Arteries. [PDF]

Biomedicines
Tunaitytė A, Alan E, Aleknavičius A, Abramavičius S, Simonsen U, Stankevičius E.   +5 more
europepmc   +1 more source

Progress in the study of ion channel function, mechanisms, and mathematical modeling in Parkinson's disease. [PDF]

iScience
Wang R, Zeng X, Zhang Z, Ma D.
europepmc   +1 more source

Efficacy of a K⁺ Channel Agonist, XEN1101, For Preserving Contractility in Mouse Models of Hypokalemic Periodic Paralysis. [PDF]

Muscle Nerve
Chanchykov V, Iype S, Quinonez M, Wu F, Cannon S.   +4 more
europepmc   +1 more source

KCNT1 (Slack/Slo2.2) and KCNT2 (Slick/Slo2.1) Dysregulation in Intellectual Disability and Behavioral Phenotypes: A Systematic Review. [PDF]

Cureus
Murugesan K, Kabir A, Tomalieh BT, Torres J, Kasagga A, Rebellow D.   +5 more
europepmc   +1 more source