Results 221 to 230 of about 2,645 (252)

Current trends in the study of potassium channel openers

General Pharmacology: The Vascular System, 1993
Some eight years ago it was found that certain smooth muscle relaxants exert their effect by opening a specific K+ channel resulting in cell membrane hyperpolarization. The use of K+ channel openers (cromakalim, pinacidil and RP-52891) and compounds which antagonize their actions (glibenclamide, phentolamine and alinidine) has enabled a great deal of ...
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OPENING OF MITOCHONDRIAL POTASSIUM CHANNELS

Transplantation, 2000
This study was designed to assess the protective effects of the mitochondrial adenosine triphosphate-sensitive potassium channel (KATP) opener diazoxide as an additive to heart preservation solution.Forty isolated isovolumic buffer-perfused rat hearts were divided into four groups.
E, Kevelaitis, A, Oubenaissa, C, Mouas, J, Peynet, P, Menasché   +4 more
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Potassium Channel Openers in Myocardial Ischaemia

Drugs, 2001
Potassium channel openers or agonists represent a novel new class of compounds in the treatment of a range of cardiovascular disorders, particularly angina pectoris and hypertension. Nicorandil is the only clinically available potassium channel opener with antianginal effects, and with comparable efficacy and tolerability to existing antianginal ...
A H, Gomma, H J, Purcell, K M, Fox
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Potassium channel openers: pharmacological and clinical aspects

Fundamental & Clinical Pharmacology, 1992
Summary—Opening of plasmalemmal K+ channels leads to cellular hyperpolarization which, in excitable tissues possessing voltage‐dependent Ca2+channels, prevents the opening of such channels and thus prevents excitation. In the last few years, an increasing number of compounds have been identified which elicit their effects by opening K+ channels ...
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Potassium Channel Opening and Coronary Vasodilation by Halothane

1994
Publisher Summary This chapter discusses the studies on halothane vasodilation in the presence and absence of glyburide or 5-hydroxydecanoate (5-HD), pharmacological blockers of ATP-sensitive K+ channels (K ATP ) to establish whether halothane relaxes intact epicardial coronary arteries by opening vascular smooth muscle (VSM) K + channels. Halothane
D R, Larach, H G, Schuler, K A, Zangari, R L, McCann   +3 more
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Chapter 9. Potassium Channel Openers

1995
Publisher Summary The science of potassium channels is in a very exciting phase. Potassium (K+) channels play a central role in the regulation of cellular excitability. They are involved in setting the membrane potential, in addition to controlling the frequency and shape of action potentials.
James R. Empfield, Keith Russell
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Potassium Channel Openers and Cardiac Surgery

1997
Cardiac operations offer the unique possibility of precisely planning the time at which the aortic crossclamp will be applied, thereby initiating the period of global ischemia. This provides the opportunity of using the timely implementation of preconditioning strategies as a novel approach to intraoperative myocardial protection based on the ...
Louis P. Perrault, Philippe Menasché
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Potassium Channel Openers

Drugs, 1990
S, Duty, A H, Weston
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Potassium channel openers and asthma

Clinical Reviews in Allergy, 1994
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Potassium Channel Openers

2001
John R. Fozard, Paul W. Manley
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