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Modulatory Effects of "Minor" Cannabinoids in an in vitro Model of Neuronal Hypersensitivity. [PDF]
J Pain ResAnand U, Anand P, Sodergren MH.
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Drugs to affect the smooth musculature of the human ureter - an update with integrated information from basic science to the use in medical expulsion therapy (MET). [PDF]
World J UrolHedlund P +4 more
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Pharmacology of the potassium channel openers
Cardiovascular Drugs and Therapy, 1995The potassium-channel openers comprise a large number of molecules that can be classified into three basic groups: (1) agents like levcromakalim that open a small-conductance (10-30 pS) glibenclamide-sensitive K+ channel currently known as the ATP-sensitive K+ channel, KATP; (2) hybrid molecules, such as nicorandil, that open KATP channels and that ...
G, Edwards, A H, Weston
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Cardioprotective Actions of Potassium Channel Openers
European Heart Journal, 1994The potential cardioprotective effect of two pure potassium channel openers, bimakalim (EMD 52692) and aprikalim (RP 52891), on myocardial ischaemia/reperfusion injury was investigated in barbital-anaesthetized dogs. In a model of reversible ischaemia/reperfusion injury, administration of bimakalim as an intravenous bolus prior to ischaemia or ...
J A, Auchampach, M, Maruyama, G J, Gross
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Electrophysiologic effects of potassium channel openers
Cardiovascular Drugs and Therapy, 1995Potassium-channel openers or activators have been introduced as a new class of antihypertensive and antianginal agents that act by increasing membrane conductance to potassium, mainly through augmentation of the ATP-sensitive potassium current. Recent in vitro studies have shown that K(+)-channel openers exert concentration-dependent effects on cardiac
W, Haverkamp +2 more
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Stoichiometry of Potassium Channel Opener Action
Molecular Pharmacology, 1999Potassium channel openers (KCOs; e.g., P1075, pinacidil) exert their effects on excitable cells by opening ATP-sensitive potassium channels. These channels are heteromultimers composed with a 4:4 stoichiometry of an inwardly rectifying K(+) channel subunit plus a regulatory subunit comprising the receptor sites for hypoglycemic sulfonylureas and KCOs ...
I, Gross +4 more
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Potassium channel openers depolarize hippocampal mitochondria
Brain Research, 2001We investigated the effect of the potassium channel openers diazoxide and RP66471 on mitochondrial membrane potential and mitochondrial respiration in digitonin-treated rat hippocampal homogenates. Both diazoxide and RP66471 induced a dose-dependent decrease of mitochondrial membrane potential.
G, Debska +5 more
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Acrylamides as potassium channel openers
Expert Opinion on Therapeutic Patents, 2007The acrylamide moiety is widely employed in medicinal chemistry for the design of bioactive molecule and, notably, it has served as a scaffold for a number of potassium channel modulators in recent...
Antonio Nardi, Søren-Peter Olesen
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Dihydropyridine KATP potassium channel openers
Bioorganic & Medicinal Chemistry Letters, 1993Abstract Three related series of dihydropyridine K ATP potassium channel openers are described.
C.A. Frank +9 more
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Benzopyranyl-cyanoguanidine potassium channel openers
Bioorganic & Medicinal Chemistry Letters, 1992Abstract To further investigate whether potassium channel operators cromakalim (1) and pinacidil (2) share common pharmacophoric features, the cyanoguanidine analog 4a of cromakalim (1) was prepared and evaluated for biological activity. the potent vasorelaxing activity displayed by 4a and some of its analogs support the hypothesis that cromakalim (1)
Karnail S. Atwal +4 more
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