Results 251 to 260 of about 5,395 (299)
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Aryl cyanoguanidine potassium channel openers
Bioorganic & Medicinal Chemistry Letters, 1992Abstract To investigate whether potassium channel openers cromakalim ( 1 ) and pinacidil ( 2 ) share common pharmacophoric features, the combination compound 6a was prepared and evaluated for biological activity. The potent vasorelaxant/antihypertensive activity displayed by 6a and some of its analogs suggest cromakalim ( 1 ) and pinacidil ( 2 ...
Karnail S. Atwal +5 more
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Mitochondria and Big-Conductance Potassium Channel Openers
Toxicology Mechanisms and Methods, 2004Mitochondria play a central role in energy generation within the cell. Since the discovery of potassium channels in the inner mitochondrial membrane, mitochondria have been considered an important target for potassium channel openers. The purpose of this short review is to present the recent state of our knowledge about big-conductance potassium ...
Anna, Kicinska +2 more
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The open pore conformation of potassium channels
Nature, 2002Living cells regulate the activity of their ion channels through a process known as gating. To open the pore, protein conformational changes must occur within a channel's membrane-spanning ion pathway. KcsA and MthK, closed and opened K(+) channels, respectively, reveal how such gating transitions occur.
Jiang, Youxing +5 more
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Potassium Channel Openers: The Case of BK Channel Activators
Letters in Drug Design & Discovery, 2006Large-conductance calcium-activated potassium channels, also known as BK or Maxi-K channels, occur in many types of cells, where they play an essential role in the regulation of cell excitability and function. BK channel openers constitute a heterogeneous group of organic compounds being able to activate BK channels and having a wide therapeutic ...
Nardi A, CALDERONE, VINCENZO, Olesen SP
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Recent progress in potassium channel opener pharmacology
Biochemical Pharmacology, 1992Potassium (K) channel openers comprise a diverse group of molecules capable of opening K channels in excitable cells. These agents exhibit their greatest potency in the smooth muscle system but K channels in cardiac muscle, neurones and in secretory cells are also affected.
A H, Weston, G, Edwards
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Clinical Pharmacology of Potassium Channel Openers
Pharmacology & Toxicology, 1992Abstract:Opening of K+channels in cell membranes with resulting increase in K+conductance, shifts the membrane potential in a hyperpolarizing direction towards the K+equilibrium potential. Hyperpolarization reduces the opening probability of ion channels involved in membrane depolarization and excitation is reduced.
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Recent Developments on KCNQ Potassium Channel Openers
Current Medicinal Chemistry, 2005During the past five years, several members of the KCNQ potassium channel gene family have been identified with a high degree of CNS specificity. Within the KCNQ family, the combination of the KCNQ2/KCNQ3 proteins, and the KCNQ5/KCNQ3 arrangement has been identified as the molecular correlates of the different M-currents.
Yong-Jin, Wua, Steven I, Dworetzky
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Endothelin Opens Potassium Channels in Glial Cells
European Journal of Neuroscience, 1991AbstractEndothelin‐1 (ET‐1), an autocrine hormone synthesized by astrocytes, and endothelin‐3 (ET‐3), a highly homologous peptide produced by neurons, have both been shown previously to cause proliferation of these astrocytes in culture [Supattapone et al. (1989) Biochem. Biophys. Res. Commun., 165, 1115–1122; MacCumber et al. (1990) Proc. Natl.
Surachai, Supattapone +1 more
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Potassium channel openers accelerate epidermal barrier recovery
British Journal of Dermatology, 2007Maintenance of a competent permeability barrier in the face of external and internal stressors requires signals between the stratum corneum interface and the metabolic machinery in the underlying nucleated layers. For example, reductions in the ion gradients for Ca2+ after acute barrier disruption stimulate lamellar body (LB) secretion, a response ...
M, Denda +5 more
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Chapter 9. Potassium Channel Openers
1995Publisher Summary The science of potassium channels is in a very exciting phase. Potassium (K+) channels play a central role in the regulation of cellular excitability. They are involved in setting the membrane potential, in addition to controlling the frequency and shape of action potentials.
James R. Empfield, Keith Russell
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