Results 1 to 10 of about 353,299 (301)

Ca²⁺-Sensitive Potassium Channels

Molecules, 2023
The Ca2+ ion is used ubiquitously as an intracellular signaling molecule due to its high external and low internal concentration. Many Ca2+-sensing ion channel proteins have evolved to receive and propagate Ca2+ signals. Among them are the Ca2+-activated
Razan Orfali, Nora Albanyan
doaj   +3 more sources

Potassium channels in depression: emerging roles and potential targets [PDF]

Cell & Bioscience
Potassium ion channels play a fundamental role in regulating cell membrane repolarization, modulating the frequency and shape of action potentials, and maintaining the resting membrane potential.
Jiahao Zhang, Yao Zhu, Meng Zhang, Jinglan Yan, Yuanjia Zheng, Lin Yao, Ziwei Li, Zihan Shao, Yongjun Chen   +8 more
doaj   +2 more sources

Pharmacological Actions of Potassium Channel Openers on Voltage-Gated Potassium Channels [PDF]

Pharmaceuticals
Background/Objectives: Potassium (K+) channels are essential transmembrane proteins that regulate ion flow, playing a critical role in regulating action potentials and neuronal transmission.
Michael T. McCoy, Bruce Ladenheim, Jean Lud Cadet, Atul P. Daiwile   +3 more
doaj   +2 more sources

Current Challenges of Mitochondrial Potassium Channel Research

Frontiers in Physiology, 2022
In this paper, the current challenges of mitochondrial potassium channels research were critically reviewed. Even though recent progress in understanding K+ traffic in mitochondria has been substantial, some basic issues of this process remain unresolved.
Bogusz Kulawiak, Adam Szewczyk
doaj   +1 more source

Alternative Targets for Modulators of Mitochondrial Potassium Channels

Molecules, 2022
Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of reactive oxygen species (ROS).
Antoni Wrzosek, Shur Gałecka, Monika Żochowska, Anna Olszewska, Bogusz Kulawiak   +4 more
doaj   +1 more source

Involvement of Potassium Channel Signalling in Migraine Pathophysiology

Pharmaceuticals, 2023
Migraine is a primary headache disorder ranked as the leading cause of years lived with disability among individuals younger than 50 years. The aetiology of migraine is complex and might involve several molecules of different signalling pathways ...
Mohammad Al-Mahdi Al-Karagholi
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Drunk potassium channels [PDF]

Europace, 2011
We report the case of a 42-year-old woman who was admitted due to alcohol induced dehydration leading to cardiac symptoms. On physical examination severe hypokalaemia and long QT syndrome were apparent. During potassium (K+) supplementation we simultaneously observed QT interval recovery.
Amir M, Nia, Natig, Gassanov, Marcos, Ortega, Fikret, Er   +3 more
openaire   +2 more sources

Hydrogen Sulfide-Induced Vasodilation: The Involvement of Vascular Potassium Channels

Frontiers in Pharmacology, 2022
Hydrogen sulfide (H2S) has been highlighted as an important gasotransmitter in mammals. A growing number of studies have indicated that H2S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis. Alteration in
Xiao-Yu Liu, Ling-Ling Qian, Ru-Xing Wang   +2 more
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Potassium channels [PDF]

FEBS Letters, 2003
The atomic structures of K+ channels have added a new dimension to our understanding of K+ channel function. I will briefly review how structures have influenced our views on ion conduction, gating of the pore, and voltage sensing.
openaire   +3 more sources

Mitochondrial Potassium Channels as Druggable Targets

Biomolecules, 2020
Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have ...
Antoni Wrzosek, Bartłomiej Augustynek, Monika Żochowska, Adam Szewczyk   +3 more
doaj   +1 more source