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Mitochondrial Potassium Channels as Druggable Targets
Biomolecules, 2020 Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have ...
Antoni Wrzosek +3 more
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Potassium Channels in Epilepsy. [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 This review attempts to give a concise and up-to-date overview on the role of potassium channels in epilepsies. Their role can be defined from a genetic perspective, focusing on variants and de novo mutations identified in genetic studies or animal models with targeted, specific mutations in genes coding for a member of the large potassium channel ...
R. Köhling, Jakob Wolfart
semanticscholar +3 more sources
The neuroglial potassium cycle during neurotransmission: role of Kir4.1 channels. [PDF]
PLoS Computational Biology, 2015 Neuronal excitability relies on inward sodium and outward potassium fluxes during action potentials. To prevent neuronal hyperexcitability, potassium ions have to be taken up quickly.
Jérémie Sibille +3 more
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Ca2+-Sensitive Potassium Channels
Molecules, 2023 The Ca2+ ion is used ubiquitously as an intracellular signaling molecule due to its high external and low internal concentration. Many Ca2+-sensing ion channel proteins have evolved to receive and propagate Ca2+ signals. Among them are the Ca2+-activated
Razan Orfali, Nora Albanyan
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Structure of potassium channels [PDF]
Cellular and Molecular Life Sciences, 2015 Potassium channels ubiquitously exist in nearly all kingdoms of life and perform diverse but important functions. Since the first atomic structure of a prokaryotic potassium channel (KcsA, a channel from Streptomyces lividans) was determined, tremendous ...
Qie Kuang, P. Purhonen, H. Hebert
semanticscholar +3 more sources
Frontiers in Molecular Neuroscience, 2018 Within the potassium ion channel family, calcium activated potassium (KCa) channels are unique in their ability to couple intracellular Ca2+ signals to membrane potential variations.
Aravind S. Kshatri +5 more
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Potassium channels in depression: emerging roles and potential targets [PDF]
Cell & BiosciencePotassium ion channels play a fundamental role in regulating cell membrane repolarization, modulating the frequency and shape of action potentials, and maintaining the resting membrane potential.
Jiahao Zhang +8 more
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Pharmacological Actions of Potassium Channel Openers on Voltage-Gated Potassium Channels [PDF]
PharmaceuticalsBackground/Objectives: Potassium (K+) channels are essential transmembrane proteins that regulate ion flow, playing a critical role in regulating action potentials and neuronal transmission.
Michael T. McCoy +3 more
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Current Challenges of Mitochondrial Potassium Channel Research
Frontiers in Physiology, 2022 In this paper, the current challenges of mitochondrial potassium channels research were critically reviewed. Even though recent progress in understanding K+ traffic in mitochondria has been substantial, some basic issues of this process remain unresolved.
Bogusz Kulawiak, Adam Szewczyk
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Involvement of Potassium Channel Signalling in Migraine Pathophysiology
Pharmaceuticals, 2023 Migraine is a primary headache disorder ranked as the leading cause of years lived with disability among individuals younger than 50 years. The aetiology of migraine is complex and might involve several molecules of different signalling pathways ...
Mohammad Al-Mahdi Al-Karagholi
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