Results 1 to 10 of about 234,892 (239)
Potassium channels in depression: emerging roles and potential targets [PDF]
Cell & BiosciencePotassium ion channels play a fundamental role in regulating cell membrane repolarization, modulating the frequency and shape of action potentials, and maintaining the resting membrane potential.
Jiahao Zhang +8 more
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Voltage-gated potassium channels as a potential therapeutic target for the treatment of neurological and psychiatric disorders [PDF]
Frontiers in Cellular NeuroscienceVoltage-gated potassium channels are a widely distributed subgroup of potassium channels responsible for the efflux of potassium in the repolarisation of the cell membrane, and hence contribute to the latency and propagation of action potentials. As they
Isabel E. Faulkner +4 more
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Peptide Toxins from Marine Conus Snails with Activity on Potassium Channels and/or Currents [PDF]
ToxinsToxins from Conus snails are peptides characterized by a great structural and functional diversity. They have a high affinity for a wide range of membrane proteins such as ion channels, neurotransmitter transporters, and G protein-coupled receptors ...
Luis Martínez-Hernández +2 more
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Ca2+-Sensitive Potassium Channels
Molecules, 2023 The Ca2+ ion is used ubiquitously as an intracellular signaling molecule due to its high external and low internal concentration. Many Ca2+-sensing ion channel proteins have evolved to receive and propagate Ca2+ signals. Among them are the Ca2+-activated
Razan Orfali, Nora Albanyan
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Current Challenges of Mitochondrial Potassium Channel Research
Frontiers in Physiology, 2022 In this paper, the current challenges of mitochondrial potassium channels research were critically reviewed. Even though recent progress in understanding K+ traffic in mitochondria has been substantial, some basic issues of this process remain unresolved.
Bogusz Kulawiak, Adam Szewczyk
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Involvement of Potassium Channel Signalling in Migraine Pathophysiology
Pharmaceuticals, 2023 Migraine is a primary headache disorder ranked as the leading cause of years lived with disability among individuals younger than 50 years. The aetiology of migraine is complex and might involve several molecules of different signalling pathways ...
Mohammad Al-Mahdi Al-Karagholi
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Alternative Targets for Modulators of Mitochondrial Potassium Channels
Molecules, 2022 Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of reactive oxygen species (ROS).
Antoni Wrzosek +4 more
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Structure of potassium channels [PDF]
Cellular and Molecular Life Sciences, 2015 Potassium channels ubiquitously exist in nearly all kingdoms of life and perform diverse but important functions. Since the first atomic structure of a prokaryotic potassium channel (KcsA, a channel from Streptomyces lividans) was determined, tremendous progress has been made in understanding the mechanism of potassium channels and channels conducting ...
Pasi Purhonen +4 more
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Hydrogen Sulfide-Induced Vasodilation: The Involvement of Vascular Potassium Channels
Frontiers in Pharmacology, 2022 Hydrogen sulfide (H2S) has been highlighted as an important gasotransmitter in mammals. A growing number of studies have indicated that H2S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis. Alteration in
Xiao-Yu Liu +2 more
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Mitochondrial Potassium Channels as Druggable Targets
Biomolecules, 2020 Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have ...
Antoni Wrzosek +3 more
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