Results 1 to 10 of about 171,305 (316)

KCNQs: Ligand- and Voltage-Gated Potassium Channels [PDF]

Frontiers in Physiology, 2020
Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a broad range of excitable and non-excitable cell types and are found in organisms ranging from Hydra vulgaris to Homo sapiens.
Geoffrey W. Abbott
doaj   +6 more sources

Direct neurotransmitter activation of voltage-gated potassium channels [PDF]

Nature Communications, 2018
M-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine.
Rían W. Manville, Maria Papanikolaou, Geoffrey W. Abbott   +2 more
doaj   +6 more sources

Mechanism of electromechanical coupling in voltage-gated potassium channels [PDF]

Frontiers in Pharmacology, 2012
Voltage-gated ion channels play a central role in the generation of action potentials in the nervous system. They are selective for one type of ion – sodium, calcium or potassium. Voltage-gated ion channels are composed of a central pore that allows ions
Rikard eBlunck, Rikard eBlunck, Zarah eBatulan, Zarah eBatulan   +3 more
doaj   +4 more sources

Voltage-Gated Potassium Channels as Regulators of Cell Death

Frontiers in Cell and Developmental Biology, 2020
Ion channels allow the flux of specific ions across biological membranes, thereby determining ion homeostasis within the cells. Voltage-gated potassium-selective ion channels crucially contribute to the setting of the plasma membrane potential, to volume
Magdalena Bachmann, Magdalena Bachmann, Weiwei Li, Michael J. Edwards, Syed A. Ahmad, Sameer Patel, Ildiko Szabo, Ildiko Szabo, Erich Gulbins, Erich Gulbins   +9 more
doaj   +2 more sources

MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain

Nature Communications, 2017
Dysregulation of voltage gated potassium channels is a feature of neuropathic pain. Here in a rat model the authors identify the microRNA cluster miR-17-92 as a regulator of voltage gated potassium channels in the dorsal root ganglion neurons.
Atsushi Sakai, Fumihito Saitow, Motoyo Maruyama, Noriko Miyake, Koichi Miyake, Takashi Shimada, Takashi Okada, Hidenori Suzuki   +7 more
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Pharmacological Actions of Potassium Channel Openers on Voltage-Gated Potassium Channels [PDF]

Pharmaceuticals
Background/Objectives: Potassium (K+) channels are essential transmembrane proteins that regulate ion flow, playing a critical role in regulating action potentials and neuronal transmission.
Michael T. McCoy, Bruce Ladenheim, Jean Lud Cadet, Atul P. Daiwile   +3 more
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The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms

Frontiers in Cellular Neuroscience, 2017
Neurons are highly polarized cells with apparent functional and morphological differences between dendrites and axon. A critical determinant for the molecular and functional identity of axonal and dendritic segments is the restricted expression of ...
Jeffrey Lopez-Rojas, Maël Duménieu, Marie Oulé, Michael R. Kreutz, Michael R. Kreutz   +4 more
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Developmental expression of Kv potassium channels at the axon initial segment of cultured hippocampal neurons. [PDF]

PLoS ONE, 2012
Axonal outgrowth and the formation of the axon initial segment (AIS) are early events in the acquisition of neuronal polarity. The AIS is characterized by a high concentration of voltage-dependent sodium and potassium channels.
Diana Sánchez-Ponce, Javier DeFelipe, Juan José Garrido, Alberto Muñoz   +3 more
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The role of axonal voltage-gated potassium channels in tDCS

Brain Stimulation, 2022
Background: Transcranial direct current stimulation (tDCS) is a non-invasive sub-threshold stimulation, widely accepted for its amelioration of distinct neuropsychiatric disorders.
Sreerag Othayoth Vasu, Hanoch Kaphzan
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Modeling the kinetics of heteromeric potassium channels

Frontiers in Cellular Neuroscience, 2022
Mechanistic mathematical modeling has long been used as a tool for answering questions in cellular physiology. To mathematically describe cellular processes such as cell excitability, volume regulation, neurotransmitter release, and hormone secretion ...
Kees McGahan, James Keener
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