Results 141 to 150 of about 57,429 (242)

Modular Model of Neuronal Activity That Captures the Dynamics of Main Molecular Targets of Antiepileptic Drugs. [PDF]

Int J Mol Sci
Kondrakhin PY, Kolpakov FA.
europepmc   +1 more source

Ion Channel-Targeting Toxins: Structural Mechanisms of Activation, Inhibition, and Therapeutic Potential. [PDF]

Toxins (Basel)
Aoki-Shioi N, Nomura S, Tanaka Y, Hirose S.   +3 more
europepmc   +1 more source

Bioinformatics‐Driven Design and Evaluation of Recombinant Multi‐Epitope Immunogens Derived From Snake Venom Toxins as Potential Antivenom Candidates

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley   +1 more source

Immature olfactory sensory neurons are intrinsically excitable and show maturation-dependent changes in voltage-gated Na⁺ and K⁺ currents. [PDF]

Pflugers Arch
Ricci C, Sánchez Triviño CA, Rangaswamy U, Tortella L, Sanges R, Boccaccio A, Menini A.   +6 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Impaired excitability of fast-spiking neurons in a novel mouse model of <i>KCNC1</i> epileptic encephalopathy. [PDF]

Elife
Wengert ER, Liebergall SR, Jimenez T, Cheng MA, Markwalter KH, Clatot J, Hong Y, Arias L, Marsh ED, Zhang X, Tsetsenis T, Somarowthu A, Akizu N, Goldberg EM.   +13 more
europepmc   +1 more source

G Protein–Coupled Receptors in Olfactory Signaling and Related Disorders: Mechanisms and Therapeutic Implications

Sensory Neuroscience, EarlyView.
This schematic highlights GPCRs as the central hub of olfactory signaling in health and disease. The central GPCR shows odorant activation and downstream pathways. Surrounding quadrants illustrate four GPCR‐mediated themes: odor perception and adaptation, mucosal immunity and regeneration, memory consolidation via neural circuits, and GPCR‐related ...
Zishuo Guo, Hongjie Du, Fanyu Yuan, Yuhan Dong, Fangyuan Zhu, Jian Liu, Chengzhilin Li, Xu Guo, Zhaoze Yang, Wenwen Qi, Ming Xia, Chengcheng Liu   +11 more
wiley   +1 more source

A random-walk-based learning framework to uncover novel gene candidates for Alzheimer's disease therapy. [PDF]

Pac Symp Biocomput
Orlenko A, Li B, Khanjani N, Venkatesan M, Shen L, Ritchie MD, Wang ZP, Obafemi-Ajayi T, Moore JH.   +8 more
europepmc   +1 more source

Chemically‐Linked Heterostructures of Palladium Nanosheets and 2H‐MoS2

Small, EarlyView.
The photoresponse of MoS2 devices is extended to the near‐infrared region (up to 1700 nm) through chemical connection to Pd nanosheets (PdNS). A maleimide is used for covalent connection to MoS2, and a phenyl bromide moiety for linkage to the PdNS. In the absence of the chemical linker, van der Waals heterostructures show poorer enhancement of the ...
Ramiro Quirós‐Ovies, Pablo Bastante, Simon Hettler, Víctor Vega‐Mayoral, Sergio Aina, Vasileios Balos, Thomas Pucher, Andrés Castellanos‐Gomez, Raul Arenal, Juan Cabanillas‐Gonzalez, Emilio M. Pérez, Jesús Santamaría, Víctor Sebastian   +12 more
wiley   +1 more source

Recording and modeling of pinched hysteresis loops, the fingerprint of a memristor, in neurons. [PDF]

Sci Rep
Pabst O, Schülke C, Balasingham I, Krauss S, Glover JC, Martinsen ØG.   +5 more
europepmc   +1 more source