Results 161 to 170 of about 1,844,829 (280)

K_v7 and K_2P Potassium Channels in Thalamocortical Function and Their Therapeutic Potential in Childhood Absence Epilepsy. [PDF]

Arch Pharm (Weinheim)
Takhi A, Seebohm G, Budde T, Lüttjohann A.   +3 more
europepmc   +1 more source

Assembly of Voltage-gated Potassium Channels [PDF]

Journal of Biological Chemistry, 1995
Jia Xu, Weifeng Yu, Yuh Nung Jan, Lily Yeh Jan, Min Li   +4 more
openaire   +1 more source

β‐Hydroxybutyrate reduces neuronal excitability via GIRK channels

Epilepsia, EarlyView.
β‐Hydroxybutyrate decreases neuronal excitability by activating GIRK channels through HCAR2 signaling, providing a cellular mechanism that may contribute to the antiseizure effects of the ketogenic diet. Abstract Objective The ketogenic diet is used to treat drug‐resistant epilepsy, yet the molecular mechanisms coupling metabolic state to seizure ...
Soudabeh Naderi, John Williamson, Jhanvi Patel, Samikksha Kumar, Huayu Sun, Lucy Dang Nguyen, Katarzyna Rękawek, Ifrah Zawar, Jaideep Kapur   +8 more
wiley   +1 more source

Correction: Evolution, hibernation, and inactivation of voltage-gated Na channels. [PDF]

J Gen Physiol
Willis JS.
europepmc   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Ion Channels as Gatekeepers of Fertility: From Uterine Kir7.1 to Sperm CatSper. [PDF]

Physiology (Bethesda)
Niu Q, Lishko PV.
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

The cornea-trigeminal axis: potassium channels as master regulators of ocular surface homeostasis and sensory transduction. [PDF]

Front Cell Dev Biol
Zhang J, Chen X, Ji J, Chen P, Yao J, Liu L, Tang L, Wen X.   +7 more
europepmc   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Utero-placental calcium and magnesium ion channels: A systematic review of obstetric implications of their alterations. [PDF]

Channels (Austin)
Ndinganire G, Niyomugabo AP, Owu DU, Olubiyi MV, Ikwuka DC, Niyodusenga A, Adeniyi MJ, Walle M, Okeke OC, Feyitimi AA, Eze ED, Ime AU, Ani EJ, Jimoh A, Umar AH, Haile DW, Alagbonsi AI, Onaadepo O.   +17 more
europepmc   +1 more source