Optical neuromodulation with IR light allows stimulation of the PNS without the need for physical contact with the target nerve or without requiring any genetic modification. The clinical translation of this technique will pave the way to the development of neural interfaces for restoring sensory feedback in individuals with limb amputation.
Federica Piccirillo +20 more
wiley +1 more source
Phenytoin Derivatives as Antagonists of AMPA Receptors and Voltage-Gated Sodium Channels: A Structure-Function Study. [PDF]
Zhigulin AS +5 more
europepmc +1 more source
Abstract Background Childhood‐onset hyperkinetic movement disorders occur in a range of genetic conditions. Recently, there has been an increase in recognition of hyperkinetic movement disorders, mainly dystonia, chorea and dyskinesia, with monogenic conditions associated with neurodevelopmental delay (NDD) and also with developmental and epileptic ...
Hugo Morales‐Briceño +6 more
wiley +1 more source
From Marine Peptides to Oncology: The Therapeutic Potential of Conotoxins in Cancer Treatment. [PDF]
Awais S +6 more
europepmc +1 more source
Correction: KV3.1 channel modulation: a systematic review of pharmacological intervention strategies. [PDF]
Frontiers Production Office.
europepmc +1 more source
Cross‐Cohort Evidence Links KCNJ6 rs702859 to Impulsive–Compulsive Phenotypes in Parkinson's Disease
Abstract Background Impulse control disorders (ICDs) and related compulsive behaviors (CBs) are frequent non‐motor complications of Parkinson's disease (PD) with a probable genetic contribution. Objective To investigate whether genetic variants involved in reward and punishment processing are associated with impulsive–compulsive phenotypes in PD ...
Sergio García‐Díaz +21 more
wiley +1 more source
Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi +5 more
wiley +1 more source
New insights into the physiological, pathological and pharmacological roles of voltage‑gated potassium channel Kv10.1 in cancer (Review). [PDF]
Zhen Y +9 more
europepmc +1 more source
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca +7 more
wiley +1 more source
K<sub>v</sub>7 and K<sub>2P</sub> Potassium Channels in Thalamocortical Function and Their Therapeutic Potential in Childhood Absence Epilepsy. [PDF]
Takhi A +3 more
europepmc +1 more source

