Results 191 to 200 of about 1,844,829 (280)

Barium senses subtle pore changes in a voltage-gated K⁺ channel associated with voltage sensor states and regulatory subunits. [PDF]

Sci Adv
Huang L, Daus N, Wang Y, Zhang G, Khier M, Ben-Bassat A, Shi J, Zhao L, Zhang B, Han L, Haitin Y, Attali B, Cui J.   +12 more
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Electro-Mechanical Uncoupling of K_V7.1 Voltage Sensor and Pore by 1,4-Benzodiazepines Is Modulated by Decoration of Position 1. [PDF]

Arch Pharm (Weinheim)
Roßner F, Jepps T, Bentzen BH, Strutz-Seebohm N, Wünsch B, Seebohm G.   +5 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Ionic Homeostasis Failure in Major Depressive Disorder: Ion Channel Mechanisms, Excitation-Inhibition Imbalance, and Precision Therapeutics. [PDF]

Int J Mol Sci
Seo Y.
europepmc   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Emerging Environmental Contaminants Targeting Cardiovascular Ion Channels: Exposure Effects, Underlying Mechanisms, and Implications for Cardiovascular Health Risks. [PDF]

Toxics
Zhan D, Li D, Guo S, Chai X, Cao R, Deng W, Wu K, Li Y, Tsang SY, Cai Z, Qi Z.   +10 more
europepmc   +1 more source

Opportunities for 2D‐Material‐Based Multifunctional Devices and Systems in Bioinspired Neural Networks

Small, EarlyView.
Bio‐inspired computing offers a route to highly energy‐efficient artificial intelligence. The unique physical properties of two‐dimensional (2D) materials can further enhance such computing approaches. This perspective highlights recent developments in 2D materials‐based neuromorphic devices and discusses future opportunities for integrating such novel
Jin Feng Leong, Maheswari Sivan, Jieming Pan, Zihang Fang, Jianan Li, Zefeng Xu, Shi Zhao, Quanzhen Wan, Evgeny Zamburg, Aaron Voon‐Yew Thean   +9 more
wiley   +1 more source

Molecular Mechanisms of Local Anesthetic Toxicity: From Ion Channel Dysregulation to Mitochondrial Dysfunction and Tissue-Specific Injury. [PDF]

Int J Mol Sci
Rijavec B, Salihović M, Mirković T.
europepmc   +1 more source

Impacts of Fluorination at the Ortho‐Position of Carboxy Groups on Tetrakis(biphenyl)ethene‐Based Hydrogen‐Bonded Framework

Small, EarlyView.
This work provides new findings on the effect of fluorination on the substitution of TPE derivatives and the modulation of the structure and fluorescence properties of hydrogen‐bonded organic framework (HOF) of F‐CBPE. ABSTRACT Fluorination of building block molecules is one of the effective engineering approaches to modulate molecular assembly in ...
Takuto Fujii, Mario de la Hoz Tomás, Ryusei Oketani, Boiko Cohen, Ken‐ichi Otake, Kazuki Shiga, Norimitsu Tohnai, Abderrazzak Douhal, Ichiro Hisaki   +8 more
wiley   +1 more source