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Mechanism of Electromechanical Coupling in Voltage-Gated Potassium Channels [PDF]
Frontiers in Pharmacology, 2012 Voltage-gated ion channels play a central role in the generation of action potentials in the nervous system. They are selective for one type of ion - sodium, calcium, or potassium. Voltage-gated ion channels are composed of a central pore that allows ions to pass through the membrane and four peripheral voltage sensing domains that respond to changes ...
Rikard Blunck, Blunck Rikard
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Mechanism of Voltage Gating in Potassium Channels
Science, 2012Open and Shut Case Voltage-sensing domains (VSDs) control the activity of voltage-gated ion channels to regulate the ion flow that underlies nerve conduction. Structural and biophysical studies have provided insight into voltage gating; however, understanding has been hindered by the lack of a crystal structure of a fully closed ...
Morten Ø, Jensen +5 more
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Thermodynamics of a voltage-gated potassium channel
Physical Review EIn order to know how a single potassium channel works in its microscopic niche, a hybrid process about the observables of channel state and voltage is constructed, which comprises the interweaving kinetics of channel gating, voltage decay, and thermal noise. The formula of entropy production rates (i.e., power dissipation) is derived and the stationary
Jia-Zeng Wang +3 more
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The voltage-gated potassium channels and their relatives
Nature, 2002The voltage-gated potassium channels are the prototypical members of a family of membrane signalling proteins. These protein-based machines have pores that pass millions of ions per second across the membrane with astonishing selectivity, and their gates snap open and shut in milliseconds as they sense changes in voltage or ligand concentration.
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Voltage-gated potassium channel antibodies
Neurology, 2016A radioimmunoassay (RIA) to detect antibodies against what was initially believed to be voltage-gated potassium channels (VGKC) in patients with neuromyotonia was established 20 years ago.1 The rationale for this test came from previous RIA assays that detected antibodies against acetylcholine receptors or voltage-gated calcium channels in which the ...
Francesc, Graus, Mark P, Gorman
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Voltage-Gated Potassium Channels in Cell Proliferation
Physiology, 2004It is commonly accepted that cells require K+channels to proliferate. The role(s) of K+channels in the process is, however, poorly understood. Cloning of K+channel genes opened the possibility to approach this problem in a way more independent from pharmacological tools.
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Voltage‐gated Potassium Channel as a Facilitator of Exocytosis
Annals of the New York Academy of Sciences, 2009Voltage‐gated ion channels are well characterized for their function in excitability signals. Accumulating studies, however, have established an ion‐independent function for the major classes of ion channels in cellular signaling. During the last few years we established a novel role for Kv2.1, a voltage‐gated potassium (Kv) channel, classically known ...
Lori, Feinshreiber +3 more
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Enzymatic activation of voltage-gated potassium channels
Nature, 2006Voltage-gated ion channels in excitable nerve, muscle, and endocrine cells generate electric signals in the form of action potentials. However, they are also present in non-excitable eukaryotic cells and prokaryotes, which raises the question of whether voltage-gated channels might be activated by means other than changing the voltage difference ...
Yajamana, Ramu, Yanping, Xu, Zhe, Lu
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