Characterization of five RNA editing sites in Shab potassium channels. [PDF]
Channels (Austin), 2008 RNA editing revises the genetic code at precise locations, creating single base changes in mRNA. These changes can result in altered coding potential and modifications to protein function. Sequence analysis of the Shab potassium channel of Drosophila melanogaster revealed five such RNA editing sites.
Ryan MY, Maloney R, Reenan R, Horn R.
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The Shab family potassium channels are highly enriched at the presynaptic terminals of human neurons. [PDF]
J Biol ChemThe Shab family voltage-gated K+ channels (i.e., Kv2.1, Kv2.2) are widely expressed in mammalian brain and regulate neuronal action-potential firing. In addition to their canonical functions, the Kv2 proteins help establish direct attachments between plasma membrane and endoplasmic reticulum (ER), also known as ER-plasma membrane junctions.
Benner O +4 more
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K⁺-dependent selectivity and external Ca²⁺ block of Shab K⁺ channels. [PDF]
PLoS ONE, 2015 Potassium channels allow the selective flux of K⁺ excluding the smaller, and more abundant in the extracellular solution, Na⁺ ions. Here we show that Shab is a typical K⁺ channel that excludes Na⁺ under bi-ionic, Na(o)/K(i) or Na(o)/Rb(i), conditions ...
Elisa Carrillo +3 more
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Spider venom peptides with unique fold selectively block Shaker-type potassium channels [PDF]
Cellular and Molecular Life SciencesNatural toxins are highly effective at targeting ion channels with high selectivity and potency. To date, all identified spider venom peptide toxins that modulate voltage-gated potassium (KV) channels inhibit Shab (KV2) or Shal-related isoforms (KV4) by ...
Alexey I. Kuzmenkov +11 more
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Distinct Frequency-Dependent Regulation of Nerve Terminal Excitability and Synaptic Transmission by IA and IK Potassium Channels Revealed by Drosophila Shaker and Shab Mutations [PDF]
Journal of Neuroscience, 2006 Regulation of synaptic efficacy by nerve terminal excitability has not been extensively studied. We performed genetic and pharmacological dissections for presynaptic actions of K+ channels in Drosophila neuromuscular transmission by using electrophysiological and optical imaging techniques.
Atsushi, Ueda, Chun-Fang, Wu
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Conductance stability and Na+ interaction with Shab K+ channels under low K+ conditions. [PDF]
Channels (Austin), 2021 Gómez-Lagunas F +2 more
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Voltage Sensitivity and Gating Charge in Shaker and Shab Family Potassium Channels [PDF]
The Journal of General Physiology, 1999 The members of the voltage-dependent potassium channel family subserve a variety of functions and are expected to have voltage sensors with different sensitivities. The Shaker channel of Drosophila, which underlies a transient potassium current, has a high voltage sensitivity that is conferred by a large gating charge movement, ∼13 elementary charges ...
L D, Islas, F J, Sigworth
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Temporal Regulation ofShaker- andShab-Like Potassium Channel Gene Expression in Single Embryonic Spinal Neurons during K+Current Development [PDF]
The Journal of Neuroscience, 1996 A developmental increase in density of delayed rectifier potassium current (IKv) in embryonicXenopusspinal neurons shortens action potential durations and limits calcium influx governing neuronal differentiation. Although previous work demonstrates that maturation ofIKvdepends on general mRNA synthesis, it is not known whether increases in K+channel ...
D, Gurantz, A B, Ribera, N C, Spitzer
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Genomics, 1995 A human delayed rectifier K+ channel gene has been localized to the long arm of human chromosome 20q13.2 by fluorescence in situ hybridization of genomic P1 clones from this locus. A polymorphic (GA) microsatellite repeat was identified in one of the P1 clones. The new SSR marker (D20S436) was genotyped in four CEPH pedigrees.
R, Melis +7 more
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Potassium-dependent stability of Shab potassium channels
, 2016 Potassium modulates the pore conformation in Shab potassium ...
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