Results 11 to 20 of about 855 (114)

Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells. [PDF]

J Physiol
Abstract figure legend: We tested the effects of expressing the bacterial voltage‐gated sodium channel NaChBac in the Kenyon cells of the Drosophila memory centre, the mushroom body. NaChBac expression decreases expression of endogenous voltage‐gated sodium channels (left), reduces action potential firing (upper) and prevents learning (lower). However,
Greenin-Whitehead K, Rozenfeld E, Moreno-Sanchez A, Tan MW, Kullu K, Ausborn J, Parnas M, Lin AC.   +7 more
europepmc   +2 more sources

Dissecting the role of toll‐like receptor 7 in pancreatic cancer

Cancer Medicine, Volume 12, Issue 7, Page 8542-8556, April 2023., 2023
There are conflicting reports regarding the expression pattern and function of TLR7 in pancreatic cancer. A new study shows that high TLR7 expression correlates with shorter overall survival and its inhibition results in reduced cell viability. Abstract Background Toll‐like receptors (TLRs) are gaining attention for their potential to influence tumor ...
Maren Stark, Marina Nicolai, Marina Tatura, Corinna U. Keber, Andreas Kaufmann, Ho‐Ryun Chung, Emily P. Slater, Christopher Heeschen, Rita T. Lawlor, Aldo Scarpa, Detlef K. Bartsch, Thomas M. Gress, Stefan Bauer, Malte Buchholz   +13 more
wiley   +1 more source

Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on sustainable dietary and physical activity recommendations for the Spanish population

Food Risk Assess Europe, Volume 1, Issue 1, March 2023., 2023
Abstract Dietary recommendations are developed from the best available scientific evidence on the effect of nutrients and food on health. These recommendations take into account that the effect of food depends not only on its nutritional content but also on the matrix in which is ingested, the alterations during the culinary process, the presence of ...
Esther López García, Irene Bretón Lesmes, Araceli Díaz Perales, Victoria Moreno Arribas, María del Puy Portillo Baquedano, Ana María Rivas Velasco, Ujué Fresán Salvo, Laura Tejedor Romero, Francisco Bartolomé Ortega Porcel, Susana Aznar Laín, Enrique Lizalde Gil, María Ángeles Carlos Chillerón   +11 more
wiley   +1 more source

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

Modulation of potassium channels by transmembrane auxiliary subunits via voltage-sensing domains. [PDF]

Physiol Rep
Abstract Voltage‐gated K+ (KV) and Ca2+‐activated K+ (KCa) channels are essential proteins for membrane repolarization in excitable cells. They also play important physiological roles in non‐excitable cells. Their diverse physiological functions are in part the result of their auxiliary subunits.
Nakajo K, Kasuya G.
europepmc   +2 more sources

Pentameric assembly of the Kv2.1 tetramerization domain

Acta Crystallographica Section D, Volume 78, Issue 6, Page 792-802, June 2022., 2022
The selective assembly of Kv subunits into one of four subfamilies of tetrameric, voltage‐gated potassium channels is mediated by the T1 tetramerization domain. Here, it was found that unlike the other Kv T1 domains that have been studied to date, the human Kv2.1 T1 domain forms a pentamer, and that zinc binding and electrostatics contribute to the ...
Zhen Xu, Saif Khan, Nicholas J. Schnicker, Sheila Baker   +3 more
wiley   +1 more source

Cyclic nucleotide‐dependent ionic currents in olfactory receptor neurons of the hawkmoth Manduca sexta suggest pull–push sensitivity modulation

European Journal of Neuroscience, Volume 54, Issue 3, Page 4804-4826, August 2021., 2021
Olfactory receptor neurons express circadian rhythms in intracellular cAMP levels peaking during the moth's activity phase at night (black bar; dark shade) while cAMP and cGMP are antagonistically controlled via circadian changes in Ca2+ levels. Thus, for intermittent odour responses, different sets of second messenger‐dependent ion channels are ...
Jan Dolzer, Katrin Schröder, Monika Stengl   +2 more
wiley   +1 more source

The homeobox transcription factor Even-skipped regulates acquisition of electrical properties in Drosophila neurons [PDF]

, 2006
Background While developmental processes such as axon pathfinding and synapse formation have been characterized in detail, comparatively less is known of the intrinsic developmental mechanisms that regulate transcription of ion channel genes in ...
Southall Tony D, Southall, Tony D., Baines, Richard A., Richard A Baines, Southall, TD, Pym, Edward C.G., Brand, Andrea H., Tony D Southall, Baines, RA; id_orcid, Mee Christopher J, Pym Edward CG, Brand, AH, Brand Andrea H, Mee, CJ, Edward CG Pym, Mee, Christopher J., Pym, ECG, Baines Richard A, Christopher J Mee, Andrea H Brand   +19 more
core   +1 more source

Physiological Significance of Ion Transporters and Channels in the Stomach and Pathophysiological Relevance in Gastric Cancer

Evidence-Based Complementary and Alternative Medicine, Volume 2020, Issue 1, 2020., 2020
Gastric cancer (GC) is a highly invasive and fatal malignant disease that accounts for 5.7% of new global cancer cases and is the third leading cause of cancer‐related death. Acid/base homeostasis is critical for organisms because protein and enzyme function, cellular structure, and plasma membrane permeability change with pH.
Dumin Yuan, Zhiyuan Ma, Biguang Tuo, Taolang Li, Xuemei Liu, Ho Lin   +5 more
wiley   +1 more source

Multiple Shaker Potassium Channels in a Primitive Metazoan

, 1995
Voltage-gated potassium channels are critical elements in providing functional diversity in nervous systems. The diversity of voltage-gated K+ channels in modern triploblastic metazoans (such as mollusks, arthropods and vettebrates) is provided primarily
Salkoff, L., Jegla, T., Grigoriev, N., Spencer, A.N., Gallin, W.J.   +4 more
core   +2 more sources