Results 231 to 240 of about 1,936,204 (283)

A guide to host genetic determinants of female microbiome composition across distinct anatomical niches

The FEBS Journal, EarlyView.
Host genetic variation in immune regulation and cell signalling genes was associated with microbiome composition across vaginal, gut, oral and skin sites, while associations involving metabolic function, epithelial barrier integrity and hormonal processes were more site‐specific. Overall, our findings indicate that host genetic variation contributes to
Isabella Margaret Davidson, Elham Nikbakht, Hayley O'Neill, Larisa Margaret Haupt, Paul Joseph Dunn   +4 more
wiley   +1 more source

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

MicroRNA-sensing plasmid system for dynamic control of functional ion channel expression. [PDF]

Mol Ther Nucleic Acids
Geuter J, Austin TT, Corke J, Tian N, Brown J, Schorge S, Morris G.   +6 more
europepmc   +1 more source

HIV‐associated nephropathy: A decade of clinical outcomes, global disparities and emerging promise

HIV Medicine, EarlyView.
Abstract Objective To review the pathogenesis, epidemiology, clinical presentation, management and outcomes of HIV‐associated nephropathy (HIVAN), with emphasis on global disparities, genetic susceptibility (APOL1) and emerging therapeutic and technological advances.
Deepak V. Pathiyil, Nicola Wearne, Brendon Price, Frank Post, Dami A. Collier   +4 more
wiley   +1 more source

Barium senses subtle pore changes in a voltage-gated K⁺ channel associated with voltage sensor states and regulatory subunits. [PDF]

Sci Adv
Huang L, Daus N, Wang Y, Zhang G, Khier M, Ben-Bassat A, Shi J, Zhao L, Zhang B, Han L, Haitin Y, Attali B, Cui J.   +12 more
europepmc   +1 more source

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source

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Mechanism of Voltage Gating in Potassium Channels

Science, 2012
Open and Shut Case Voltage-sensing domains (VSDs) control the activity of voltage-gated ion channels to regulate the ion flow that underlies nerve conduction. Structural and biophysical studies have provided insight into voltage gating; however, understanding has been hindered by the lack of a crystal structure of a fully closed ...
Morten Ø, Jensen, Vishwanath, Jogini, David W, Borhani, Abba E, Leffler, Ron O, Dror, David E, Shaw   +5 more
openaire   +2 more sources

Thermodynamics of a voltage-gated potassium channel

Physical Review E
In order to know how a single potassium channel works in its microscopic niche, a hybrid process about the observables of channel state and voltage is constructed, which comprises the interweaving kinetics of channel gating, voltage decay, and thermal noise. The formula of entropy production rates (i.e., power dissipation) is derived and the stationary
Jia-Zeng Wang, PengKun Hu, YueYing Zheng, YuMei Li   +3 more
openaire   +3 more sources

The voltage-gated potassium channels and their relatives

Nature, 2002
The voltage-gated potassium channels are the prototypical members of a family of membrane signalling proteins. These protein-based machines have pores that pass millions of ions per second across the membrane with astonishing selectivity, and their gates snap open and shut in milliseconds as they sense changes in voltage or ligand concentration.
openaire   +2 more sources