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Voltage‐gated Potassium Channel as a Facilitator of Exocytosis
Annals of the New York Academy of Sciences, 2009Voltage‐gated ion channels are well characterized for their function in excitability signals. Accumulating studies, however, have established an ion‐independent function for the major classes of ion channels in cellular signaling. During the last few years we established a novel role for Kv2.1, a voltage‐gated potassium (Kv) channel, classically known ...
Lori, Feinshreiber +3 more
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Enzymatic activation of voltage-gated potassium channels
Nature, 2006Voltage-gated ion channels in excitable nerve, muscle, and endocrine cells generate electric signals in the form of action potentials. However, they are also present in non-excitable eukaryotic cells and prokaryotes, which raises the question of whether voltage-gated channels might be activated by means other than changing the voltage difference ...
Yajamana, Ramu, Yanping, Xu, Zhe, Lu
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Voltage-gated potassium channel antibodies
Neurology, 2016A radioimmunoassay (RIA) to detect antibodies against what was initially believed to be voltage-gated potassium channels (VGKC) in patients with neuromyotonia was established 20 years ago.1 The rationale for this test came from previous RIA assays that detected antibodies against acetylcholine receptors or voltage-gated calcium channels in which the ...
Francesc, Graus, Mark P, Gorman
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Neuronal trafficking of voltage-gated potassium channels
Molecular and Cellular Neuroscience, 2011The computational ability of CNS neurons depends critically on the specific localization of ion channels in the somatodendritic and axonal membranes. Neuronal dendrites receive synaptic inputs at numerous spines and integrate them in time and space. The integration of synaptic potentials is regulated by voltage-gated potassium (Kv) channels, such as ...
Jensen, Camilla S +2 more
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Animal Toxins Acting on Voltage-Gated Potassium Channels
Current Pharmaceutical Design, 2008Animal venoms are rich natural sources of bioactive compounds, including peptide toxins acting on the various types of ion channels, i.e. K(+), Na(+), Cl(-) and Ca(2+). Among K+ channel-acting toxins, those selective for voltage-gated K(+) (Kv) channels are widely represented and have been isolated from the venoms of numerous animal species, such as ...
Stéphanie, Mouhat +3 more
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Voltage-gated potassium channels
Acta Crystallographica Section A Foundations and Advances, 2023openaire +2 more sources
Voltage-Gated Potassium Channels in the Myocardium
2001The cardiac action potential results from the complex, but precisely controlled, movement of ions across the cell membrane. Although the shape of the action potential is known to vary between different regions of the heart (e.g., sinoatrial node vs. atrial vs. ventricle), the present discussion will focus solely on the ventricular myocardium.
Joanne T. Hulme +4 more
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Pharmacology of Voltage-Gated Potassium Channels
2000Voltage-gated potassium (Kv) channels play an important role in many cellular functions correlated with changes in excitability. Their functions range from the setting of basal levels of membrane potential to shaping action potentials in excitable cells (PAPAZIAN et al. 1987).
O. Pongs, C. Legros
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Ins and outs of cardiac voltage-gated potassium channels
Current Opinion in Pharmacology, 2009Voltage-gated potassium (Kv) channels play an important role in regulating cardiac muscle excitability by controlling action potential duration and frequency. Essential for this activity is proper localization and organization of the cardiac Kv channels in specific microdomains of the plasma membrane.
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