Results 221 to 230 of about 64,601 (257)
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Voltage-gated Potassium Channel Inhibitors
Current Pharmaceutical Design, 1996Forty years have transpired since tetraethylammonium was first used to selectively inhibit the potassiuin conductance in squid axons. Since then, a large body of work has emerged describing inhibitors of voltage-gated potassium currents in a variety of cells.
George P Miljanich
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Animal Toxins Acting on Voltage-Gated Potassium Channels
Current Pharmaceutical Design, 2008Animal venoms are rich natural sources of bioactive compounds, including peptide toxins acting on the various types of ion channels, i.e. K(+), Na(+), Cl(-) and Ca(2+). Among K+ channel-acting toxins, those selective for voltage-gated K(+) (Kv) channels are widely represented and have been isolated from the venoms of numerous animal species, such as ...
Stéphanie, Mouhat +3 more
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Pharmacology of Voltage-Gated Potassium Channels
2000Voltage-gated potassium (Kv) channels play an important role in many cellular functions correlated with changes in excitability. Their functions range from the setting of basal levels of membrane potential to shaping action potentials in excitable cells (PAPAZIAN et al. 1987).
O. Pongs, C. Legros
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Voltage-Gated Potassium Channels
Acta Crystallographica Section A Foundations and Advances, 2023openaire +2 more sources
Voltage-Gated Potassium Channels in the Myocardium
2001The cardiac action potential results from the complex, but precisely controlled, movement of ions across the cell membrane. Although the shape of the action potential is known to vary between different regions of the heart (e.g., sinoatrial node vs. atrial vs. ventricle), the present discussion will focus solely on the ventricular myocardium.
Joanne T. Hulme +4 more
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Ins and outs of cardiac voltage-gated potassium channels
Current Opinion in Pharmacology, 2009Voltage-gated potassium (Kv) channels play an important role in regulating cardiac muscle excitability by controlling action potential duration and frequency. Essential for this activity is proper localization and organization of the cardiac Kv channels in specific microdomains of the plasma membrane.
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Activation of the Voltage‐Gated Potassium Channel by Amphiphilic Glycopeptides
Chemistry – A European JournalAbstractVoltage‐gated ion channels (VGICs) are allosterically modulated by glycosaminoglycan proteoglycans and sialic acid glycans. However, the structural diversity and heterogeneity of these biomolecules pose significant challenges to precisely delineate their underlying structure‐activity relationships. Herein, we demonstrate how heparan sulfate (HS)
Saurabh Anand +5 more
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