Results 171 to 180 of about 171,305 (316)

Special Issue "Ion Channels as a Therapeutic Target: Drug Design and Pharmacological Investigation 2.0. [PDF]

Int J Mol Sci
Guerrini G, Giovannoni MP.
europepmc   +1 more source

Do all voltage-gated potassium channels use MiRPs? [PDF]

, 2001
Abbott, GW, Goldstein, SA, Sesti, F
core  

Voltage-Gated Potassium Channels at the Crossroads of Neuronal Function, Ischemic Tolerance, and Neurodegeneration

Translational Stroke Research, 2014
N. H. Shah, E. Aizenman
semanticscholar   +1 more source

Assembly of Voltage-gated Potassium Channels [PDF]

Journal of Biological Chemistry, 1995
Jia Xu, Weifeng Yu, Yuh Nung Jan, Lily Yeh Jan, Min Li   +4 more
openaire   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Beyond sodium channel blockade: Flavonoid as alternative local anesthetic candidates of lidocaine. [PDF]

Mol Pain
Takeda M, Utugi S, Toyota R, Sashide Y.
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

The molecular basis of KCNH1-related epileptic encephalopathy and the challenge of developing targeted therapeutics. [PDF]

Brain
Sundman AK, Jin S, Vadlamudi L, King GF.
europepmc   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

The Helix Ring Peptide U11 from the Venom of the Ant, Tetramorium bicarinatum, Acts as a Putative Pore-Forming Toxin, Not a New Kv1.3 Channel Blocker. Comment on Boy et al. A New Kv1.3 Channel Blocker from the Venom of the Ant Tetramorium bicarinatum. Toxins 2025, 17, 379. [PDF]

Toxins (Basel)
Peigneur S, Tibery D, Tytgat J.
europepmc   +1 more source