Results 231 to 240 of about 182,239 (338)

Dichloroacetate, a Metabolic Modulator, Prevents and Reverses Chronic Hypoxic Pulmonary Hypertension in Rats: Role of Increased Expression and Activity of Voltage-Gated Potassium Channels

Circulation, 2002
E. Michelakis, M. S. Mcmurtry, Xichen Wu, J. Dyck, R. Moudgil, T. Hopkins, G. Lopaschuk, L. Puttagunta, R. Waite, Stephen L. Archer   +9 more
semanticscholar   +1 more source

Patient outcomes in KCNQ2 developmental and epileptic encephalopathy

Developmental Medicine &Child Neurology, EarlyView.
Abstract The aim of this study was to review and summarize the literature describing clinically observed or caregiver‐reported and patient‐reported KCNQ2 developmental and epileptic encephalopathy (DEE) outcomes. Three online databases and selected congress proceedings were searched (August 2023).
Grant Maclaine, Michele H. Potashman, Deepshikha Pawar, Sugandh Sharma, Katja Rudell, Jason Lerner, Vlad Coric, Anne T. Berg, John Millichap, Gil L'Italien   +9 more
wiley   +1 more source

Impaired excitability of fast-spiking neurons in a novel mouse model of <i>KCNC1</i> epileptic encephalopathy. [PDF]

Elife
Wengert ER, Liebergall SR, Jimenez T, Cheng MA, Markwalter KH, Clatot J, Hong Y, Arias L, Marsh ED, Zhang X, Tsetsenis T, Somarowthu A, Akizu N, Goldberg EM.   +13 more
europepmc   +1 more source

A supramolecular assembly of cone‐specific G‐protein and cryptochrome 4a on lipid bilayer

The FEBS Journal, EarlyView.
Immobilized phospholipid bilayers on a sensor chip surface serve as membrane platform to investigate critical protein–lipid and protein–protein interaction processes by surface plasmon resonance. The putative magnetoreceptor cryptochrome 4a and the myristoylated cone‐specific G‐protein α‐subunit (Gtα) bind with high affinity to immobilized lipid ...
Ümmügülsüm Güzelsoy‐Flügge, Srđan Vujinović, Alexander Scholten, Karl‐Wilhelm Koch   +3 more
wiley   +1 more source

ROS-induced voltage-gated ion channel expression and electrophysiological remodeling in malignant human cells. [PDF]

NPJ Syst Biol Appl
Mohammadiaria M.
europepmc   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source

Expression of voltage-gated potassium channels in human and rhesus pancreatic islets.

Diabetes, 2004
Lizhen Yan, D. Figueroa, C. Austin, Yuan Liu, R. Bugianesi, R. S. Slaughter, G. Kaczorowski, M. Kohler   +7 more
semanticscholar   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Evaluation of a New Riluzole-Based Compound VA945 on Sodium and Potassium Conductances Expressed by SH-SY5Y- Derived Neurons. [PDF]

J Neurochem
Cazzola J, Talpo F, Faravelli G, Donati C, Maramai S, Saletti M, Giuliani G, Paolino M, Cappelli A, Anzini M, Sommi P, Vitali A, Sala A, Trucco A, Biella GR, Spaiardi P.   +15 more
europepmc   +1 more source

Phosphatidylinositol‐4,5‐bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage‐gated potassium channels: a functional homology between voltage‐gated and inward rectifier K+ channels

EMBO Journal, 2003
G. Loussouarn, Kyu-Ho Park, C. Bellocq, I. Baró, F. Charpentier, D. Escande   +5 more
semanticscholar   +1 more source