Results 11 to 20 of about 3,077,235 (395)
Alternative Targets for Modulators of Mitochondrial Potassium Channels
Molecules, 2022 Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of reactive oxygen species (ROS).
Antoni Wrzosek +4 more
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Drunk potassium channels [PDF]
Europace, 2011 We report the case of a 42-year-old woman who was admitted due to alcohol induced dehydration leading to cardiac symptoms. On physical examination severe hypokalaemia and long QT syndrome were apparent. During potassium (K+) supplementation we simultaneously observed QT interval recovery.
Amir M, Nia +3 more
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Hydrogen Sulfide-Induced Vasodilation: The Involvement of Vascular Potassium Channels
Frontiers in Pharmacology, 2022 Hydrogen sulfide (H2S) has been highlighted as an important gasotransmitter in mammals. A growing number of studies have indicated that H2S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis. Alteration in
Xiao-Yu Liu +2 more
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FEBS Letters, 2003 The atomic structures of K+ channels have added a new dimension to our understanding of K+ channel function. I will briefly review how structures have influenced our views on ion conduction, gating of the pore, and voltage sensing.
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Potassium channels: Novel targets for tumor diagnosis and chemoresistance
Frontiers in Oncology, 2023 In recent years, the role of potassium channels in tumors has been intensively studied. Potassium channel proteins are widely involved in various physiological and pathological processes of cells.
Meizeng Li +4 more
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The role of axonal voltage-gated potassium channels in tDCS
Brain Stimulation, 2022 Background: Transcranial direct current stimulation (tDCS) is a non-invasive sub-threshold stimulation, widely accepted for its amelioration of distinct neuropsychiatric disorders.
Sreerag Othayoth Vasu, Hanoch Kaphzan
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Potassium channel regulation [PDF]
EMBO reports, 2003 The sulphonylurea receptor (SUR) is a member of the ATP-binding cassette (ABC) family of membrane proteins. It functions as the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which comprises SUR and Kir6.x proteins. Here, we review data demonstrating functional differences between the two nucleotide binding domains (NBDs) of SUR1. In
Campbell, J, Sansom, MS, Ashcroft, F
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ATP-Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles.
Comprehensive Physiology, 2018 ATP sensitive potassium channels (KATP ) are so named because they open as cellular ATP levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to membrane excitability.
A. Tinker +3 more
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Potassium Ion Channels in Glioma: From Basic Knowledge into Therapeutic Applications
Membranes, 2023 Ion channels, specifically those controlling the flux of potassium across cell membranes, have recently been shown to exhibit an important role in the pathophysiology of glioma, the most common primary central nervous system tumor with a poor prognosis ...
Samar Younes +4 more
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Potassium Channel Mechanics [PDF]
Neuron, 2001 What is the moving part that switches an ion channel's current on and off? In this issue of Neuron del Camino and Yellen (2001) exploit scanning cysteine mutagenesis and sulfhydryl reagents to show that the intracellular end of the S6 helices forms a mechanical gate for the Shaker potassium channel.
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