Results 11 to 20 of about 401,972 (377)

Role of Kv1 potassium channels in regulating dopamine release and presynaptic D2 receptor function. [PDF]

PLoS ONE, 2011
Dopamine (DA) release in the CNS is critical for motor control and motivated behaviors. Dysfunction of its regulation is thought to be implicated in drug abuse and in diseases such as schizophrenia and Parkinson's.
Philippe Martel, Damiana Leo, Stephanie Fulton, Maxime Bérard, Louis-Eric Trudeau   +4 more
doaj   +5 more sources

Potassium channel‐mediated NO‐induced vasodilation during maturation: Dominance of Kv7 channels [PDF]

FASEB BioAdvances
Maturation represents a process characterized by adaptive changes, particularly in the circulatory system. However, it is not known whether, in neonates, potassium channels contribute to NO‐induced vasorelaxation at all and, if so, which potassium ...
Anastasia A. Shvetsova, Dina K. Gaynullina, Peter Winkler, Paulus Wohlfart, Rudolf Schubert   +4 more
doaj   +2 more sources

Effect of channel block on the spiking activity of excitable membranes in a stochastic Hodgkin-Huxley model [PDF]

PHYSICAL BIOLOGY 1, pp. 61-66 (2004), 2006
The influence of intrinsic channel noise on the spontaneous spiking activity of poisoned excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model. Internal noise stemming from the stochastic dynamics of individual ion channels is known to affect the collective properties of the whole ion channel cluster ...
Chow C C, Clay J R, DeFelice L J, Fox R F, G Schmid, Gammaitoni L, Goldman M S, Hille B, Hodgkin A L, Hänggi P, Hänggi P, I Goychuk, Lecar H, LeMasson G, P Hänggi, Press W H, Skaugen E, Strassberg A F   +17 more
arxiv   +5 more sources

Major Channels Involved In Neuropsychiatric Disorders And Therapeutic Perspectives [PDF]

Frontiers in Genetics, 2013
Voltage-gated ion channels are important mediators of physiological functions in the central nervous system. The cyclic activation of these channels influences neurotransmitter release, neuron excitability, gene transcription and plasticity, providing ...
Paola eImbrici, Diana eConte Camerino, Domenico eTricarico   +2 more
doaj   +4 more sources

Potassium channels: Novel targets for tumor diagnosis and chemoresistance

Frontiers in Oncology, 2023
In recent years, the role of potassium channels in tumors has been intensively studied. Potassium channel proteins are widely involved in various physiological and pathological processes of cells.
Meizeng Li, Peijie Tian, Qing Zhao, Xialin Ma, Yunxiang Zhang   +4 more
doaj   +1 more source

Drunk potassium channels [PDF]

Europace, 2011
We report the case of a 42-year-old woman who was admitted due to alcohol induced dehydration leading to cardiac symptoms. On physical examination severe hypokalaemia and long QT syndrome were apparent. During potassium (K+) supplementation we simultaneously observed QT interval recovery.
Nia, Amir M., Gassanov, Natig, Ortega, Marcos, Er, Fikret   +3 more
openaire   +3 more sources

When Is a Potassium Channel Not a Potassium Channel?

Function, 2022
AbstractEver since they were first observed in Purkinje fibers of the heart, funny channels have had close connections to potassium channels. Indeed, funny channels were initially thought to produce a potassium current in the heart called IK2. However, funny channels are completely unlike potassium channels in ways that make their contributions to the ...
openaire   +2 more sources

Potassium Channels in Epilepsy [PDF]

Cold Spring Harbor Perspectives in Medicine, 2016
This review attempts to give a concise and up-to-date overview on the role of potassium channels in epilepsies. Their role can be defined from a genetic perspective, focusing on variants and de novo mutations identified in genetic studies or animal models with targeted, specific mutations in genes coding for a member of the large potassium channel ...
Jakob Wolfart, Rüdiger Köhling
openaire   +2 more sources

The neuroglial potassium cycle during neurotransmission: role of Kir4.1 channels. [PDF]

PLoS Computational Biology, 2015
Neuronal excitability relies on inward sodium and outward potassium fluxes during action potentials. To prevent neuronal hyperexcitability, potassium ions have to be taken up quickly.
Jérémie Sibille, Khanh Dao Duc, David Holcman, Nathalie Rouach   +3 more
doaj   +1 more source

Potassium Ion Channels in Glioma: From Basic Knowledge into Therapeutic Applications

Membranes, 2023
Ion channels, specifically those controlling the flux of potassium across cell membranes, have recently been shown to exhibit an important role in the pathophysiology of glioma, the most common primary central nervous system tumor with a poor prognosis ...
Samar Younes, Nisreen Mourad, Mohamed Salla, Mohamad Rahal, Dalal Hammoudi Halat   +4 more
doaj   +1 more source