Results 21 to 30 of about 3,077,235 (395)

Role of Kv1 potassium channels in regulating dopamine release and presynaptic D2 receptor function. [PDF]

open access: yesPLoS ONE, 2011
Dopamine (DA) release in the CNS is critical for motor control and motivated behaviors. Dysfunction of its regulation is thought to be implicated in drug abuse and in diseases such as schizophrenia and Parkinson's.
Philippe Martel   +4 more
doaj   +1 more source

Distinct Distribution Patterns of Potassium Channel Sub-Units in Somato-Dendritic Compartments of Neurons of the Medial Superior Olive

open access: yesFrontiers in Cellular Neuroscience, 2019
Coincidence detector neurons of the medial superior olive (MSO) are sensitive to interaural time differences in the range of a few tens of microseconds. The biophysical basis for this remarkable acuity is a short integration time constant of the membrane,
Alisha L. Nabel   +9 more
doaj   +1 more source

MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain

open access: yesNature Communications, 2017
miR-17-92 is a microRNA cluster with six distinct members. Here, we show that the miR-17-92 cluster and its individual members modulate chronic neuropathic pain.
A. Sakai   +7 more
semanticscholar   +1 more source

The Natural Flavone Acacetin Blocks Small Conductance Ca2+-Activated K+ Channels Stably Expressed in HEK 293 Cells

open access: yesFrontiers in Pharmacology, 2017
The natural flavone acacetin inhibits several voltage-gated potassium currents in atrial myocytes, and has anti-atrial fibrillation (AF) effect in experimental AF models.
Kui-Hao Chen   +9 more
doaj   +1 more source

Gas Signaling Molecules and Mitochondrial Potassium Channels

open access: yesInternational Journal of Molecular Sciences, 2018
Recently, gaseous signaling molecules, such as carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H2S), which were previously considered to be highly toxic, have been of increasing interest due to their beneficial effects at low ...
A. Walewska, A. Szewczyk, P. Koprowski
semanticscholar   +1 more source

Human sperm ion channel (dys)function:implications for fertilization [PDF]

open access: yes, 2019
BACKGROUND: Intensive research on sperm ion channels has identified members of several ion channel families in both mouse and human sperm. Gene knock-out studies have unequivocally demonstrated the importance of the calcium and potassium conductances in ...
Barratt, Christopher L. R.   +3 more
core   +4 more sources

The Role of Potassium Channels in Arabidopsis thaliana Long Distance Electrical Signalling: AKT2 Modulates Tissue Excitability While GORK Shapes Action Potentials

open access: yesInternational Journal of Molecular Sciences, 2018
Fast responses to an external threat depend on the rapid transmission of signals through a plant. Action potentials (APs) are proposed as such signals.
T. Cuin, I. Dreyer, Erwan Michard
semanticscholar   +1 more source

Routes for Potassium Ions across Mitochondrial Membranes: A Biophysical Point of View with Special Focus on the ATP-Sensitive K+ Channel

open access: yesBiomolecules, 2021
Potassium ions can cross both the outer and inner mitochondrial membranes by means of multiple routes. A few potassium-permeable ion channels exist in the outer membrane, while in the inner membrane, a multitude of different potassium-selective and ...
Yevheniia Kravenska   +2 more
doaj   +1 more source

Potassium channels in C. elegans [PDF]

open access: yes, 2005
Ion channels are the "transistors" (electronic switches) of the brain that generate and propagate electrical signals in the aqueous environment of the brain and nervous system. Potassium channels are particularly important because, not only do they shape
Baban, Beravan   +6 more
core   +2 more sources

Central cavity dehydration as a gating mechanism of potassium channels

open access: yesNature Communications, 2023
The hydrophobic gating model, in which ion permeation is inhibited by the hydrophobicity, rather than a physical occlusion of the nanopore, functions in various ion channels including potassium channels.
Ruo-Xu Gu, Bert L. de Groot
doaj   +1 more source

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