Results 21 to 30 of about 401,972 (377)

Potassium channels [PDF]

FEBS Letters, 2003
The atomic structures of K+ channels have added a new dimension to our understanding of K+ channel function. I will briefly review how structures have influenced our views on ion conduction, gating of the pore, and voltage sensing.
openaire   +2 more sources

Segment-specific expression of 2P domain potassium channel genes in human nephron. [PDF]

, 2004
BackgroundThe 2P domain potassium (K2P) channels are a recently discovered ion channel superfamily. Structurally, K2P channels are distinguished by the presence of two pore forming loops within one channel subunit. Functionally, they are characterized by
Bockenhauer, Detlef, Goldstein, Steve AN, Levy, Daniel I, Velazquez, Heino   +3 more
core   +1 more source

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. [PDF]

, 1999
A novel potassium channel gene has been cloned, characterized, and associated with cardiac arrhythmia. The gene encodes MinK-related peptide 1 (MiRP1), a small integral membrane subunit that assembles with HERG, a pore-forming protein, to alter its ...
Antzelevitch, Blumenthal, Busch, Busch, Carmeliet, Carmeliet, Chen, Curran, Daleau, Drici, Duggal, Federico Sesti, Geoffrey W Abbott, Goldstein, Ho, Ho, Howarth, Igor Splawski, Kaczmarek, Katherine W Timothy, Lee, Lees-Miller, Liu, London, Makkar, Marianne E Buck, Mark T Keating, McDonald, Michael H Lehmann, Roden, Roden, Sanguinetti, Sanguinetti, Sanguinetti, Sanguinetti, Scamps, Schulze-Bahr, Sesti, Shibasaki, Smith, Snyders, Spector, Spector, Splawski, Splawski, Steve A.N Goldstein, Tai, Tai, Takumi, Takumi, Trudeau, Tyson, Veldkamp, Vetter, Wang, Wang, Wang, Wang, Wollnik, Yang, Yang, Yang, Yang, Zhou, Zou   +64 more
core   +1 more source

Potassium Channel Mechanics [PDF]

Neuron, 2001
What is the moving part that switches an ion channel's current on and off? In this issue of Neuron del Camino and Yellen (2001) exploit scanning cysteine mutagenesis and sulfhydryl reagents to show that the intracellular end of the S6 helices forms a mechanical gate for the Shaker potassium channel.
openaire   +3 more sources

Distinct Distribution Patterns of Potassium Channel Sub-Units in Somato-Dendritic Compartments of Neurons of the Medial Superior Olive

Frontiers in Cellular Neuroscience, 2019
Coincidence detector neurons of the medial superior olive (MSO) are sensitive to interaural time differences in the range of a few tens of microseconds. The biophysical basis for this remarkable acuity is a short integration time constant of the membrane,
Alisha L. Nabel, Alisha L. Nabel, Alexander R. Callan, Alexander R. Callan, Sarah A. Gleiss, Sarah A. Gleiss, Nikolaos Kladisios, Christian Leibold, Felix Felmy, Felix Felmy   +9 more
doaj   +1 more source

Routes for Potassium Ions across Mitochondrial Membranes: A Biophysical Point of View with Special Focus on the ATP-Sensitive K⁺ Channel

Biomolecules, 2021
Potassium ions can cross both the outer and inner mitochondrial membranes by means of multiple routes. A few potassium-permeable ion channels exist in the outer membrane, while in the inner membrane, a multitude of different potassium-selective and ...
Yevheniia Kravenska, Vanessa Checchetto, Ildiko Szabo   +2 more
doaj   +1 more source

The Natural Flavone Acacetin Blocks Small Conductance Ca2+-Activated K+ Channels Stably Expressed in HEK 293 Cells

Frontiers in Pharmacology, 2017
The natural flavone acacetin inhibits several voltage-gated potassium currents in atrial myocytes, and has anti-atrial fibrillation (AF) effect in experimental AF models.
Kui-Hao Chen, Kui-Hao Chen, Hui Liu, Hui Liu, Hai-Ying Sun, Man-Wen Jin, Guo-Sheng Xiao, Yan Wang, Gui-Rong Li, Gui-Rong Li   +9 more
doaj   +1 more source

Kv7 and Kv11 channels in myometrial regulation. [PDF]

, 2013
Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Iain A. Greenwood, Rachel M. Tribe, Selyanko AA, Taggart MJ   +3 more
core   +2 more sources

Central cavity dehydration as a gating mechanism of potassium channels

Nature Communications, 2023
The hydrophobic gating model, in which ion permeation is inhibited by the hydrophobicity, rather than a physical occlusion of the nanopore, functions in various ion channels including potassium channels.
Ruo-Xu Gu, Bert L. de Groot
doaj   +1 more source

Subunit composition of minK potassium channels. [PDF]

, 1995
Expression of minK protein in Xenopus oocytes induces a slowly activating, voltage-dependent, potassium-selective current. Point mutations in minK that alter current gating kinetics, ion selectivity, pharmacology, and response to protein kinase C all ...
Goldstein, SA, Wang, KW
core   +1 more source