Results 31 to 40 of about 31,022 (291)
Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins
Frontiers in Immunology, 2021 Poxviruses have evolved a variety of innate immunity evasion mechanisms, some of which involve poxvirus-encoded E3 ubiquitin ligases and adaptor proteins.
Haoran Cui +7 more
doaj +1 more source
Archives of Virology, 2021 A novel poxvirus was discovered in Crocodilurus amazonicus (Teiidae) presenting with a debilitating skin disease. The generated first genome sequence of a reptilian poxvirus revealed the closest phylogenetic relationship to avipoxviruses, highlighting ...
Kerstin Seitz +13 more
semanticscholar +1 more source
Viruses, 2021 During 2019, five carcasses of juvenile Egyptian fruit bats (Rousettus aegyptiacus) were submitted to the Kimron Veterinary Institute. These bats exhibited typical poxvirus like lesion plaques of different sizes on the skin, abdomen and the ventral side ...
Dan David +5 more
doaj +1 more source
Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
Nature Communications, 2020 Modified Vaccinia Ankara (MVA) is a highly attenuated poxvirus vector that is widely used to develop vaccines for infectious diseases and cancer. We demonstrate the construction of a vaccine platform based on a unique three-plasmid system to efficiently ...
F. Chiuppesi +19 more
semanticscholar +1 more source
Microbiological Reviews, 1991 Poxviruses are a highly successful family of pathogens, with variola virus, the causative agent of smallpox, being the most notable member. Poxviruses are unique among animal viruses in several respects. First, owing to the cytoplasmic site of virus replication, the virus encodes many enzymes required either for macromolecular precursor pool regulation
R M, Buller, G J, Palumbo
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T helper 1 effector memory CD4+ T cells protect the skin from poxvirus infection
Cell Reports, 2023 Summary: Poxvirus infections of the skin are a recent emerging public health concern, yet the mechanisms that mediate protective immunity against these viral infections remain largely unknown.
Jake C. Harbour +10 more
doaj +1 more source
Nature Reviews Microbiology, 2005 Despite the success of the WHO-led smallpox eradication programme a quarter of a century ago, there remains considerable fear that variola virus, or other related pathogenic poxviruses such as monkeypox, could re-emerge and spread disease in the human population.
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The Genome of Yoka Poxvirus [PDF]
Journal of Virology, 2011 ABSTRACT Yoka poxvirus was isolated almost four decades ago from a mosquito pool in the Central African Republic. Its classification as a poxvirus is based solely upon the morphology of virions visualized by electron microscopy. Here we describe sequencing of the Yoka poxvirus genome using a combination of Roche/454 and Illumina ...
Guoyan, Zhao +7 more
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Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]
, 2011 VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward +1 more
core +1 more source
Annals of Internal Medicine, 2020 Background Triplex vaccine was developed to enhance cytomegalovirus (CMV)-specific T cells and prevent CMV reactivation early after hematopoietic stem cell transplant (HCT). Objective To determine the safety and efficacy of Triplex.
Ibrahim Aldoss +18 more
semanticscholar +1 more source