Results 31 to 40 of about 14,236 (163)

Laboratory Infection of Novel Akhmeta Virus in CAST/EiJ Mice

open access: yesViruses, 2020
Akhmeta virus is a zoonotic Orthopoxvirus first identified in 2013 in the country of Georgia. Subsequent ecological investigations in Georgia have found evidence that this virus is widespread in its geographic distribution within the country and in its ...
Clint N. Morgan   +10 more
doaj   +1 more source

Poxvirus under the eyes of electron microscope

open access: yesApplied Microscopy, 2022
Zoonotic poxvirus infections pose significant threat to human health as we have witnessed recent spread of monkeypox. Therefore, insights into molecular mechanism behind poxvirus replication cycle are needed for the development of efficient antiviral ...
Jaekyung Hyun
doaj   +1 more source

Myxoma virus lacking the host range determinant M062 stimulates cGAS-dependent type 1 interferon response and unique transcriptomic changes in human monocytes/macrophages.

open access: yesPLoS Pathogens, 2022
The evolutionarily successful poxviruses possess effective and diverse strategies to circumvent or overcome host defense mechanisms. Poxviruses encode many immunoregulatory proteins to evade host immunity to establish a productive infection and have ...
Steven J Conrad   +7 more
doaj   +1 more source

Identification of Vaccinia Virus Inhibitors and Cellular Functions Necessary for Efficient Viral Replication by Screening Bioactives and FDA-Approved Drugs

open access: yesVaccines, 2020
Four decades after the eradication of smallpox, poxviruses continue to threaten the health of humans and other animals. Vaccinia virus (VACV) was used as the vaccine that successfully eradicated smallpox and is a prototypic member of the poxvirus family.
Chen Peng   +7 more
doaj   +1 more source

Strategies and Patterns of Codon Bias in Molluscum Contagiosum Virus

open access: yesPathogens, 2021
Trends associated with codon usage in molluscum contagiosum virus (MCV) and factors governing the evolution of codon usage have not been investigated so far.
Rahul Raveendran Nair   +4 more
doaj   +1 more source

Viral skin diseases in odontocete cetaceans: gross, histopathological, and molecular characterization of selected pathogens

open access: yesFrontiers in Veterinary Science, 2023
Fifty-five skin lesions from 31 stranded cetaceans along the Canary coasts (2011–2021) were submitted to macroscopic, histological, and molecular analyses to confirm infection by cetacean poxvirus, herpesvirus and cetacean morbillivirus.
Simone Segura-Göthlin   +7 more
doaj   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi   +6 more
wiley   +1 more source

Cowpox virus: What’s in a Name?

open access: yesViruses, 2017
Traditionally, virus taxonomy relied on phenotypic properties; however, a sequence-based virus taxonomy has become essential since the recent requirement of a species to exhibit monophyly.
Matthew R. Mauldin   +6 more
doaj   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

open access: yesVIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai   +11 more
wiley   +1 more source

Dual Use Research of Concern—The Necessity of Global Bioethics Engagement

open access: yesBioethics, EarlyView.
ABSTRACT Dual use research of concern (DURC) refers to research conducted for legitimate scientific purposes that could also be misused to pose a significant threat to public health and safety, agricultural crops and other plants, animals, the environment, or national security.
Daniel J. Hurst, Christopher A. Bobier
wiley   +1 more source

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