Results 31 to 40 of about 55,976 (264)
Frontiers in Cardiovascular Medicine, 2022 Protein phosphatase 2A (PP2A), a crucial serine/threonine phosphatase, has recently been reported to play an important role in cardiovascular disease.
Rui Li +8 more
doaj +1 more source
Hyperglycemia triggers HIPK2 protein degradation [PDF]
, 2016 Homeodomain interacting protein kinase-2 (HIPK2) is an evolutionary conserved kinase that modulates several key molecular pathways to restrain tumor growth and induce p53-depending apoptotic cell-death in response to anticancer therapies. HIPK2 silencing
Baldari, Silvia +6 more
core +2 more sources
An axonemal PP2A B‐subunit is required for PP2A localization and flagellar motility [PDF]
Cytoskeleton, 2011 AbstractAnalysis of Chlamydomonas axonemes revealed that the protein phosphatase, PP2A, is localized to the outer doublet microtubules and is implicated in regulation of dynein‐driven motility. We tested the hypothesis that PP2A is localized to the axoneme by a specialized, highly conserved 55‐kDa B‐type subunit identified in the Chlamydomonas ...
Candice A, Elam +7 more
openaire +2 more sources
IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]
, 2014 The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S +19 more
core +1 more source
Genetic Variant of PP2A Subunit Gene Confers an Increased Risk of Primary Liver Cancer in Chinese
Pharmacogenomics and Personalized Medicine, 2021 Youxin Wang,1,* Qiuyue Huang,1,* Xinglei Huang,1 Huiliu Zhao,2 Bin Guan,1 Kechen Ban,3 Xuefeng Zhu,1 Zhixing Ma,1 Yanmei Tang,1 Zhaohui Su,1 Qingqing Nong1 1Department of Environmental Health, School of Public Health, Guangxi Medical University ...
Wang Y +10 more
doaj
Journal of Pharmacological Sciences, 2022 Studies have shown that inhibition of PI3K/AKT signaling is a key strategy for the treatment of tyrosine kinase inhibitor resistance in non-small cell lung cancer (NSCLC).
Yu Zhang +6 more
doaj +1 more source
Cryptococcus neoformans employs both PP1 and PP2A phosphatases to silence the spindle checkpoint
Suresh AP +5 more
europepmc +2 more sources
Cell Cycle, 2016 Meiosis is a specialized type of cell division in which one round of DNA replication is followed by 2 consecutive rounds of chromosome segregation.
Xiumin Yan, Xueliang Zhu
openaire +1 more source
The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. [PDF]
, 2017 Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein ...
Benjamin, Daniel I +8 more
core +1 more source
Journal of Experimental & Clinical Cancer Research, 2018 Background JS-K is a nitric oxide (NO) donor and could generate intracellularly high levels of NO. The study explores PP2A as a tumor suppressor is a major determinant mediating JS-K-caused apoptosis in human hepatocellular carcinoma (HCC) cells. Methods
Ling Liu +4 more
doaj +1 more source