Results 51 to 60 of about 55,976 (264)

Protein phosphatase 2A dysfunction in Alzheimer’s disease

Frontiers in Molecular Neuroscience, 2014
Protein Phosphatase 2A (PP2A) is a large family of enzymes that account for the majority of brain Ser/Thr phosphatase activity. While PP2A enzymes collectively modulate most cellular processes, sophisticated regulatory mechanisms are ultimately ...
Jean-Marie eSontag, Estelle eSontag
doaj   +1 more source

Protein phosphatase 2A restrains DLK signaling to promote proper Drosophila synaptic development and mammalian cortical neuron survival

Neurobiology of Disease, 2022
Protein phosphatase 2A (PP2A) is a major cellular phosphatase with many protein substrates. As expected for a signaling molecule with many targets, inhibition of PP2A disrupts fundamental aspects of cellular physiology including cell division and ...
Margaret Hayne, Aaron DiAntonio
doaj   +1 more source

Activation of the Tumor Suppressor PP2A Emerges as a Potential Therapeutic Strategy for Treating Prostate Cancer

Marine Drugs, 2015
Protein phosphatase 2A (PP2A) is a tumor suppressor complex that has recently been reported as a novel and highly relevant molecular target in prostate cancer (PCa). However, its potential therapeutic value remains to be fully clarified.
Ion Cristóbal, Paula González-Alonso, Lina Daoud, Esther Solano, Blanca Torrejón, Rebeca Manso, Juan Madoz-Gúrpide, Federico Rojo, Jesús García-Foncillas   +8 more
doaj   +1 more source

Mutation of Arabidopsis SPLICEOSOMAL TIMEKEEPER LOCUS1 Causes Circadian Clock Defects [PDF]

, 2012
The circadian clock plays a crucial role in coordinating plant metabolic and physiological functions with predictable environmental variables, such as dusk and dawn, while also modulating responses to biotic and abiotic challenges.
Brown, John WS, Harmer, Stacey L, Jones, Matthew A, McNicol, Jim, Simpson, Craig G, Williams, Brian A   +5 more
core   +1 more source

CIP2A Inhibits PP2A in Human Malignancies [PDF]

Cell, 2007
Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. However, the molecular mechanisms by which PP2A activity is inhibited in human cancers are currently unclear. In this study, we describe a cellular inhibitor of PP2A with oncogenic activity. The protein, designated Cancerous
Centre for Biotechnology, University of Turku and Åbo Akademi University Turku, Finland ( host institution ), Junttila, Melissa R. ( author ), Puustinen, Pietri ( author ), Niemelä, Minna ( author ), Ahola, Raija ( author ), Arnold, Hugh ( author ), Böttzauw, Trine ( author ), Ala-aho, Risto ( author ), Nielsen, Christina ( author ), Ivaska, Johanna ( author ), Taya, Yoichi ( author ), Lu, Shi-Long ( author ), Lin, Shujun ( author ), Chan, Edward K.L. ( author ), Wang, Xiao-Jing ( author ), Grènman, Reidar ( author ), Kast, Juergen ( author ), Kallunki, Tuula ( author ), Sears, Rosalie ( author ), Kähäri, Veli-Matti ( author ), Westermarck, Jukka ( author )   +20 more
openaire   +5 more sources

Upregulated SET Promotes Cell Survival Through Activating Akt/NF-κB Signal in Colorectal Carcinoma

Cancer Management and Research, 2020
Jianjun Zhu,1 Lihong Shi,2 Genlai Du,1 Li Li,1 Ming Liu1 1Department of Medical Cellular Biology and Genetics, Shanxi Medical University, Taiyuan 030001, People’s Republic of China; 2Department of Human Anatomy, School of Basic Medicine, Shanxi ...
Zhu J, Shi L, Du G, Li L, Liu M
doaj  

Protein phosphatase 2A modulates podocyte maturation and glomerular functional integrity in mice

Cell Communication and Signaling, 2019
Background Protein phosphorylation & dephosphorylation are ubiquitous cellular processes that allow for the nuanced and reversible regulation of protein activity.
Xiujuan Zhu, Yuhong Ye, Chengxian Xu, Cunji Gao, Yingying Zhang, Jing Zhou, Weiqiang Lin, Jianhua Mao   +7 more
doaj   +1 more source

Protein phosphatase 2A as a therapeutic target in acute myeloid leukemia [PDF]

, 2016
Acute myeloid leukemia (AML) is a heterogeneous malignant disorder of hematopoietic progenitor cells in which several genetic and epigenetic aberrations have been described.
Adachi, Agarwal, Al-Murrani, Arnaud, Arnold, Barragan, Blalock, Blalock, Bononi, Bryan, Calin, Cancer Genome Atlas Research Network, Canela, Cervoni, Chen, Chen, Chen, Cheng, Christensen, Ciccone, Cohen, Come, Cristobal, Cristobal, Cristobal, Cristobal, Cristobal, Dohner, Dong, Eichhorn, Esplin, Estella-Hermoso de Mendoza, Fan, Gallay, Gao, Grallert, Haesen, Ingwersen, Irie, Janghorban, Janssens, Jin, Junttila, Kalla, Kalousi, Kandilci, Kelly, Khanna, Khanna, Kuo, Kutney, Lambrecht, Letourneux, Leulliot, Li, Liu, Longin, Low, Lucas, Lucas, Luo, Ma, Marcucci, Margolis, Mumby, Naetar, Neviani, Neviani, Neviani, Niemela, Oaks, Ofran, Perot, Perrotti, Perrotti, Pippa, Price, Ramaswamy, Roberts, Rorick, Rowe, Ruediger, Ruediger, Ruvolo, Ruvolo, Ruvolo, Ruvolo, Sablina, Sablina, Saddoughi, Saito, Schonthal, Seeling, Seo, Seshacharyulu, Seval, Shah, Shouse, Shouse, Switzer, ten Klooster, Trotta, Trotta, Turowski, Vasudevan, Wang, Wang, Wang, Westermarck, Wong, Xu, Xue, Yan, Yang, Yang, Yohe, Yu, Zwaenepoel   +117 more
core   +3 more sources

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

A Novel Role of PP2A Methylation in the Regulation of Tight Junction Assembly and Integrity

Frontiers in Cell and Developmental Biology, 2022
Tight junctions (TJs) are multiprotein complexes essential for cell polarity and the barrier function of epithelia. The major signaling molecule, protein serine/threonine phosphatase 2A (PP2A), interacts with the TJ and modulates the phosphorylation ...
Diana Schuhmacher, Jean-Marie Sontag, Estelle Sontag   +2 more
doaj   +1 more source