Results 71 to 80 of about 55,976 (264)

MpPP2A-A gene cloning and knockout mutant constructing in Marchantia polymorpha

Guangxi Zhiwu
Protein phosphatase 2A(PP2A), a serine/threonine phosphatases, participates in many biological processes such as plant growth and development by dephosphorylating its substrate proteins.
LIU Wenzhen1,2,3, JIANG Xinhua1,2, ZHANG Bangyue1,2, CHEN Sha1,2, ZHANG Jingjing1,2, LI Xiangyuan1,2, RONG Duoyan1,2,3*
doaj   +1 more source

A Non-Radioactive Method for Measuring PP2A Activity in Plants

Bio-Protocol, 2015
Protein phosphatase 2A (PP2A) is a group of important cellular regulators in eukaryotes that dephosphorylate more than 30% of cellular proteins whose activities are turned on or off by phosphorylation.
Jian Chen, Guoxin Shen, Hong Zhang
doaj   +1 more source

UBE3A Inhibits Trophoblast Cell Migration and Invasion by Promoting ITGB1 Degradation and Affecting PI3K/AKT Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Preeclampsia (PE) is an obstetric disease that is characterized by reduced migration and invasion of placental trophoblast cells. Here, the effects of the E3 ubiquitin ligase UBE3A on the migration and invasion of trophoblast cells were evaluated.
Xiu‐Jun Li, Ning Wang, Fan Jiang, Jie‐Cheng Yang, Yan‐Yun Wang, Kun Wang   +5 more
wiley   +1 more source

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth [PDF]

, 2017
Targeted cancer therapies, which act on specific cancer-associated molecular targets, are predominantly inhibitors of oncogenic kinases. While these drugs have achieved some clinical success, the inactivation of kinase signaling via stimulation of ...
Avelar, RA, Borczuk, AC, Brautigan, DL, Chance, MR, Chen, EY, Datt, M, Dhawan, NS, DiFeo, A, Duan, Q, Farrington, CC, Galsky, MD, Giannini, HM, Gidwani, V, Gokulrangan, G, Haider, S, Hoon, D, Ioannou, YA, Izadmehr, S, Kastrinsky, DB, Kiselar, J, Leonard, D, Levine, AC, Mazhar, S, Ma’ayan, A, McClinch, K, McQuaid, D, Narla, G, Ohlmeyer, M, O’Connor, CM, Perl, A, Sangodkar, J, Schlatzer, D, Sears, RC, Sharma, N, Smith, B, Stachnik, A, Svenson, E, Tohme, R, Wang, L, Wang, Z, Wiredja, DD, Xu, W, Yao, S, Yuan, E, Zaware, N   +44 more
core   +1 more source

Cyanopeptide Mixtures Induce Variable Synergistic and Antagonistic Effects Across Diverse Human Cell Lines

Environmental Toxicology, EarlyView.
ABSTRACT Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as ...
Lauren N. Hart, Katherine L. Lev, Sierra Hefferan, Sanduni H. Premathilaka, Sharmila I. Thenuwara, Dragan Isailovic, David H. Sherman, Gregory J. Dick   +7 more
wiley   +1 more source

Hypoxia-activated Smad3-specific Dephosphorylation by PP2A [PDF]

Journal of Biological Chemistry, 2010
The transforming growth factor-beta (TGF-beta) maintains epithelial homeostasis and suppresses early tumor formation, but paradoxically at later stages of tumor progression, TGF-beta promotes malignancy. TGF-beta activates phosphorylation of Smad2 and -3 effectors. Smad2 and -3 are known to have different functions, but differential regulation of their
Heikkinen, PT, Nummela, M, Leivonen, SK, Westermarck, J, Hill, CS, K\303\244h\303\244ri VM, Jaakkola, PM   +6 more
openaire   +3 more sources

Therapeutic reactivation of protein phosphatase 2A in acute myeloid leukemia

Frontiers in Oncology, 2015
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that is required for normal cell growth and development. PP2A is a potent tumor suppressor, which is inactivated in cancer cells as a result of genetic deletions and mutations.
Kavitha eRamaswamy, Barbara eSpitzer, Alex eKentsis   +2 more
doaj   +1 more source

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

eLife, 2020
Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers, and partial loss of PP2A function contributes to cell transformation.
Jong Wook Kim, Christian Berrios, Miju Kim, Amy E Schade, Guillaume Adelmant, Huwate Yeerna, Emily Damato, Amanda Balboni Iniguez, Laurence Florens, Michael P Washburn, Kim Stegmaier, Nathanael S Gray, Pablo Tamayo, Ole Gjoerup, Jarrod A Marto, James DeCaprio, William C Hahn   +16 more
doaj   +1 more source

Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma. [PDF]

PLoS ONE, 2011
BACKGROUND: Corticosteroid insensitivity is a major barrier of treatment for some chronic inflammatory diseases, such as severe asthma, but the molecular mechanism of the insensitivity has not been fully elucidated.
Yoshiki Kobayashi, Nicolas Mercado, Peter J Barnes, Kazuhiro Ito   +3 more
doaj   +1 more source

An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice. [PDF]

, 2019
Chronic or excess glucocorticoid exposure causes lipid disorders such as hypertriglyceridemia and hepatic steatosis. Angptl4 (angiopoietin-like 4), a primary target gene of the glucocorticoid receptor in hepatocytes and adipocytes, is required for ...
Cheang, Rachel T, Chen, Tzu-Chieh, Fitch, Mark D, Gray, Nora E, Hellerstein, Marc K, Kanamaluru, Deepthi, Lee, Justin Y, Lee, Rebecca A, Tan, Jenna H, Tsai, Sam L, Wang, Jen-Chywan, Yiv, Nicholas   +11 more
core