Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion
, 2017 Perturbation of the gut-associated microbial community may underlie many human illnesses, but the mechanisms that maintain homeostasis are poorly understood.
Giulivi, Cecilia +37 more
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Reporter gene HEK 293 cells and WNT/Frizzled fusion proteins as tools to study WNT signaling pathways [PDF]
, 2011 WNT/Frizzled receptor (FZD) signaling pathways are pivotal for physiological and pathophysiological processes. In humans, the complexity of WNT/FZD signaling is based on 19 WNTs, 10 FZDs and at least two (co)receptors (LRP5/6) mediating supposably four ...
Marisa Karow, +17 more
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The sensory system acts with a neuromedin U signaling pathway to mediate food type-dependent effects on lifespan [PDF]
, 2010 In order to survive, the animal uses its sensory system to interpret the complexity of its environment. Interestingly, a subset of sensory neurons, which function in taste or olfaction, has been found to influence the lifespan of C.
Adilov, Bakhtiyor
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Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes [PDF]
, 2006 Background: PPARs exhibit anti-inflammatory capacities and are potential modulators of the inflammatory response. We hypothesized that their expression and/or function may be altered in cystic fibrosis (CF), a disorder characterized by an excessive host ...
Wagner, Thomas +17 more
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The PPARy ligand rosiglitazone influences triacylglycerol metabolism in non-obese males, without increasing the transcriptional activity of PPARy in the subcutaneous adipose tissue [PDF]
, 2008 PPAR¿ is obligatory for fat mass generation and is thought to determine the amount of TAG stored per fat cell. We investigated whether ligand availability for PPAR¿ is rate limiting in fat mass generation and substrate metabolism.
Kersten, A.H. +3 more
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Wnt signaling pathway in retinal vascularization
, 2016 Kimberly A Drenser Associated Retinal Consultants, Royal Oak, MI, USA Abstract: Wnt-signaling, a ubiquitous pathway that directs differentiation, cell polarity, and tissue specificity, has been implicated as an important gene-expression pathway in ...
Drenser KA
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The Sonic Hedgehog Pathway Stimulates Prostate Tumor Growth by Paracrine Signaling and Recaptures Embryonic Gene Expression in Tumor Myofibroblasts [PDF]
, 2009 The Hedgehog (Hh) pathway contributes to prostate cancer growth and progression. The presence of robust Shh expression in both normal prostate and localized cancer challenged us to explain the unique growth promoting effect in cancer.
Aubie Shaw, Jerry Gipp, Wade Bushman
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critical role of PPAR-γ signaling pathway
, 2017 Galangin (3,5,7-trihydroxyflavone), a flavonol compound isolated from Alpinia officinarum, has anti-cancer, anti-oxidant, anti-inflammatory, anti-proliferative and neuroprotective effects.
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Diabetes Promotes Myocardial Fibrosis via AMPK/EZH2/PPAR-γ Signaling Pathway
Diabetes & Metabolism JournalBackground: Diabetes-induced cardiac fibrosis is one of the main mechanisms of diabetic cardiomyopathy. As a common histone methyltransferase, enhancer of zeste homolog 2 (EZH2) has been implicated in fibrosis progression in multiple organs. However, the mechanism of EZH2 in diabetic myocardial fibrosis has not been clarified.Methods: In the current ...
Shan-Shan Li +10 more
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PPAR-ϒ Pathway to Vascular Dysfunction [PDF]
, 2012 Humans with dominant-negative (DN) mutations in PPAR-ϒ develop early onset hypertension. A recent study by Pelham et al. (2012) shows that loss of PPAR-ϒ repression of the Rho kinase pathway leads to altered vascular function via a smooth-muscle ...
Lombard, Julian H., Cowley, Allen W.
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