Results 41 to 50 of about 1,781,780 (142)

Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and in HuH7 cells. [PDF]

, 2013
Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through ...
Enrich Bastús, Carles, Enrich Carlos, Karen Cecilia Chan, Monira Hoque, Darabi, Masoud, Reverter Martín, Meritxell, Hoque, Monira, Rentero Alfonso, Carles, Meritxell Reverter, Rentero Carles, Melanie Manetsch, Masoud Darabi, Mulay, Vishwaroop, Peta Wood, Grewal Thomas, Álvarez-Guaita, Anna, Heeren, Joerg, Anna Alvarez-Guaita, Kerry-Anne Rye, Darabi Masoud, Rye Kerry-Anne, Chan, Karen Cecilia, Manetsch, Melanie, Mulay Vishwaroop, Manetsch Melanie, Heeren Joerg, Carlos Enrich, Cairns, Rose, Reverter Meritxell, Joerg Heeren, Carles Rentero, Vishwaroop Mulay, Rose Cairns, Wood Peta, Wood, Peta, Grewal, Thomas, Rye, Kerry-Anne, Chan Karen Cecilia, Álvarez-Guaita Anna, Thomas Grewal, Hoque Monira, Cairns Rose   +41 more
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Regulation of Ketogenic Enzyme HMGCS2 by Wnt/β-catenin/PPARγ Pathway in Intestinal Cells

, 2019
The Wnt/β-catenin pathway plays a crucial role in development and renewal of the intestinal epithelium. Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), a rate-limiting ketogenic enzyme in the synthesis of ketone body &beta ...
Chang Li, Heidi L. Weiss, Qingding Wang, Ji Tae Kim, Chunming Liu, Yuning Zhou, B. Mark Evers   +6 more
core   +1 more source

rSj16 Protects against DSS-Induced Colitis by Inhibiting the PPAR-α Signaling Pathway

Theranostics, 2017
Background: Epidemiologic studies and animal model experiments have shown that parasites have significant modulatory effects on autoimmune disorders, including inflammatory bowel disease (IBD). Recombinant Sj16 (rSj16), a 16-kDa secreted protein of Schistosoma japonicum (S.japonicum) produced by Escherichia coli (E.
Wang, Lifu, Xie, Hui, Xu, Lian, Liao, Qi, Wan, Shuo, Yu, Zilong, Lin, Datao, Zhang, Beibei, Lv, Zhiyue, Wu, Zhongdao, Sun, Xi   +10 more
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Dissecting the roles of WNT signaling in breast cancer using "in vitro" and "in vivo" experimental models [PDF]

, 2009
Canonical WNT pathway regulates expression of target genes by modulating intracellular amount of β-catenin. Without WNT pathway activation, a so-called “destruction complex” including APC and Axin facilitates the degradation of β-catenin. Upon binding of
Matsuda, Yutaka
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010 Demystification of the effects of docosahexaenoic acid on the PPAR signaling pathway in psoriasis [PDF]

Journal of Investigative Dermatology, 2021
S. Morin, M. Simard, R. Pouliot
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Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling [PDF]

, 2012
Many cellular processes including apoptosis, autophagy, translation, energy metabolism, and inflammation are controlled by the mammalian target of rapamycin (mTOR) kinase and the endoplasmic reticulum (ER) stress pathway, also known as the unfolded ...
Appenzeller-Herzog, Christian, Hall, Michael N.   +1 more
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Saikosaponin a attenuates hyperlipidemic pancreatitis in rats via the PPAR‑γ/NF‑κB signaling pathway

Experimental and Therapeutic Medicine, 2019
The therapeutic effect of saikosaponin a (SSa) on hyperlipidemic pancreatitis (HP) is not completely understood. The aim of the present study was to investigate the therapeutic effect and the underlying mechanism of SSa using a rat model of HP. Following successful establishment of the HP rat model, different doses of SSa (low dose group, 10 mg/kg or ...
Feng, Pingping, Xu, Yanfang, Tong, Baoyan, Tong, Xiaoqun, Bian, Yinyan, Zhao, Shufen, Shen, Hongbo   +6 more
openaire   +3 more sources

Oxidative Stress and the Nrf2/PPARγ Axis in the Endometrium: Insights into Female Fertility

Successful pregnancy depends on precise molecular regulation of uterine physiology, especially during the menstrual cycle. Deregulated oxidative stress (OS), often influenced by inflammatory changes but also by environmental factors, represents a ...
Zuzana Badovská, Gabriela Sabolová, Ivana Špaková, Eva Kriváková, Peter Artimovič, Silvia Toporcerová, Lukáš Smolko, Miroslava Rabajdová   +7 more
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Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk [PDF]

, 2010
Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor proteins, the SH2B proteins.
Linda Partridge, Partridge, L., Withers, D., Stocker, H, Withers, D.J., Foley, A., Foley, Andrea, Hafen, Ernst, Cathy Slack, Thornton, Janet M., Werz, C, Wieser, D, Stocker, Hugo, Thornton, J., Slack, C, Wieser, D., Werz, C., Hafen, E, Withers, Dominic J., Hafen, E., Lu, Bingwei, Dominic J Withers, Nazif Alic, Janet M Thornton, Werz, Christian, Alic, N, Stocker, H., Withers, DJ, Ernst Hafen, Partridge, Linda, Slack, Cathy, Hugo Stocker, Andrea Foley, Wieser, Daniela, Foley, A, Alic, Nazif, Partridge, L, Christian Werz, Thornton, JM, Alic, N., Daniela Wieser, Slack, C., Lu, B., Thornton, J. M.   +43 more
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Baicalin alleviates sepsis-associated acute kidney injury through activation of the PPAR-γ/UCP1 signaling pathway

Purpose This study aims to investigate the protective effect of baicalin on sepsis-associated acute kidney injury (SA-AKI) and its molecular mechanism.Materials and methods An SA-AKI mouse model was established via lipopolysaccharide (LPS) injection ...
Qing-Bo Lu, Neng Bao, Jin Wang, Xin Gu, Xue-Xue Zhu, Ya-Fen Yu, Ming-Jia Gu, Xiang Yu, Hai-Jian Sun, Qiu-Ya Huang   +9 more
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