Results 61 to 70 of about 1,781,780 (142)

Supplementary Material for: L-Carnitine Ameliorates Cancer Cachexia in Mice Partly via the Carnitine Palmitoyltransferase-Associated PPAR-γ Signaling Pathway

, 2017
Background:L-Carnitine has been demonstrated to ameliorate cachectic symptoms. In the present study, we sought to investigate the role of the peroxisome proliferator-activated receptor-γ (PPAR-γ) signaling pathway in the ameliorative effects of L ...
Jiang F. (4156609), Pan X. (4156612), Liu S. (3777670), Zhang Z. (3341231), Zhang Y. (2828780), Yu L. (3691228)   +5 more
core   +1 more source

Thymidine exerts anti-doxorubicin-induced cardiomyopathy effect through the regulation of the PPAR signaling pathways and ferroptosis pathways

Frontiers in Pharmacology
IntroductionTo evaluate the anti-cardiomyopathic activity of thymine (Thy) and to elucidate its mechanism of action.MethodsTransgenic zebrafish with enhanced green fluorescent protein (EGFP)-labelled hearts (Tg (cmlc2: EGFP)) and wild-type AB zebrafish were used as experimental animals.
Li, Bin, Wang, Qifei, Zhou, Jiashuo, Li, Peihai, Sun, Chen, Xia, Qing, Zhang, Yun   +6 more
openaire   +2 more sources

Associating GWAS Information with the Notch Signaling Pathway Using Transcription Profiling

, 2011
Genome-wide association studies (GWAS) have identified SNPs associated with breast cancer. However, they offer limited insights about the biological mechanisms by which SNPs confer risk.
Chindo Hicks, Lucio Miele, Antonio Pannuti   +2 more
core   +1 more source

A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways

, 2018
Mitochondrial dysfunctions activate retrograde signaling from mitochondria to the nucleus. To identify transcription factors and their associated pathways that underlie mitochondrial retrograde signaling, we performed gene expression profiling of the ...
Sehyun Chae, Cho, YM, Hwang, D, Lee, B, Ahn, BY, Park, KS, Byun, K, Yu, MH   +7 more
core   +1 more source

Apoptotic cells trigger the ABCA1/STAT6 pathway leading to PPAR- expression and activation in macrophages

, 2018
The signal transducer and activator of transcription 6 (STAT6) transcription factor activates peroxisome proliferator-activated receptor gamma (PPAR-)-regulated gene expression in immune cells.
이지희, 김희선
core   +2 more sources

Peroxisome proliferator-activated receptor gamma inhibits cell growth and negatively regulates DNA methyltransferase promoter activity in SK-N-AS neuroblastoma cells

, 2011
Neuroblastoma is the most common extra-cranial childhood solid tumour which arises from embryonic neural crest cells that fail to undergo a differentiation programme to form mature sympathetic neurones.
Huang, Chih-Hua
core   +1 more source

Lysophospholipid-Related Diseases and PPAR gamma Signaling Pathway

Lysophospholipid-Related Diseases and PPAR gamma Signaling Pathway
The nuclear receptor superfamily includes ligand-inducible transcription factors that play diverse roles in cell metabolism and are associated with pathologies such as cardiovascular diseases. Lysophosphatidic acid (LPA) belongs to a family of lipid mediators.
openaire   +1 more source

ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway. [PDF]

Biol Direct, 2023
Cao Y, Li J, Qiu S, Ni S, Duan Y.
europepmc   +1 more source

Frizzled Proteins are bona fide G Protein-Coupled Receptors [PDF]

, 2009
Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controlling multiple steps in organism development and highly conserved in evolution. Misactivation of the Wnt/Frizzled signaling is cancerogenic.
Silke Buestorf, Vladimir L. Katanaev
core  

Transcriptome and Metabolome Analyses Reveal Perfluorooctanoic Acid-Induced Kidney Injury by Interfering with PPAR Signaling Pathway. [PDF]

Int J Mol Sci, 2023
Zhang Y, Li Y, Gao N, Gong Y, Shi W, Wang X.   +5 more
europepmc   +1 more source