Results 1 to 10 of about 14,459 (136)
The constancy of global regulation across a species: the concentrations of ppGpp and RpoS are strain-specific in
BMC Microbiology, 2011 Background Sigma factors and the alarmone ppGpp control the allocation of RNA polymerase to promoters under stressful conditions. Both ppGpp and the sigma factor σS (RpoS) are potentially subject to variability across the species Escherichia coli.
Phan Katherine +4 more
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Role of (p)ppGpp in Viability and Biofilm Formation of Actinobacillus pleuropneumoniae S8. [PDF]
PLoS ONE, 2015 Actinobacillus pleuropneumoniae is a Gram-negative bacterium and the cause of porcine pleuropneumonia. When the bacterium encounters nutritional starvation, the relA-dependent (p)ppGpp-mediated stringent response is activated.
Gang Li +5 more
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Enzymatic activity of PBP1B is required for growth rate-independent ppGpp-mediated resistance to PBP2 inhibitors in E. coli [PDF]
Journal of BacteriologyThe alarmone (p)ppGpp (ppGpp) accumulates in response to starvation and other stress, leading to inhibition of multiple biosynthetic pathways and, at high concentrations, suppression of bacterial growth.
Sarah E. Anderson +2 more
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Analysis of (p)ppGpp metabolism and signaling using a dynamic luminescent reporter. [PDF]
PLoS GeneticsAs rapidly growing bacteria begin to exhaust nutrients, their growth rate slows, ultimately leading to the non-replicative state of quiescence. Adaptation to nutrient limitation requires widespread metabolic remodeling that is in part mediated by the ...
Molly Hydorn +4 more
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(p)ppGpp imposes graded transcriptional changes to impair motility and promote antibiotic tolerance in biofilms [PDF]
npj Biofilms and Microbiomes(p)ppGpp is the master regulator of bacterial stress responses, orchestrating cellular physiology via the stringent response to promote survival and adaptation.
Florian Engelhardt +6 more
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Functional interplay between (p)ppGpp and RNAP in Acinetobacter baumannii. [PDF]
PLoS PathogensThe (p)ppGpp-dependent stress response is required for pathogenic bacteria to survive both outside and inside the host but the mechanisms behind this survival are mostly unknown. In this study, we characterize the (p)ppGpp metabolism in the opportunistic
Anthony Perrier +2 more
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Estudo & Debate, 2023 O objetivo neste artigo é discutir os efeitos da reforma trabalhista (Lei n° 13.467/2017) no sistema de proteção social brasileiro. Metodologicamente, a pesquisa ampara-se na ótica da Economia Social e do Trabalho via diferentes correntes teóricas que ...
Juliano Vargas, William Sousa Vilanova
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NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli
eLife, 2021 Bacteria regulate their metabolism to adapt and survive adverse conditions, in particular to stressful downshifts in nutrient availability. These shifts trigger the so-called stringent response, coordinated by the signaling molecules guanosine tetra and ...
Loïc Léger +4 more
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eLife, 2022 Guanosine pentaphosphate and tetraphosphate (together referred to as ppGpp) are hyperphosphorylated nucleotides found in bacteria and the chloroplasts of plants and algae.
Shanna Romand +12 more
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Communications Biology, 2023 The cyanobacterium Synechococcus elongatus PCC 7942 accumulates alarmone guanosine tetraphosphate (ppGpp) under stress conditions, such as darkness. A previous study observed that artificial ppGpp accumulation under photosynthetic conditions led to the ...
Ryota Hidese +8 more
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