Results 91 to 100 of about 14,528 (201)

Crucial Role of ppGpp in the Resilience of Escherichia coli to Growth Disruption

mSphere, 2020
Bacteria grow in constantly changing environments that can suddenly become completely depleted of essential nutrients. The stringent response, a rewiring of the cellular metabolism mediated by the alarmone (p)ppGpp, plays a crucial role in adjusting ...
Clément Patacq, Nicolas Chaudet, Fabien Létisse   +2 more
doaj   +1 more source

The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase [PDF]

, 2013
RbpA is a small non-DNA-binding transcription factor that associates with RNA polymerase holoenzyme and stimulates transcription in actinobacteria, including Streptomyces coelicolor and Mycobacterium tuberculosis.
Aline Tabib-Salazar, Alting-Mees, Babcock, Bergendahl, Bierman, Bing Liu, Bougdour, Bucca, Burgess, Buttner, Campbell, Campbell, Chakraburtty, Cornilescu, Dey, England, Feklistov, Fletcher, Fontán, Forti, Gaal, Gabriel, Gruber, Haugen, Herring, Hsu, Hu, Hu, Huang, Karimova, Karimova, Kathleen O’Dwyer, Kelemen, Kelley, Kieser, Kim, Krishna, Manganelli, Manganelli, Mantsyzov, Marchant, Marie-Laure Parsy, Mark S. Paget, McClellan, Monteil, Monteil, Murakami, Newell, Otani, O’Connor, Paget, Paget, Paget, Paget, Panina, Peter J. Simpson, Philip Doughty, Pratt, Raffaelle, Richard A. Lewis, Rieping, Saecker, Sattler, Schwartz, Selmer, Sivashanmugam, Somadri Ghosh, Steve J. Matthews, Studier, Studier, Typas, van Wezel, Vassylyev, Ventura, Viollier, Vockenhuber, Wang, WHO, Young, Zhang, Zhang, Zhuo, Österberg   +82 more
core   +1 more source

Condition‐dependent resource allocation strategy governed by CodY regulator in Bacillus subtilis

mLife, Volume 4, Issue 5, Page 539-550, October 2025.
Abstract To thrive in nature, bacteria have to rapidly proliferate in favorable conditions while constantly adapt to the fluctuating nutrient environments. However, the molecular players that ensure rapid growth of bacteria in favorable conditions remain poorly understood.
Haoyan Mu, Yiheng Wang, Yongfu Pei, Xin Wang, Xiongfeng Dai, Manlu Zhu   +5 more
wiley   +1 more source

On the Turnover of ppGpp in Escherichia coli

Journal of Biological Chemistry, 1972
Abstract The ribosome inhibitor chloramphenicol brings about a rapid disappearance of ppGpp in both RC+ and RC- cells, suggesting that the antibiotic inhibits the synthesis of ppGpp. The kinetics of ppGpp decay in the presence of chloramphenicol agrees well with the kinetics of ppGpp accumulation, in the antibiotic's absence, both in RC+ cells ...
J, Gallant, G, Margason, B, Finch
openaire   +2 more sources

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

Biotechnology and Bioengineering, Volume 122, Issue 9, Page 2456-2464, September 2025.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer, Franziska Guld, Bernd Nidetzky   +2 more
wiley   +1 more source

Bacillus subtilis produces (p)ppGpp in response to the bacteriostatic antibiotic chloramphenicol to prevent its potential bactericidal effect

mLife, 2022
Antibiotics combat bacteria through their bacteriostatic (by growth inhibition) or bactericidal (by killing bacteria) action. Mechanistically, it has been proposed that bactericidal antibiotics trigger cellular damage, while bacteriostatic antibiotics ...
Jin Yang, Jessica T. Barra, Danny K. Fung, Jue D. Wang   +3 more
doaj   +1 more source

Characterization of water and wildlife strains as a subgroup of Campylobacter jejuni using DNA microarrays.

, 2013
Campylobacter jejuni is the leading cause of human bacterial gastroenteritis worldwide, but source attribution of the organism is difficult. Previously, DNA microarrays were used to investigate isolate source, which suggested a non-livestock source of ...
Altschul, Brandl, Champion, Dingle, Dingle, Dorrell, Ethelberg, Francisco, French, Gundogdu, Harris, Hepworth, Hepworth, Hinchliffe, Howard, Huelsenbeck, Jensen, Jorgensen, Joshua, Kalendar, Karenlampi, Katoh, Katoh, Kemp, Kim, Kim, King, Kwan, Kwan, Manning, McCarthy, Mellmann, Miller, Moen, Murphy, Ogden, On, Park, Pearson, Petersen, Ronquist, Rosef, Rosef, Sails, Sanad, Schonberg-Norio, Skirrow, Skirrow, Stabler, Staden, Staden, Taboada, Taboada, Tam, Tam, Wilson   +55 more
core   +1 more source

ppGpp Formation in Escherichia coli Treated with Rifampicin

Journal of Biological Chemistry, 1971
Abstract It has been previously reported that the accumulation of the regulatory nucleotide ppGpp (MS I), which is governed by the RC gene of Escherichia coli, does not occur in the presence of rifampicin. Since this drug inhibits RNA chain initiation, it was suggested that the formation of ppGpp is somehow dependent on the presence of nascent RNA ...
H, Erlich, T, Laffler, J, Gallant
openaire   +2 more sources

Regulation of ς factor competition by the alarmone ppGpp [PDF]

Genes & Development, 2002
Many regulons controlled by alternative ς factors, including ς S and ς 32 , are poorly induced in cells lacking the alarmone ppGpp. We show that ppGpp is not absolutely required for the activity of ς S -dependent ...
Miki, Jishage, Kristian, Kvint, Victoria, Shingler, Thomas, Nyström   +3 more
openaire   +2 more sources

Arctic Soil C and N Cycling Are Linked With Microbial Adaptations During Drought

Global Change Biology, Volume 31, Issue 9, September 2025.
To understand responses of Arctic microbial carbon and nitrogen cycling to climate change, we simulated a drought event in a laboratory experiment and tracked microbial gene expression and greenhouse gas emissions across increasing levels of drought.
Theis Thomsen, Morten Dencker Schostag, Anders Priemé, Jonathan Donhauser   +3 more
wiley   +1 more source