Results 111 to 120 of about 4,765 (208)

Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?

Microbial Cell, 2023
The bacterial stringent response and its effector alarmone guanosine penta- or tetra – phosphates (p)ppGpp are vital for bacterial tolerance and survival of various stresses in environments (including antibiotics) and host cells (viru-lence).
Paulina Katarzyna Grucela, Tobias Fuhrer, Uwe Sauer, Yanjie Chao, Yong Everett Zhang   +4 more
doaj   +1 more source

Quinolone tolerance in Escherichia coli due to defects in the adenosine ribonucleotides de novo biosynthesis pathway

mLife, Volume 5, Issue 2, Page 217-228, April 2026.
Abstract Central carbon metabolism is thought to link reactive oxygen species (ROS) with antibiotic‐mediated bacterial death. During enrichment screening of Escherichia coli with the first‐generation quinolone oxolinic acid, unstable antibiotic‐tolerant mutants containing deficiencies in purB were obtained.
Weiwei Zhu, Yuejuan Nong, Jie Su, Jingwen Yang, Lina Ma, Yunxin Xue, Dai Wang, Jianjun Niu, Karl Drlica, Xilin Zhao   +9 more
wiley   +1 more source

Pleiotropic Effects of Bacterial Small Alarmone Synthetases: Underscoring the Dual-Domain Small Alarmone Synthetases in Mycobacterium smegmatis

Frontiers in Microbiology, 2020
The nucleotide alarmone (p)ppGpp, signaling the stringent response, is known for more than 5 decades. The cellular turnover of the alarmone is regulated by RelA/SpoT homolog (RSH) superfamily of enzymes.
Sushma Krishnan, Dipankar Chatterji
doaj   +1 more source

Broad-spectrum anti-biofilm peptide that targets a cellular stress response. [PDF]

PLoS Pathogens, 2014
Bacteria form multicellular communities known as biofilms that cause two thirds of all infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional antibiotics.
César de la Fuente-Núñez, Fany Reffuveille, Evan F Haney, Suzana K Straus, Robert E W Hancock   +4 more
doaj   +1 more source

Genome‐wide screen reveals a universal role of ATP in ciprofloxacin tolerance among genetically distinct Escherichia coli persisters

mLife, Volume 5, Issue 2, Page 180-198, April 2026.
Abstract Bacterial persisters show tolerance to bactericidal antibiotics and play essential roles in chronic infections; however, the general mechanisms underlying persister formation and antibiotic tolerance remain insufficiently characterized. In this study, the Escherichia coli Keio library was used to identify genes involved in ciprofloxacin ...
Zhenfang Mei, Yawen Cai, Jianfeng Huang, Kedong Zhao, Zuqin Zhang, Dandan Yu, Shiyan Lu, Zeying Lai, Thomas K. Wood, Xinmiao Fu   +9 more
wiley   +1 more source

Enzymatic activity of PBP1B is required for growth rate-independent ppGpp-mediated resistance to PBP2 inhibitors in E. coli

Journal of Bacteriology
The alarmone (p)ppGpp (ppGpp) accumulates in response to starvation and other stress, leading to inhibition of multiple biosynthetic pathways and, at high concentrations, suppression of bacterial growth.
Sarah E. Anderson, Isabella E. Mack, Petra Anne Levin   +2 more
doaj   +1 more source

Ribosome State Distributions Define Escherichia coli Persister Physiology: Links to Formation, Stress Responses, and Resuscitation Dynamics

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The AUCS70/AUCS100 ratio, derived from ribosome sedimentation profiling, quantitatively distinguishes Escherichia coli persisters from growing cells across multiple stress conditions and identifies RMF as the primary target for anti‐persistence strategies. ABSTRACT Persister cells survive antibiotic exposure and contribute to infection relapse, yet the
Hyein Kim, Sooyeon Song
wiley   +1 more source

The relative proportions of ppGpp-repressed and ppGpp-activated TSSs within the S. Typhimurium genome at LSP.

, 2014
The relative proportions of ppGpp-repressed and ppGpp-activated TSSs within the S. Typhimurium genome at LSP.
Vinoy K. Ramachandran (237946), Neil Shearer (207315), Arthur Thompson (207311)   +2 more
core   +1 more source

ppGpp Ribosome Dimerization Model for Bacterial Persister Formation and Resuscitation

bioRxiv, 2019
Stress is ubiquitous for bacteria and converts a subpopulation of cells into a dormant state known as persistence, in which cells are tolerant to antimicrobials.
Sooyeon Song, T. Wood
semanticscholar   +1 more source

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source