Results 121 to 130 of about 4,765 (208)

Analysis of (p)ppGpp metabolism and signaling using a dynamic luminescent reporter.

PLoS Genetics
As rapidly growing bacteria begin to exhaust nutrients, their growth rate slows, ultimately leading to the non-replicative state of quiescence. Adaptation to nutrient limitation requires widespread metabolic remodeling that is in part mediated by the ...
Molly Hydorn, Sathya Narayanan Nagarajan, Elizabeth Fones, Caroline S Harwood, Jonathan Dworkin   +4 more
doaj   +1 more source

Exploring Multifunctional Microbial Genes From the Rhizosphere of Allium ampeloprasum Under Different Fertilization Systems

Environmental DNA, Volume 8, Issue 2, March/April 2026.
This study uncovers key multifunctional genes in the rhizosphere of Allium ampeloprasum under varying fertilization systems. This highlights their roles in nutrient cycling, plant growth promotion, and soil health, thereby offering insight for sustainable agricultural sustainability.
Oluwaseun Emmanuel Shittu, Ben Jesuorsemwen Enagbonma, Olubukola Oluranti Babalola   +2 more
wiley   +1 more source

Peptide 1018 bound to ppGpp in vitro and led to degradation of (p)ppGpp in vivo.

, 2014
(A) Binding of peptide 1018 to various nucleotides based on co-precipitation. Peptide 1018 (0.25 mM) was separately mixed with increasing amounts of ppGpp, GTP, ATP, GDP and ADP in buffer (50 mM Tris, pH 7.4) and the extent of co-precipitation was ...
César de la Fuente-Núñez (567571), Fany Reffuveille (567572), Evan F. Haney (567573), Suzana K. Straus (567574), Robert E. W. Hancock (57521)   +4 more
core   +1 more source

Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel.

Cell Reports, 2020
The stringent response enables metabolic adaptation of bacteria under stress conditions and is governed by RelA/SpoT Homolog (RSH)-type enzymes. Long RSH-type enzymes encompass an N-terminal domain (NTD) harboring the second messenger nucleotide (p)ppGpp
P. Pausch, M. Abdelshahid, Wieland Steinchen, Heinrich Schäfer, F. Gratani, S. Freibert, C. Wolz, Kürşad Turgay, Daniel N. Wilson, G. Bange   +9 more
semanticscholar   +1 more source

Oxidative Treatment for Reducing Persistent Populations of Escherichia coli Under Amoxicillin and Gentamicin Pressure

Journal of Biophotonics, Volume 19, Issue 3, March 2026.
Photodynamic inactivation (PDI) with methylene blue and 660 nm LED enhances antibiotic killing of bacteria, accelerating time‐kill kinetics and reducing the MDK99 compared to antibiotics alone. SEM confirms effective cellular damage, demonstrating that PDI potentiates amoxicillin and gentamicin against tolerant bacterial populations. ABSTRACT Bacterial
Bruna C. Correa, Maria Vitória S. Pereira, Vanderlei S. Bagnato, Kate C. Blanco   +3 more
wiley   +1 more source

Differential regulation by ppGpp versus pppGpp in Escherichia coli

, 2013
Both ppGpp and pppGpp are thought to function collectively as second messengers for many complex cellular responses to nutritional stress throughout biology.
Murakami, Katsuhiko S, Cashel, Michael, Katsuhiko S. Murakami, Katarzyna Potrykus, Potrykus, Katarzyna, Michael Cashel, Mechold, Undine, Undine Mechold, Murphy, Helen, Helen Murphy   +9 more
core   +1 more source

Bacteriophage Therapy: Current Strategies and Future Perspectives

MedComm, Volume 7, Issue 3, March 2026.
This manuscript systematically reviews the expanding scope of phage applications. It moves beyond traditional antibacterial use to explore their role in precision therapies against drug‐resistant infections, their synergy with antibiotics, and advanced biomaterial‐assisted delivery systems.
Zihe Zhou, Hanyu Fu, Mengzhe Li, Zhongyu Han, Zhenchao Wu, Huahao Fan, Ning Shen, Jiajia Zheng   +7 more
wiley   +1 more source

Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp

, 2000
Reductions in growth rate caused by fusidic acid-resistant EF-G mutants in Salmonella typhimurium correlate strongly with increased mean cell size. This is unusual because growth rate and cell size normally correlate positively.
Ehrenberg, Måns,, Ehrenberg, Måns, Macvanin, Mirjana, Hughes, Diarmaid, Johanson, Urban,, Macvanin, Mirjana,, Johanson, Urban, Hughes, Diarmaid,   +7 more
core   +1 more source

Phenotypic and Functional Characterization of Human Memory T Cell Responses to Burkholderia pseudomallei [PDF]

, 2009
Copyright: © 2009 Tippayawat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and ...
Direk Limmathurotsakul, Suwannasaen, D, Sharon J Peacock, Ganjana Lertmemongkolchai, Titball, Richard W., Helen S Atkins, Tippayawat, Patcharaporn, Richard W Titball, Saenwongsa, Wipawee, Duangchan Suwannasaen, Chetchotisakd, Ploenchan, Chetchotisakd, P, Wipawee Saenwongsa, Jirawan Mahawantung, Philip L Felgner, Bancroft, Gregory J., Saenwongsa, W, Titball, RW, Atkins, Helen S, Mahawantung, J, Limmathurotsakul, Direk, Peacock, Sharon J., Limmathurotsakul, D, Mahawantung, Jirawan, Gregory J Bancroft, Suwannasaen, Duangchan, Peacock, SJ, Tippayawat, P, Atkins, HS, Titball, Richard W, Felgner, Philip L., Lertmemongkolchai, Ganjana, Felgner, Philip L, Ploenchan Chetchotisakd, Felgner, PL, Bancroft, GJ, Atkins, Helen S., Lertmemongkolchai, G, Bancroft, Gregory J, Peacock, Sharon J, Patcharaporn Tippayawat   +40 more
core   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, Volume 22, Issue 16, 17 March 2026.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source