Results 131 to 140 of about 7,972 (181)
Controlled Delivery and Light-Induced Release of Magic Spot Nucleotides in Escherichia coli
Popp C +10 more
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Transcriptional Responses to ppGpp and DksA [PDF]
Annual Review of Microbiology, 2018 The stringent response to nutrient deprivation is a stress response found throughout the bacterial domain of life. Although first described in proteobacteria for matching ribosome synthesis to the cell's translation status and for preventing formation of defective ribosomal particles, the response is actually much broader, regulating many hundreds of ...
Wilma Ross +2 more
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1974
Abstract The chemical synthesis of ppGpp (guanosine 3′,5′-dipyrophosphate) is described. The synthesis started from guanosine 3′,5′-diphosphate. The acidlabile ethoxyethyl group was used to protect the 2′-OH functional group. The pyrophosphate linkages were built up simultaneously according to the anionexchange method and the protecting group was ...
A, Simoncsits, J, Tomasz
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Abstract The chemical synthesis of ppGpp (guanosine 3′,5′-dipyrophosphate) is described. The synthesis started from guanosine 3′,5′-diphosphate. The acidlabile ethoxyethyl group was used to protect the 2′-OH functional group. The pyrophosphate linkages were built up simultaneously according to the anionexchange method and the protecting group was ...
A, Simoncsits, J, Tomasz
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Journal of Molecular Biology, 2001
To determine the role of ppGpp in both negative and positive regulation of transcription initiation during exponential growth in Escherichia coli, we examined transcription in vivo and in vitro from the growth-rate-dependent rRNA promoter rrnB P1 and from the inversely growth-rate-dependent amino acid biosynthesis/transport promoters PargI, PhisG ...
Richard Gourse, Tamás Gaal
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To determine the role of ppGpp in both negative and positive regulation of transcription initiation during exponential growth in Escherichia coli, we examined transcription in vivo and in vitro from the growth-rate-dependent rRNA promoter rrnB P1 and from the inversely growth-rate-dependent amino acid biosynthesis/transport promoters PargI, PhisG ...
Richard Gourse, Tamás Gaal
exaly +3 more sources
Glyphosate induces the synthesis of ppGpp
Molecular Genetics and Genomics, 2018Glyphosate, the most widely used herbicide in both agricultural and urban areas is toxic for plants and for many bacterial species. The mechanism of action of glyphosate is through the inhibition of the EPSP synthase, a key enzyme in the biosynthetic pathway of aromatic amino acids.
Gabriela Torres Cruvinel +2 more
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ppGpp cycle in Escherichia coli
Molecular and General Genetics MGG, 1977Kinetics of accumulation and degradation of ppGpp and pppGpp were analysed in spoT+ and spoT strains of Escherichia coli. The experimental data in this paper indicate that on degradation ppGpp is not converted to pppGpp but instead is converted to GDP which is in turn phosphorylated to GTP.
C, Kari, I, Török, A, Travers
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Stringency without ppGpp accumulation
Nature, 1981Wild-type Escherichia coli deprived of a required amino acid shows a stringent response involving various alterations in the cell's normal physiology, including the arrest of net synthesis of stable (ribosomal and transfer) RNA, lipids, phospholipids and peptidoglycans1.
A, Spadaro +3 more
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Journal of Cellular Physiology, 2010
AbstractIn recent years, emerging and reemerging pathogens resistant to nearly all available antibiotics are on the rise. This limits the availability of effective antibiotics to treat infections, thus it is imperative to develop new drugs. The accumulation of alarmones guanosine tetraphosphate and guanosine pentaphosphate, collectively known as (p ...
Jun, Wu, Quanxin, Long, Jianping, Xie
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AbstractIn recent years, emerging and reemerging pathogens resistant to nearly all available antibiotics are on the rise. This limits the availability of effective antibiotics to treat infections, thus it is imperative to develop new drugs. The accumulation of alarmones guanosine tetraphosphate and guanosine pentaphosphate, collectively known as (p ...
Jun, Wu, Quanxin, Long, Jianping, Xie
openaire +2 more sources
Journal of Cellular Physiology, 2009
AbstractGuanosine 5′‐(tri)diphosphate, 3′‐diphosphate [(p) ppGpp] is a small nucleic acid that helps bacteria survive in limited environments. Gene chip shows that (p) ppGpp is a global transcription‐regulator of genes related to important bacterial metabolic processes.
Jun, Wu, Jianping, Xie
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AbstractGuanosine 5′‐(tri)diphosphate, 3′‐diphosphate [(p) ppGpp] is a small nucleic acid that helps bacteria survive in limited environments. Gene chip shows that (p) ppGpp is a global transcription‐regulator of genes related to important bacterial metabolic processes.
Jun, Wu, Jianping, Xie
openaire +2 more sources