Results 11 to 20 of about 14,528 (201)
(p)ppGpp Metabolism and Antimicrobial Resistance in Bacterial Pathogens [PDF]
Frontiers in Microbiology, 2020 Single cell microorganisms including pathogens relentlessly face myriads of physicochemical stresses in their living environment. In order to survive and multiply under such unfavorable conditions, microbes have evolved with complex genetic networks ...
Bhabatosh Das, Rupak K. Bhadra
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Co-crystalization reveals the interaction between AtYchF1 and ppGpp
Frontiers in Molecular Biosciences, 2022 AtYchF1 is an unconventional G-protein in Arabidopsis thaliana that exhibits relaxed nucleotide-binding specificity. The bindings between AtYchF1 and biomolecules including GTP, ATP, and 26S rRNA have been reported.
Ming-Yan Cheung +4 more
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ppGpp signaling plays a critical role in virulence of Acinetobacter baumannii
Virulence, 2021 Acinetobacter baumannii, a major nosocomial pathogen, survives in diverse hospital environments, and its multidrug resistance is a major concern. The ppGpp-dependent stringent response mediates the reprogramming of genes with diverse functions in several
Kyeongmin Kim +8 more
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Antibiotic Persister Cells in Acinetobacter baumannii: Overview of Molecular Mechanisms and Removal Strategies. [PDF]
Environ MicrobiolAntibiotic persister cells in Acinetobacter baumannii: review of the molecular mechanisms involved in this physiology, such as toxin/antitoxin, second messengers, SOS response, PAA or membranes; and elimination strategies such as antibiotics or phages.
Vergoz D +3 more
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(p)ppGpp: Still Magical? [PDF]
Annual Review of Microbiology, 2008 The fundamental details of how nutritional stress leads to elevating (p)ppGpp are questionable. By common usage, the meaning of the stringent response has evolved from the specific response to (p)ppGpp provoked by amino acid starvation to all responses caused by elevating (p)ppGpp by any means.
Katarzyna, Potrykus, Michael, Cashel
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SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome. [PDF]
, 2020 Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), together named (p)ppGpp, regulate diverse aspects of Salmonella pathogenesis, including synthesis of nutrients, resistance to inflammatory mediators, and expression of secretion ...
Fitzsimmons, Liam F +8 more
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ppGpp Conjures Bacterial Virulence [PDF]
Microbiology and Molecular Biology Reviews, 2010 SUMMARYLike for all microbes, the goal of every pathogen is to survive and replicate. However, to overcome the formidable defenses of their hosts, pathogens are also endowed with traits commonly associated with virulence, such as surface attachment, cell or tissue invasion, and transmission.
Zachary D, Dalebroux +3 more
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ppGpp analogues as antibacterial compounds [PDF]
Nucleic Acids Symposium Series, 2008 Immediately after sensing the inception of amino acid starvation, bacteria respond pleiotropically with the stringent response via RelA, mainly resulting in the accumulation of the signal molecule (p)ppGpp. A series of analogues of ppGpp that inhibit RelA activity was prepared in order to control the ability of bacteria cells to react to the changes in
Wexselblatt, Ezequiel +3 more
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ppGpp is a bacterial cell size regulator [PDF]
Current Biology, 2020 SummaryGrowth and division are central to cell size. Bacteria achieve size homeostasis by dividing when growth has added a constant size since birth, termed the “adder” principle, by unknown mechanisms [1–4]. Growth is well known to be regulated by ppGpp, which controls anything from ribosome production to metabolic enzyme activity and replication ...
Ferhat Büke +4 more
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Microbiology Spectrum, 2023 ppGpp is a ubiquitous small nucleotide messenger that mediates cellular self-protective responses under environmental stress. However, the mechanisms of ppGpp that control transcription and other metabolic processes depend on the species, and ppGpp ...
Yang Song +4 more
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